Andréa Rocha

Postdoc Researcher @salkinstitute. Metabolism │ Immunology │ Non-coding RNA │ Microprotein - 🇧🇷

[Andréa Rocha @rochaandreal]

Did you know that some upstream ORFs can actually encode functional microproteins? We recently discovered that the SLC35A4 upstream ORF produces a 103aa single-pass transmembrane microprotein that influences mitochondrial activity @salkinstitute https://t.co/B1axoJuck7

[Ming Li Lab@Umich @MingLi_Umich]

New paper from the lab, lead by graduate student Liang Chen. Here, guided by genome-wide CRISPR screening, we demonstrated that either lipids have a big impact on the lysosomal function, especially under the storage disease conditions. https://t.co/5emVVLZSuq

[Daniel J Drucker @DanielJDrucker]

Studies of sperm mitochondrial activity in mice #obesity reveal that microRNA let-7 in sperm reprograms offspring metabolism by modulating mitochondrial function during early development
https://t.co/oxK3bpkYYc

[Jonathan Weissman's Lab @JswLab]

Incredibly exciting and important work from @thenormanlab scaling CRISPR screens!

[Andréa Rocha @rochaandreal]

Excited to see our work featured in the Salk news release! https://t.co/GyeOAMmGwz

[Andréa Rocha @rochaandreal]

This work highlights how many ‘hidden’ microproteins remain to be discovered. uORFs aren’t just passive elements — they can encode regulators of metabolism and beyond. Excited to see where this field goes!!

[Andréa Rocha @rochaandreal]

Thrilled to share that our paper is finally out in @ScienceAdvances !!!
We uncovered how a uORF-encoded microprotein can control mitochondrial biology and lipid metabolism in brown fat. So proud of this work! https://t.co/KsGKLucLpe

[Andréa Rocha @rochaandreal]

This work builds on our 2024 paper where we first described SLC35A4-MP. Here, we extend the story and uncover how this microprotein shapes mitochondrial biology and lipid metabolism in vivo.

[Lukas Valihrach @LukasValihrach]

Single cell lipid biology https://t.co/IlRaYW9a52

[Trends Cell Biology @TrendsCellBio]

Regulation of lipid droplet dynamics and lipid homeostasis by hydroxysteroid dehydrogenase proteins https://t.co/N4pJdaEhFw

[The Colonna Lab @TheColonnaLab]

Our new paper in Cell Host & Microbe:
Low-fiber diets worsen C. difficile infection by increasing epithelial MHC-II and expanding pathogenic CD4+ IELs. Fiber-derived acetate and FFAR2 boost ILC3 IL-22, suppressing colonic MHC-II and aiding recovery.
https://t.co/YRBA7anvOa

[Shareen Forbes @ShareenForbes]

Macrophages are safe and associated with improved clinical outcomes in liver cirrhosis. Very encouraging for our joint preclinical study using macrophages in islet transplant @BreakthroughT1D @SNBTS_TCAT @EdinburghUni Well done to all the team @brennap9 @EdinUni_IRR @SNBTS_TCAT

[Cell Press @CellPressNews]

In this recent @MolecularCell article, @em_maragkakis & colleagues report that "Senescence suppresses the integrated stress response and activates a stress-remodeled secretory phenotype" #CellBio2024 https://t.co/OjHtmxduYh

[Matthias Mann Lab @labs_mann]

China clearly sees the potential of proteomics and is about to place a gigantic bet on it; multi-billion dollar and 30 years!!! All the better for the advancement of science and health. We contributed to the white paper out now in @Nature
https://t.co/480tmOJQ3C

[Nature Aging @NatureAging]

Online now!✨RESEARCH: Vattathil, Gerasimov et al map genetic variants that regulate miRNA expression in the aged human brain, and identify miRNAs linked to psychiatric and neurodegenerative disorders @wingolab https://t.co/kPnMo4Zr3l https://t.co/lEYjOuK31F

[Bruno Ramos-Molina, PhD @Brunorm84]

Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer @nature https://t.co/s5HxxkdSM2

[Andréa Rocha @rochaandreal]

A new publication by @DeSiqueiraMK focuses on adipose progenitors and translation pathways. Congratulations! 👏

[Mirian Krystel De Siqueira @DeSiqueiraMK]

Excited to share our latest work in @CellReports highlighting a PPARγ-dependent remodeling of translation machinery in adipose progenitors.
Amazing collab between our lab @ClaudioVillanu @YangLabUCLA and @LauraHulea
@CellPressNews @uclaibp https://t.co/y7D3uUjD6t

[Mirian Krystel De Siqueira @DeSiqueiraMK]

Excited to share our latest work in @CellReports highlighting a PPARγ-dependent remodeling of translation machinery in adipose progenitors.
Amazing collab between our lab @ClaudioVillanu @YangLabUCLA and @LauraHulea
@CellPressNews @uclaibp https://t.co/y7D3uUjD6t

[Camilla Schytz @CSchytz]

New preprint, the first after my my PhD.

Link to article: https://t.co/EVm0uXiWWx

We investigate how high-altitude exposure affects mitochondrial subcellular distribution, ultrastructure, respiratory control, and intrinsic mitochondrial respiratory capacity.

1/6

[The Colonna Lab @TheColonnaLab]

Our work by Fachi et al. @zefachi is out in PNAS! We show how NKp46+ ILC3s boost early gut defense against C. difficile infection by producing GM-CSF to support neutrophils. A potential path to new CDI treatments!
https://t.co/eGErtKTImU

[Krishna Shrinivas @shrinivaslab]

Excited for 1st paper from our lab - led by the amazing @RyanKrue in collab. with @BrennerGroup1.

How do we design intrinsically disordered proteins (IDPs) that lack a stable structure and are continuously shapeshifting for different target functions?

https://t.co/OjIpmOGyZ1