REVIEW
Liron Bar-Peled & Nora Kory (@HarvardChanSPH):
Metabolic compartmentalization (the spatial & temporal separation of pathways & components in a system) can shape organismal #metabolism, while its dysregulation can lead to pathological states.
https://t.co/MPRnxLpKIV
RESEARCH | From @danielcoral04, @paulwfranks (@DiabetesLUDC):
The authors characterize genetically determined discordance between #obesity & type 2 #diabetes, identifying discordant genes that may convey protection against type 2 diabetes in obesity.
https://t.co/ZvkkWr1ApA
Imagine you could stain whole adult mice with standard IgG antibodies. What you couldn't do! We present wildDISCO technology for this🤗, creating the first whole body vascular, lymphatic, and nerve atlases. By @HongchengM@jieluo692 https://t.co/c2F91KQPv4 🧵👇🏼(turn on the sound)
This is an interesting protocol for rapid fractionation of mitochondria from @Mito_Redox with some help from us @ASofiaHCosta
Rapid fractionation of mitochondria from mouse liver and heart reveals in vivo metabolite compartmentation https://t.co/y7IXQr06xT
Monitor autophagic flux in mammalian cells easily with our new method, now out in @eLife! Pulse-labeled HaloTag reporters are processed in lysosomes, releasing proteolysis-resistant labeled Halo. Free labeled Halo amount = autophagic flux! →western/in-gel fluo/microsc./flow cyto
Glad to share a new paper describing an exercise-induced molecule that inhibits feeding. Fortunate to be onboard with @longlabstanford for this amazing discovery! https://t.co/Cuu4SrmQ11
Current events are profoundly disturbing, and it hardly is time to focus on anything else. Science has always been one great unifier and, in that spirit, we hope you can join us for a MITOtalk we look forward to, this thursday, by the excellent @airdlab Katherine Aird.