Shubham Kumar

PhD candidate, MunroLab @MRC_LMB @Cambridge_Uni | @SBSNISER Alumnus | Looking at Golgi in Fly Neurons.

[Christina Qi @christinaqi]

I’m about to give a lecture to the Columbia Math Dept, but honestly I just wanna ask THE STUDENTS how they feel about AI frontrunning their life’s work & each other. 😂 Here’s what happened in plain English:

2 groups of mathematicians made a lifetime breakthrough one of the most famous problems that had gone unsolved for almost 100 years.

But they only solved a much easier version of the problem w/lots of AI assistance, & then a false rumor went around that Anthropic had solved the problem because one of the authors was working at Anthropic lmao.

So then OpenAI decided to frontrun them & spend $20 million of compute to solve the problem. 😏

And since it’s a famous problem there’s a $1M prize for it like the Nobel.

Then the OpenAI dude told the group leader you can share the prize with us & we’ll even let you claim first authorship but you need to drop the name of your Anthropic coauthor from the paper.

Then the group leader got mad because that’s super unethical & felt like they secretly used his ChatGPT data to figure out what he was working on to frontrun him. At least that’s the Anthropic perspective.

The problem is so hard that the original two authors would’ve gotten a top math prize & generational prestige for just solving the easier version.

But OpenAI just brute forced it while seemingly stealing their idea and being unethical and everything.

If not for the drama the scientific achievement would’ve been comparable to curing a form of cancer in their field‼️

But instead no one’s questioning that it got solved, & instead it devolved into this shitshow. 😌

Now a lot of mathematicians are saying the hardest problems that they spend a lifetime working on are gonna get solved in a year or two. 🙃

And some mathematicians are now saying it’s like doping and they should ban using AI on some types of problems to “maintain the challenge.”

[Aniruddha Datta Roy @skinkomaniac]

Please RT: We're looking for PhD students @BioGeoSys! Do check out what we do and apply if you're interested in joining us!

[Simone Reber @SimoneReber]

FINALLY! This was challenging to publish but we believe it is an important discovery: https://t.co/lN4KQqfIC6

💫Thanks to the amazing team 💫 @bis_was_here @Omar136661 @KyoohyunK Carsten Hoege Benjamin Lorton @RainerNikolay @MatthewKraushar
@DShechter @GuckLab @VasilyZaburdaev

[Dibyendu Bhattacharyya @dibyenducellbio]

Intra-Golgi Golgin PpSgm1 and GRIP domain Golgin PpImh1 synergistically mediate Golgi cisternal stacking https://t.co/1UCL682Zoa

[Shubham Kumar @Shu6hamK]

Following the annual tradition, the student symposium of MRC LMB is happening on July 10th and 11th this year.

This year we are collaborating with Institut Pasteur!

Details 👇

[LMB-IP Graduate Life Sciences Symposium @LMBPhDSymposium]

This year's symposium will be co-organized with the world-renowned Institute Pasteur - a leading institution at the forefront of innovative biology research. Sign up to connect with some of the best minds in life sciences and learn from the experts! (1/2)

[Shekhar Gupta @ShekharGupta]

Probably the most insightful story you’ve read on the crisis..

Orders for Pahalgam satellite images from US firm peaked two months before attack

Soumya Pillai @soumya_pillai with #ThePrintExclusive

https://t.co/HEninbHyer

[Bureaucrats India @BureaucratsInd]

It is deeply regrettable to witness undignified and distasteful remarks directed at Foreign Secretary Shri Vikram Misri ~ a distinguished IFS officer who has served the nation with utmost dedication in critical diplomatic roles.

Bureaucrats India strongly condemns such unwarranted commentary.

@VikramMisri @MEAIndia @IfsAssociation

#OperationSindoor

[Reto Fiolka @RetoPaul]

Maybe the most amazing microscope paper of the year just dropped: Live 4pi-SIM (a.k.a I5S*):
https://t.co/RJale5ulmK

Having worked with Mats Gustafsson, I can attest that this is both extremely hard, but also extremely cool!

Kudos to the authors!

*https://t.co/ysoGgXIlF7

[Ishier Raote @ishier_raote]

Interesting preprint! ER-Golgi transport is transcriptionally regulated by Opi1-Ino2/Ino4 circuit, with YIP3, Sec16, Sar1 activity modulated in lipid stress.
ER sensing of lipid metabolism drives PRA family-dependent regulation of COPII vesicle transport https://t.co/FpRrbDSQIi

[JeanLab-UdeS @JeanlabUdes]

For the membrane trafficking crowd, we are thrilled to share our BioID map of RAB GTPases! It was a collective effort from many individuals initiated by Benoît, Raphaëlle, and Dominique and followed up extensively by Véronique! Many thanks to everyone!
https://t.co/I7av8x07Cg

[eLife - the journal @eLife]

Could there be an evolutionary benefit to ageing? https://t.co/QSiLvkR3yO

[EDRC2025 @edrc2025]

Welcome to the #EDRC2025 account of the 28th European Drosophila Conference which will take place in Alicante from the 25th to the 28th of September 2025! Stay tuned for the upcoming news!

[nature @Nature]

Much of the success of breakthroughs, such as AlphaFold, is thanks to a database of protein structures dreamed up in the 1960s by Helen Berman https://t.co/j7l4MJ5OeU

[Jake Smith @crying_EM]

After thousands of microscope hours and several years of painstaking optimisation, @glynnca93 and I are very excited to share our latest manuscript. We outline our approach to investigate the molecular organisation within hippocampus tissue using cryo-ET.

[Jane Austen @austendaily]

I certainly have not the talent which some people possess of conversing easily with those I have never seen before.

[nature @Nature]

Largest brain map ever reveals fruit fly’s neurons in exquisite detail https://t.co/3oavJhKV2Z

[Martin Pacesa @MartinPacesa]

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. @befcorreia @sokrypton

https://t.co/IPhMFpRgHh

[Florian Schueder @FSchueder]

Please check out our (@PDClab @bewersdorflab) latest work on determining the location of the lipid transfer protein VPS13B within the Golgi complex. We use 7-color #FLASHPAINT imaging to locate VPS13B within the Golgi complex. @JCellBiol @YaleMed

https://t.co/PFpyukNBl3

[Vipin M. Vashishtha @vipintukur]

So, in the end, let’s go back to the original query, “Is fever good or bad?

The short answer is: A little bit of fever is good, but a lot of fever is bad. We already knew that, but now we have a mechanism for why it's bad. 17/17

https://t.co/vWeQiVcq41

[Pastor_Pareja Lab @PastorParejaLab]

OptoTrap for endogenous protein clustering in Drosophila. COOL!!
In vivo optogenetic manipulations of endogenous proteins reveal spatiotemporal roles of microtubule and kinesin in dendrite patterning | Science Advances https://t.co/696scptVnr