Sujay Krishna Maity

Metabolic study enthusiast, Student at MDL, Science is fun with a dancing mind!

[Mizushima Lab (UTokyo) @MizLabUT]

Our new paper is out in @ScienceMagazine! We developed mice with reversible control of autophagy, and showed that restoring this pathway after its suppression reverses neuronal abnormalities and brain dysfunction, demonstrating the resilience of neurons. https://t.co/kegmU08mcY

[nature @Nature]

Nature research paper: GLP-1R–GIPR–PPARα/γ/δ quintuple agonism corrects obesity and diabetes in mice

https://t.co/sDlqnWVm7q

[James Olzmann @OlzmannLab]

1/ Thrilled to share our new paper in @Nature: “CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.” From our lab together with @apsarruda, led by co–first authors @alymathiowetz and @EmilyMeymand. 🥳
https://t.co/LHO31rNaxi

[James Olzmann @OlzmannLab]

Excited to share our new study out in @NatureCellBio! Led by postdoc @MikeLangePhD, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis.
https://t.co/QBM8e07IlC

[Niko McCarty. @NikoMcCarty]

Mouse studies often fail to replicate in surprising ways. Let me enumerate some of the ways:

1. Mice handled by male scientists feel less pain. The finding holds true when a female scientist does the experiment but holds a t-shirt, previously worn by a man, near the mouse. The effect fades after 30 minutes.

2. Mice spend less time licking an irritated part of their body when a human is nearby, “even if that ‘person’ is a cardboard cutout of Paris Hilton.”

3. Mice raised at five different animal facilities in Europe, under otherwise identical conditions, had “persistent differences in body weight” and behavior.

4. If two different scientists at the same university carry out the same experiment on mice, their results will be MORE replicable than if the same exact experiment were carried out by the same person at separate universities.

5. Mice that give birth in cages with little toys or knick-knacks produce more pups. Those pups are larger after 21 days.

6. “Mice housed on deep bedding had smaller adrenal, kidney, liver and heart weights as well as larger body and tail lengths compared with groups kept on shallow bedding” after just 12 weeks, according to one study.

7. Animals stored on higher shelves are more stressed and have impaired immune systems, probably because these areas are closer to lights and vibrate more. Mice on the top shelf of a rack receive 20-80x more light than mice housed at the bottom.

8. Mice exposed to even dim light during the night (e.g. an LED on a computer monitor) “had a body mass gain…about 50 percent more than other mice that lived in a standard light-dark cycle.”

9. After just four weeks, mice exposed to a dim light during the night ate more than those in complete darkness. (Mice, like humans, raid the proverbial refrigerator when they can’t sleep.) Many genes linked to inflammation were also activated.

10. Mice kept in cages with wood chip bedding eat about 1.5 grams of their mattress every day. This changes the bacteria in their microbiomes.

11. (Not about replication, but) about 80% of drugs are tested only on male mice. Even though some drugs, notably Ambien, are more potent in females and cause more side effects.

12. About 6% of all mouse genes are regulated in sex-specific ways. The expression level of more than 1,000 genes varies between males and females, and the level of another 600 genes wobble, up and down, during a female’s estrous cycle.

13. Grain-based food usually contains unknown amounts of phytoestrogens, which change the onset of an animal’s puberty.

14. The standard diet for mice, called AIN-93, hasn’t changed in 30 years. But manufacturing of that food HAS changed: Even if you use “the same grain-based diet used in the past by others, its composition will likely differ.” In other words, the same food used in mouse studies today vs. the 1990s is different, even if its name is unchanged.

15. Mice exposed to a regular, 37 Hertz magnetic field spend less time exploring open spaces, and more time sleeping.

16. Mice are kept in rooms between 69 and 79 degrees F. “But the natural comfortable temperature for mice is warmer — between 30 and 32 degrees Celsius (86 to 90 degrees Fahrenheit).” Colder mice experience more stress, their tumors grow faster than mice kept in warm rooms, and “mice genetically modified to develop obesity only gained a lot of weight at warmer temperatures but not at colder temperatures.”

All links at source below. These studies make for fun reading materials.

[Martin Picard @MitoPsychoBio]

Energy metabolism is really quite remarkable

Little bits of energy we call metabolites flow continuously, converging in our mitochondria (TCA or Krebs cycle) where they are re-routed and directed where needed

The basis of life and health is the flow of energy

Great animation showing the fate, trajectory, and possible routes that glucose (top) and glutamine (bottom right) take within most of our cells

Video by @janetiwasa

[Marcus Goncalves @MarcusDGon]

Macrophage degradation of bacteria provides carbon atoms and amino acids that are recycled into various metabolic pathways. Very cool finding https://t.co/tl87SbsQxg

[Sujay Krishna Maity @sujay_metabio]

I am elated to share that our recent work from the Metabolic Disease Laboratory got published in @DiabetesRC. Here, we identify #adipsin as a potential candidate for #plasmabiomarker for #aging, independent of its stereotypical roles in humans.
#diabetes
https://t.co/jklAWqslb6

[ESPN India @ESPNIndia]

A year of protest against the federation chief.
Slept on pavements for 40 days.
Was beaten, dragged by the police.
Nearly immersed all her medals in the Ganga.
Underwent knee surgery.
Sealed her Olympic spot after an unforgiving qualification process.
Became the 1st Indian woman wrestler to qualify for three successive Olympics.

