Rohan

🦠 Patient Zero @LongCovidLabs

[Rohan @rd108]

Can we coordinate our way to a cure for Long COVID? 🧵

[Danielle Beckman @DaniBeckman]

People who tested positive for #COVID have a higher risk of being diagnosed with other infections in the following months. This has been shown for years and hundreds of publications in the topic. Covid has an impact on the immune system we still don't fully understand.

[Rohan @rd108]

@timourxyz @syntonikka looks amazing 🙌

[Rohan @rd108]

@Yash25571056 Do you think this is the underlying cause of chronic fatigue in Long COVID?

[Rohan @rd108]

If anyone is working with large datasets that might be relevant here, please reach out to @longcovidlabs - we'd love to help support this research.

[Rohan @rd108]

Again and again we see viruses linked to dementia and neurodegenerative disorders. This new study (n>160,000) showed high dose flu vaccines reduces Alzheimer's dementia.

[Eric Topol @EricTopol]

We've seen the Shingles vaccine is linked with reduced risk of Alzheimer's and dementias in 4 large natural experiments.
Today, the potential of high-dose flu vaccines vs standard dose for the same in a large retrospective age 65+ cohort [N>160,000). More pronounced in women (like Shingles vaccine)
https://t.co/dxYzURf7QH

[Rohan @rd108]

What about dementia, specifically? We may need to wait for researchers with access to large epidemiological datasets to find out.

[Simon Spichak @SpichakSimon]

Lots of clinical trials for Long COVID coming out. Here's a quick guide on how to assess it.

A study is getting quite a bit of coverage, suggesting that the antidepressant fluvaxamine is effective for Long COVID. We'll use it as an example.

https://t.co/p5WBSCkmqp

[Rohan @rd108]

@PhotonTurtle If viral persistence is root cause, I imagine this like other vagus interventions are just treating symptoms. Hope you're hanging in there.

[Rohan @rd108]

Fascinating. May explain the micro-dosing GLP-1 protocols for Long COVID - we know there is significant dysautonomia and vagus nerve dysfunction.

[Prof. Kevin J. Tracey, MD @KevinJTraceyMD]

Ozempic and GLP-1 cause weight loss via the vagus nerve. In people whose vagus nerve was surgically cut (below the diaphragm, not in the neck), GLP-1 did not reduce food intake or accelerate metabolism. These drugs work through the vagus, in ways we still do not fully understand.

[Rohan @rd108]

@sama @tyler_m_john Complete non-answer. Pathetic @sama. Here's the real answer: "I will do almost anything for money. I do not believe the consequences of my actions will have negative impact on me."

[Rohan @rd108]

One of those "hand-washing reduces infections" paradigm shifts - the role of viruses in accelerating aging is still not fully acknowledged.

I predict COVID-19 will, unfortunately, be a prime catalyst for this.

[David Sinclair @davidasinclair]

During their lives, centenarians rarely get sick. New paper with 1,400 subjects finds a history of infections (pneumonia, herpes, UTIs) associates with earlier frailty. The authors speculate that obesity makes people more susceptible & that viral infections may accelerate aging

[Rohan @rd108]

@imyouralfred tell @mattmedved to call me. he never calls. then cd ~/ && rm -rf . (just kidding, don't do that)

[Jon Douglas @atranscendedman]

National Taiwan University researchers analyzed data from over 97 million individuals and found that COVID-19 is linked to a 49% higher risk of developing autoimmune diseases.

The risk rose after severe infection but dropped by 44% in vaccinated people.

https://t.co/cKhpGXuK0Z

[RTHM @RTHM_Health]

A new RECOVER study of 6.4M health records shows Long COVID risk has not decreased from 2020–2024. Incidence stayed stable across variants, reinforcing Long COVID as an ongoing public health priority.
Read the study: https://t.co/RN66kGhyxM

[Rohan @rd108]

@x3r0gx4 Yes, although my PEM was less severe than others

[Rohan @rd108]

3 years after antivirals and monoclonal antibodies cured my long COVID symptoms. Science can feel painfully slow. But hats off to the scientists, doctors and companies pushing the rock up the hill.

We need a global Moonshot for Long COVID, now.

[plague ralph 🐀 (capo) @x3r0gx4]

New cases series: @Invivyd's Pemgarda (Pemivibart) monoclonal antibodies shown to reduce PEM in three heterogenous Long COVID cases

Is this the first evidence published in a scientific journal of COVID-specific mAbs treating PEM in Long COVID?