Humbling 30 year Biotech stats shared by @verdadcap in a recent report:
Just over 1,000 biotechs hit $200M mkt cap at some point. Of those, 67% have lost value (had cumulative negative returns), vs 48% for all other US companies.
Of these 600+ biotechs, roughly 50% were acquired at negative total returns, 10% delisted, the remaining 40% are still public and underwater for their average investor
The median biotech company in this period has delivered an annualized return of -15% (vs 1% for other US Companies).
It's a tough business.
@SawyerMerritt@elonmusk@Tesla_AI Switzerland is Tesla’s chance to shine and show Europe the way! OG FSD buyers should get ability to transfer to new car.
Vaccines do not cause autism. You’ve almost certainly read that before — but often without a full explanation of how we know it to be true. Here's how we know. https://t.co/X1WTIx4Ndn
How to look at our impact on life on earth in 3 graphs:
1) Humans are just 0.01% of all biomass. (The graph is gorgeous!)
2) Humans + domesticated animals have almost completely displaced wild mammals.
3) We use 45% of habitable land for agriculture.
BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
Die internationale Krebsforschungsagentur@IARCWHO hat den Süßstoff #Aspartam heute als "möglicherweise krebserregend" eingestuft.
https://t.co/ZjUYqvGMgG
Warum das trotzdem KEIN Grund zur Sorge ist: ...
This is an amazing table of the cost overruns of mega projects
Nuclear storage has a mean cost overrun of 238%, while with nuclear power its 120%
Solar power has a mean cost overrun of 1%
https://t.co/1zsdkTWfgZ
The benefit of bivalent boosters for enhanced, ~80% protection from hospitalizations and deaths (vs vaccine plus prior prior booster or unvaccinated) has now been shown in 6 countries (Israel, US, Denmark, Norway, Finland, Sweden)
Weil das immer wieder gefragt/diskutiert wird, hier mal ein aktueller Vergleich der Fahrzeugbrände von Verbrennern und BEV, bezogen auf die gefahrenen Kilometer. Zahlen von 2020 in USA.
The Covid bivalent vaccine booster works better than expected.
I've reviewed the cumulative data
https://t.co/tR5S4BBaYb
That's in contrast to a @NEJM essay today and 2 lab studies that used a pseudovirus assay without assessing the XBB variants
We have open positions in my brand new lab at the @karolinskainst https://t.co/iyjMGe59ih to study and engineer gene regulation in the context of regeneration using these technologies. If this sounds interesting and want to discuss PhD and Postdoc opportunities please reach out!
Thrilled that our Spatial ATAC manuscript is now out @NatureBiotech
Open: https://t.co/DedMIjUl9z
We repurposed the #Visium platform @10XGenomics to capture and profile open chromatin with spatial resolution in tissue sections from mouse and human.
'Disruptive' science has plummeted — and no one knows why.
Research in the 2000s is much more likely to incrementally push science forward than to veer off in a new direction.
Check out my latest for @Nature with @russellfunk, @dashunwang, @yian_yin
https://t.co/Uh5hAHkrSw
Agouti gene (Asip) is the first obesity gene to be discovered in 1992 in agouti mice--a fat yellow mice with a mutation that reprograms a skin specific protein to express throughout the body. However, no mutations in this gene has been reported in humans since 1992. 🧵