And now, she's beaten the unbeatable defending champ, won two more bouts to become the first Indian woman to reach a wrestling Olympic final.

Words fail to appreciate what Vinesh Phogat has just done.

https://t.co/ItdNkkWO1w | #Paris2024

[Bruno Ramos-Molina, PhD @Brunorm84]

Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling @NatureComms https://t.co/vzJVE5IuZv

[Riekelt Houtkooper @rhhoutkooper]

🎉 Proud to share our latest paper, in @NatureAging, in which we identified BMPs (the lipids, not the protein) as a class of aging lipids in mice and humans ⬇️

https://t.co/HLKfuZEnC6

[Science Magazine @ScienceMagazine]

A flexible electronic fiber that utilizes the human body as part of the circuit enables textile-based electronics without the need for batteries or chips, researchers report in Science.

Learn more: https://t.co/AHAwdnCiem

[Prof Andrew Murphy @AJMurph5]

Now out in @NatureCellBio Please see thread below. Thanks to the amazing team and collaborators!! Our website is also live (https://t.co/1S6ISEawln)
https://t.co/mjXh4zgOkc
https://t.co/JagGjR9mYB
@BakerResearchAu
Still a lot more to discover lipids and immune cell function!

[Cell Metabolism @Cell_Metabolism]

New! Online now: Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity https://t.co/1MOMNgAtjp

[The Tatva @thetatvaindia]

Shocking scenes from inside the Indian Parliament after #SecurityBreach in #LokSabha

[Cell Metabolism @Cell_Metabolism]

GDF15 is a major determinant of ketogenic diet-induced weight loss https://t.co/ePyEe4yuRt

[Cell Metabolism @Cell_Metabolism]

Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses https://t.co/x49kpGLkWq

[Yuyang Liu @YuyangLiu1996]

(Thrilled to have my first Twitter Thrill) Thrilled to share my first paper published today ⁦@ScienceMagazine⁩. How does a cell monitor metabolic homeostasis across so many subcompartments? We tried to offer a hint by looking at GSH in mitochondria. https://t.co/BjEkfL7Ey1

[TheLiverDoc™ @theliverdoc]

This is probably the craziest proprietary herbal product I have ever come across in my profession as a clinical researcher studying and analysing herbal and dietary supplements and liver damage since six years.

A young woman consumed this continuously for a month and then intermittently for few weeks for "general wellness."

The outcome:
Bilirubin (marker of jaundice): 24 mg/dl --> (normal is 0.8-1.2)
ALT (liver enzyme) 1045 U/L --> (normal is <40)
AST (liver enzyme) 889 U/L --> (normal is <42)

Check out the ingredients:
39 (!!!) herbs plus 4 preservatives

Huge red flag in the ingredients:

[1] Guduchi/ Giloy or Tinospora cordifolia - the best documented, most studied, well confirmed cause of severe hepatitis
See here: https://t.co/DsMdcLxVsq, here https://t.co/HPJbgCbTOf, here https://t.co/WidnnqOTLv, here https://t.co/Z3KlKaWLDD, and here https://t.co/YRPLOck8R0

[2] Ashwagandha or Withania somnifera - one of the biggest upcoming causes for severe liver injury in developed and developing nations. Ashwagandha also contains withanone which can damage DNA and can promote cancer developement. Denmark has banned Ashwagandha supplements and many EU countries are contemplating ban on Ashwagandha.
See here: https://t.co/g1UVeRVCHq, here: https://t.co/TUEvPOWfqx, here: https://t.co/bL7bgRsURE and here: https://t.co/ssvtVm0MV9

[3] Bilva or Aegele marmelos - contains ageline, one of the most well known liver toxic agent, its synthetic version is banned by the US FDA as dietary supplement.
See here: https://t.co/ToPF5xA5On

[4] Goksura or Tribulus terrestris - causes liver injury due to the presence of phylloerythrin and beta-carboline alkaloids in the plant
See section on Tribulus here: https://t.co/JYg4z4ZWNs

[5] Aloe vera or Aloe barbedensis - well reported cause for severe hepatitis
See section on Aloe here: https://t.co/JYg4z4ZWNs, here https://t.co/2PEn4PAbjd, here https://t.co/gjaZ9d9s9y, here https://t.co/Dz0hrLnEuf, here https://t.co/macqsKjw6j and here https://t.co/BwdddoKd0C

These have been shown to cause severe liver injury as singular agents - now imagine them ALL together in this product and the risk of liver injury as was noted in this patient.

As always - please be aware of ingredients in your herbal supplements. Do not consume complex multiherbal products or products with known liver toxic ingredients. Multiherbal products have no clinically proven benefits and can land you with severe adverse events.