Raya Shu | RNA nerd

RNA | ribosome | brain | data | mountain | ocean | around the world

[Shaun Maguire @shaunmmaguire]

POV @SpaceX catching a rocket

[Cell @CellCellPress]

In the latest issue! Exploring RNA-guided DNA scissors in eukaryotes: Are Fanzors counterparts of CRISPR-Cas12s? https://t.co/VY1ZrRaJcK

[Daphna Rothschild @D_Rothschild_]

My postdoctoral work is finally out! Please consider retweeting.

I am very proud of this project. I want to thank my wonderful advisors @mbarnalab and @jkpritch and collaborators Theo Susanto, @xsui98, @WangXiaoLab, @spence_jeffrey_, and many others for a major team effort!

[Science Magazine @ScienceMagazine]

An mRNA #adjuvant that encodes #IL12 amplifies and prolongs immunity from the Pfizer #COVID19 vaccine in aged mice, and features a multiorgan protection sequence that restricts expression to targeted tissues. @ScienceTM https://t.co/0dUyXUvkMs

[Oded Rechavi @OdedRechavi]

It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇
https://t.co/I2j2pAel69

[julie aspden @RNA_julie]

Delighted to share our new pre-print on translational activity of 80S monosomes. @AlbertBlandy @EltonVasconcel8 @AmyTurn67763683 @LabFontana @MichaelaAgapiou Thanks to @BBSRC and @wellcometrust. Great for this work to benefit from @RiboCode team input https://t.co/3soqDSHwHT

[Ming "Tommy" Tang @tangming2005]

R can not handle big data? R Dplyr vs. DuckDB - How to Enhance Your Data Processing Pipelines with R DuckDB https://t.co/Kj39J06mx2 #rstats

[Demis Hassabis @demishassabis]

Thrilled to announce AlphaFold 3 which can predict the structures and interactions of nearly all of life’s molecules with state-of-the-art accuracy including proteins, DNA and RNA. Biology is a complex dynamical system so modeling interactions is crucial https://t.co/Gs4GoOB3fD

[Eric Topol @EricTopol]

Our most complex biologic system—immunity—is reviewed in 3 new @CellCellPress papers, open-access
Adaptive
https://t.co/rJRBnV7u8I
Innate
https://t.co/PMKA6KgL7R
New insights
https://t.co/rJRBnV7u8I @RMedzhitov

[Cell Press @CellPressNews]

Two research teams successfully regenerate brain neural pathways #inmice using stem cells from rats. 🐀 🧵

@cellcellpress @leo_jwu @kkbaldwin238

[Michael Fischbach @mfgrp]

How to pick a problem. Today in @CellCellPress. 1/53
https://t.co/Id4YaXWuup

[Trends in Pharmacological Sciences @TrendsinPharma]

The April 2024 issue of Cell Press Trends in Pharmacological Sciences is online now.

https://t.co/RxYykutz7H

On the cover: Translational adaptation in breast cancer metastasis

@a_navickas @Institut_Curie @schen_sc @genophoria @Ucsf_Biochem @UCSF

[Molecular Cell @MolecularCell]

Online Now: Time-resolved profiling of RNA binding proteins throughout the mRNA life cycle https://t.co/qWqQPVNslR

[Ming "Tommy" Tang @tangming2005]

Towards self-regeneration: exploring the limits of protein synthesis in the PURE cell-free transcription -translation system https://t.co/cX3GPi5rlp

[Oded Rechavi @OdedRechavi]

Is forgetting a bug or a feature? Can you delay it and remember longer? Our 🥶COOLEST paper to date (and our most poetic abstract…) Show LOVE ❤️and please SHARE! Thread (1/N)👇
https://t.co/nhe4P2dk7G

[Alexander Karollus @AlexKarollus]

Cracking the regulatory code: We have genomes for 1000s of species, but ENCODE only for 2 – what do we do? Natural language models have shown that syntax and semantics can be learned from text alone. Can we do the same for genomes?⬇️
https://t.co/MIFqNVfAlC

[Manolis Kellis @manoliskellis]

Excited and proud to share our #SingleCell dissection of #ALS and #FTLD out in #Cell this week, across 620,000 cells, 44 cell types, 73 donors, and two brain regions.
Although ALS affects #movement vs. FTLD #cognition, the two are nearly identical in the cell types, genes, and pathways they affect, both in #familial (monogenic) and in #sporadic (polygenic) cases, providing hope and candidate targets for common #therapeutic programs, implicating #LongRange-projecting neurons, and #cilia genes and pathways, necessary for their growth, but also #vascular changes and blood-brain-barrier function and integrity.
News: https://t.co/P8h8xM8qdM
Paper: https://t.co/c44unfZfkW
Preprint: https://t.co/phVZ9umRyx
Data: https://t.co/lBLG1wJ46Y
#NeuroDegeneration #ADRD #Alzheimers #FTD #FrontoTemporalDementia #LouGehrigsDisease #MyriamHeiman #SebastianPineda #VeroniqueBelzil #LiveLikeLou @iamalsorg @bsw5020 @alsadvocacy @ProjectALSorg #MotorCortex #BetzCells #VENs #C9orf72 #TDP43 #NeuroDegen #MCx @MTPA_US @NIH @NIHAging @GerstnerFdn @PackardFdn

[David R. Liu @davidrliu]

An exciting new report in @NatureBiotech from @WangXiaoLab’s team led by @HongyuChenChem shows that mRNAs with branched poly-A tails yield much higher levels, and prolonged production, of the corresponding proteins compared with conventional single-tailed mRNA. This discovery could enhance macromolecular therapeutics and stimulate additional tail-engineering approaches to modulate the potency and durability of proteins made from mRNA.

[Kenny Workman @kenbwork]

ML models like Evo + AlphaFold are emerging to engineer molecules.

It is sometimes unclear how to use these tools to build drugs.

We trace a realistic design, build and test loop of virus capsids on LatchBio.

[Patrick Hsu @pdhsu]

Is DNA all you need?

In new work, we report Evo, a genomic foundation model that learns across the fundamental languages of biology: DNA, RNA, and proteins. Evo is capable of both prediction tasks and generative design, from molecular to whole genome scale.