Zhilin Li

Focused on understanding how blood and lymphatic endothelial cells may play a role in neuroinflammatory and neurodegenerative diseases. Opinions are my own.

[Immunity @ImmunityCP]

Online now: CTLA-4 blockade induces CD4+ T cell IFNγ-driven microglial phagocytosis and anti-tumor function in glioblastoma https://t.co/19tTYKXpCV

[John Lukens @LukensJohnR]

IFNγ drives neuroinflammation and demyelination in a mouse model of multiple system atrophy https://t.co/UD80i2DCqp

[John Lukens @LukensJohnR]

A novel immune modulator IM33 mediates a glia-gut-neuronal axis that controls lifespan: Neuron
Congrats to Iverchao @Iverchao1 and the Kipnis lab @kipnislab on the 'fly'🪰 work. Fly (adj). slang fashionable, stylish, attractive, etc.
https://t.co/28d77GuIy5

[Jonathan Kipnis 🟦 @jonykipnis]

A beautiful story demonstrating the importance of skull bone marrow in mouse and human disease. Congrats @erturklab’s lab! 👏

https://t.co/tYIhKT1wiN

[Waggoner Lab @LabWaggoner]

@ImmunityCP LN co-drainage between the pancreas, gut, and liver leads to immune crosstalk, impacting pancreatic autoimmunity @galaxy_brain18 & Hailey Brown & EsterházyLab
https://t.co/23J9ssXGTz

[Katerina Akassoglou @AkassoglouLab]

A Research Highlight “Activators of neurotoxic microglia in neurodegeneration: is the answer in blood?” by Caitlin Finney, David Brown @Sydney_Uni thoughtfully discussing our recent paper by @andrewmendiola et al @NatImmunol

https://t.co/mbNjp5l7a7

https://t.co/exaVN60o14

[John Lukens @LukensJohnR]

cGAS–STING drives ageing-related inflammation and neurodegeneration. Great paper @Nature
https://t.co/prpAkNGfTu

[John Lukens @LukensJohnR]

Traumatic brain injury induces an adaptive immune response in the meningeal transcriptome that is amplified by aging
https://t.co/CD6xZvFykr

[Ming "Tommy" Tang @tangming2005]

That's a wrap. If you like this content, follow me
@tangming2005

sign up for my newsletter https://t.co/aYaLVUjyym
subscribe to my chatomics youtube channel https://t.co/sHenXy41DL

[Ming "Tommy" Tang @tangming2005]

BioAlpha - hundreds to thousands times faster than Seurat/scanpy. Now you can run the full single cell pipeline for million cell dataset - under a minute. ⁦@ksonpham⁩ ⁦@bioturing⁩ https://t.co/OQ4dus6DKz

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Spatial mapping of cellular senescence: emerging challenges and opportunities | Nature Aging https://t.co/BmhylbP0F6

[Weizmann Institute @WeizmannScience]

More than 2.5 million people worldwide have multiple sclerosis; around 85% of them are diagnosed with the relapsing-remitting form of the disease. (1/6)

[Bo Wang @BoWang87]

🎉Exciting Update of scGPT 🎉: After receiving significant attention from the community since our April release, we're thrilled to announce the first major update for scGPT - a foundation model for single-cell multi-omic data.

This update integrates community feedback and leverages the latest data release from @cellxgene. It boasts larger pretraining data, and more robust models, and expands the range of application tasks.

Pre-print (V2) available: https://t.co/4aB2c4ZgJy
Access our open-source code and models here: https://t.co/13n0bJvgT2
Detailed tutorials: https://t.co/enNqXqXkdY

Highlights of this update include:

🔬 Introducing the first GPT-style foundation model for single-cell multi-omic data, pretrained on over 33M human cell atlas data.

💡 Our generalist approach enables one model to accomplish multiple tasks in single-cell analysis, including multi-omic integrative analysis and perturbation prediction.

🧬 Discovering gene-gene interactions specific to various conditions using learned attention weights and gene embeddings.

🚀 Uncovered a scaling law showcasing continuous model performance enhancement as data volume increases.

🐾 scGPT model zoo (see github) now offers multiple pre-trained foundation models for various solid organs and a comprehensive pan-cancer model. Begin exploring your data with the most fitting foundation model.

We welcome your thoughts on specialist vs generalist approaches in single-cell studies. Many thanks for the following technical analyses of scGPT:
1. Excellent twittorial by @simocristea: https://t.co/ICq3V78oxG
2. Comprehensive review on LLM in cell biology by @s_batzoglou: https://t.co/xtl5WCXijC
3. Insightful blog by @SalvatoreRaieli: https://t.co/7v8PRv9NNc

Kudos to Haotian (@HAOTIANCUI1) & Chloe (@chloexwang1) for their exemplary work on this project. @VectorInst @pmcc_ai @UHNAIHUB @bradwouters @drbarryrubin @UofT_TCAIREM @UofT_LMP @UofTCompSci @uoftmedicine

[Nature Cardiovascular Research @NatureCVR]

@GordonConf #atherosclerosis day 4- enjoying the science and stimulating conversations with attendees. Several talks presented works from our new Collection on the subject. Please check it out https://t.co/szmJNCapN3

#CardioTwitter #vasculardisease #hyperlipidemia

[Xiaowu Gu @XiaowuGu]

An excellent review (and nice title 😎) on reelin and its many functions throughout the body from Joachim Herz and colleagues at @UTSWGradSchool

https://t.co/9rNcjVrZhe

[Anu Suomalainen Wartiovaara @AWartiovaara]

My research group has 10 nationalities, professionals from 4 continents. Many used Ggl-translator to read the new gov’nt strategy. The rule of 3 mo unemployment inducing exit from the country would have made them to go elsewhere. The professionals can choose. @PetteriOrpo

[Zhilin Li @riselin]

The new Finnish government is proposing detrimental changes to the future of the country. Please sign the petition Against the Proposed Extension of Residency Requirements for Permanent Residence and Ci - Sign the Petition! https://t.co/4v4L2ZTiwo via @Change

[Denis Wirtz @deniswirtz]

Download our updated database of POSTDOC fellowships in NEUROSCIENCE/NEUROLOGY.

We list 27 fellowships. For each entry, we provide a description, a link, $ amount, eligibility, and deadline.

Download is here: https://t.co/EbTahdzJ9X

[John Lukens @LukensJohnR]

Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease.

Congrats to @OlegButovsky and lab on the exciting work.
https://t.co/4m43hOIspB

[Ming "Tommy" Tang @tangming2005]

mRNA-based cancer therapeutics https://t.co/J8rgy0uUM8