@preventionalist

Preventive Cardiologist based Southlake, TX

[Sek Kathiresan MD @skathire]

Verve's 2nd swing at PCSK9 editing yields clean safety profile, teeing up Lilly opt-in decision https://t.co/reqi3rjAR2

[Prof Kausik Ray FMedSci @ProfKausikRay]

Since 2016 and the Improve It trial we have known that two drugs statins and ezetimibe combination therapy were better than statin monotherapy after an MI for CVD prevention. We also have had PCSK9i trials showing other combination therapies also reduce CVD when added to statins.

[Ahmed Bennis MD 🫀 @drbennisahmed]

Efficacy and safety of angiotensin receptor–neprilysin inhibition in HF patients with ESKD on maintenance dialysis

improving left ventricular function, reversing left ventricular remodelling, and reducing the risk of all-cause mortality

https://t.co/cNzyIg54zl

[Khurram Nasir @khurramn1]

Easy to show added value on top of redundant risk tool (risk scores)

Smartly these trials not comparing Vs CAC, as very unlikely to add on a simple surrogate of athero burden and especially when cac zero

Despite this great tool at look at plaque changes

[JAMA Cardiology @JAMACardio]

Most viewed from @JAMACardio:

Measurement of coronary artery calcium (CAC) score among adults without ASCVD and of intermediate risk, as well as borderline risk in certain cases, can help refine risk stratification when a clinical decision is uncertain.

https://t.co/FdWsH2M1iN

[Gregg Fonarow MD @gcfmd]

The available evidence suggests that intensification of loop diuretic agents produces relief of physical signs of decongestion, but the importance of different strategies for short-term decongestion strategy for health status and long-term outcomes has not been established

[Ahmed Bennis MD 🫀 @drbennisahmed]

Outcomes of Reinitiating Direct Oral Anticoagulants After Intracranial Hemorrhage: A Sequential Target Trial Emulation Study

DOAC is associated with lower risk of all-cause mortality. The optimal timing of DOAC reinitiation varies by ICH severity

https://t.co/JXMhbUh08e

[Hilly Paige Jr @hillypaige2]

👀Over 9000 test kits already distributed - Order your test kit today!
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@MendedHearts @WomenHeartOrg @MensHlthNetwork @NatForumHDSP @HealthyWomen @advcardiohealth @Amgen @HeartNurses @ABCardio1 @BHMinfo

[@preventionalist @preventionalist]

@hillypaige2 @khurramn1 @RonBlankstein CAC is to disease detection as Mammogram is to breast cancer. It detects disease, but is the start of the process, not the end. CCTA with AI quantitative plaque analysis is analogous to the biopsy for breast cancer. As I learned as a medical student, “No meat, no treat”!

[JACC Journals @JACCJournals]

Higher density, lower risk #cvCAD plaque? Higher #CAC density confers a lower risk of future #CVD events with a ~20% lower risk for each standard deviation increase in density in this systemic review and meta-analysis https://t.co/kkMCjQdq1c

#YesCCT #JACCIMG @DrAndrewLin

[Matthew Budoff MD @BudoffMd]

An important article demonstrating utility of CAC to improve outcomes in JAMA today

doi:10.1001/jama.2025.0584

with great editorials by @RonBlankstein and @MichaelJBlaha

[Dr. John A Rumberger, PhD, MD, FACC, MSCCT @DrRumberger]

Thank you so very much

[Thomas Dayspring @Drlipid]

@DrRumberger Here is the data with LDL-C - same would be true of apoB

[Khurram Nasir @khurramn1]

To add context

Usually greater distribution reflects higher burden as u can see significant attenuation of risk in fully adjusted models

Also in case of mismatch, CHD risk higher with burden vs distribution

@DrRumberger @MichaelJBlaha @RonBlankstein

[Hilly Paige Jr @hillypaige2]

#LpaAwarenessMonth
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@endless_health @Amgen

[The Heart @ZHeart11768530]

🔴The Year in Cardiovascular Medicine 2024: the top 10 papers in dyslipidaemias⤵️ #2025Viewpoint #openaccess @ESC_Journals

🔹https://t.co/wdZTfB4YfB
#FOAMed #MedEd #medstudent #paramedic #Cardiology #CardioEd #medtwitter #meded #CardioTwitter #cardiotwiteros #MedX

[Ash Paul @pash22]

Alternative LDL Cholesterol–Lowering Strategy vs High-Intensity Statins in Atherosclerotic Cardiovascular Disease: A Systematic Review and Individual Patient Data Meta-Analysis
https://t.co/QzmuO4wgfT @SABOURETCardio @gbiondizoccai @Coronary4front @cpgale3

[Sergio Kaiser MD, PhD, FACC, FESC 🇧🇷🇮🇱🇷🇴🇺🇦 @pabeda1]

As a heavy morning coffee drinker, I felt such a sense of well-being (enhanced by the coffee, supposedly) after reading this editorial by @TomLuscher...
https://t.co/2w95kNmCxE 👇🏽👇🏽
@SABOURETCardio @AmarPut @drpatrickholmes @DrRajivsankar @biljana_parapid #CardioTwitter

[JAMA Cardiology @JAMACardio]

High-intensity statins lower LDL cholesterol in high-risk ASCVD patients, but combining moderate-intensity statins with ezetimibe offers similar benefits with a lower risk of new-onset diabetes and statin intolerance. https://t.co/p0OrAKjTEC @CardioSSoon

[Enochåtti @Klartsomspad]

@Drlipid @garytaubes Gary Taubes is very far from evidence based. Please reconsider. One example: https://t.co/OGsAOgV0G5