@tomrenniesoccer 5’10” heads it in among the tall timbers of ENG who were out of position and lacking guts and driven by fear and lack of individual responsibility for their space in the TEAM shape. YES coach low blocked too soon. The players were poor in the dictator’s shape. Total team drop off
@MiguelDelaney@tomrenniesoccer Too early in the back 5 for Eng. Argentina far better TEAM and …… Messi showed he is the best at StaTurgery …. Strategic Surgery!
@davidasinclair Agreed. But school is only one piece of a youngsters education. If the parents don't inspire curiosity and self-learning in life at a very early stage school might not be enough. And after becoming a teenager all of us need to take agency and start self-learning untill we die.
"The 4-month intervention with this MDF was effective in reducing IHTC in patients with NAFLD by an absolute reduction of −5.89% and a relative reduction of −24.30% after adjusting for weight loss. Such effect was partly mediated by altered composition and metabolic profile of gut microbiota."
Unlike most senolytics, which trigger cell death via SCAP pathways, these compounds induce ferroptosis, an iron-dependent form of cell death driven by lipid oxidation. The screen to find them looked like this:
NEW STUDY finds certain fatty acids selectively kill senescent "zombie" cells. The molecules exploit a fundamental biophysical weakness in senescent cells, a totally new approach. Could we simply consume these moleculs to treat aging? ...🧵
As a medical school professor, I taught that dementia was in many cases genetic and irreversible.
I was wrong.
A landmark JAMA study just followed 131,821 people for up to 43 YEARS and found:
☕ Caffeinated coffee: 18% lower dementia risk
🍵 Tea: 14% lower dementia risk
⚡ Total caffeine (top quartile): 22% lower risk
The sweet spot? 2-3 cups of coffee or 1-2 cups of tea daily (~300mg caffeine).
Here's what's critical: DECAF showed NO protection.
That means it's the caffeine -- not the antioxidants alone -- driving neuroprotection.
This held true regardless of APOE4 status, BMI, or smoking history.
The metabolic connection? Caffeine improves insulin sensitivity, reduces neuroinflammation, and blocks adenosine-driven neurodegeneration -- all pathways rooted in metabolic dysfunction.
This is exactly what I cover in Lies I Taught in Medical School -- the diseases we blamed on bad luck often trace back to metabolic root causes.
Full breakdown coming on the Health Longevity Secrets podcast.
Source: JAMA 2026;335(11):961-974
https://t.co/xWLSvEiwn6
#Dementia #CoffeeBenefits #MetabolicHealth #BrainHealth #Longevity