Tautaton

Neuroscience, immunology. Tau, viral infection, cGAS-STING.

[Tautaton @tautaton]

✨Tau spreading coordinates intercellular lipid flux enhancing neuronal resilience to lipid toxicity https://t.co/PPpc5ARkgZ

[Tautaton @tautaton]

Circulating Cell-Free Chromatin Particles Trigger a Unique Biphasic STING Signaling Program that Drives DNA Damage and Inflammation https://t.co/Cd7LhK0NYx

[Rishi Bedi @rishibedi]

Elegant demonstration that immune cells from the periphery infiltrate the aging brain. The possibility that modulating peripheral immunity could affect neurodegenerative disease opens up a whole new control surface for therapeutic intervention.

[John Lukens @LukensJohnR]

Transcriptional regulation of disease-relevant microglial activation programs: Neuron https://t.co/gFBhBC84m4 @NeuroCellPress

[Tautaton @tautaton]

💫Cytoplasmic DNA Sensing Links LINE-1 Expression to Neuronal Senescence in Alzheimer's Disease https://t.co/V75Yspebzv
„these findings establish a LINE-1/cGAS-STING axis as a driver of neuronal senescence in AD and highlight LINE-1 inhibition as a tractable senomorphic strategy“

[Danielle Beckman @DaniBeckman]

Science is full of surprises. We expect vascular loss during aging, but what if some brains instead become hypervascular, a state linked to inflammation & cognitive decline? Activating Tie2 path lead to reversed some pathology. Exciting neuroscience!
https://t.co/MNTYhftOb6

[TNia @Dr_Tnia]

Epigenetic and 3D genome reprogramming during the aging of the human hippocampus | Science https://t.co/iY29RZl8dc

[Tautaton @tautaton]

Microglia extract neuronal proteolytic organelles via skoupocytosis https://t.co/bCJjgQrMtg

[Tautaton @tautaton]

Modulation of retroviral capsid assembly halts ARC-mediated TDP-43 intercellular spreading
https://t.co/5rRcjEI9YT

[Jason Shepherd @JasonSynaptic]

Great write-up on our recent paper on tau transmission! This is just the beginning...the intersection with viral infections is an emerging causal route to neurodegeneration IMO. Another preprint that just came out suggests Arc capsids may ALSO transfer TDP-43 🤯 See link below.

[Ranabir Chakraborty @_ranabir]

The final version of our study on inflammatory regulation of tunneling nanotubes between neuronal cells and microglia is now out in @NatureComms. We identified the cGAS-STING pathway to positively regulate functional connections between these cells
https://t.co/3QsP1L62eR

[ShorterLab @ShorterLab]

SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain | Science Advances https://t.co/VxhcNrtI3I

[Tautaton @tautaton]

Loss of m6A unmasks a senescence-associated inflammatory program in human microglia https://t.co/T3poe5zsbD

[The Science of Parkinson's @ScienceofPD]

By analyzing #Parkinsons patients & LRRK2 gain-of-function mice, researchers proposed that PD represents an accelerated aging disorder driven by STING-dependent inflammation
https://t.co/wmngajjngv

[Tautaton @tautaton]

Humanized tauopathy chimeras uncover microglial and lncRNA strategies for neuroprotection https://t.co/uAgi72VTEr

[Tautaton @tautaton]

The NORAD-pumilio regulatory axis links lncRNA dysregulation to tau propagation-associated phenotypes https://t.co/Dm6mmcQ44b

[Tautaton @tautaton]

💫 interesting paper, e.g.:

[John Lukens @LukensJohnR]

Arc mediates intercellular tau transmission via extracellular vesicles. @CellCellPress https://t.co/Z4I8f3DwaN

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Delighted to share a News & Views w/ @Dr_LPJ just out in @NatureNeuro 🧠

It grew from a deceptively simple question: what happens to the brain's immune cells when their mitochondria are under stress?

https://t.co/AIVLjV8pqc

[Tautaton @tautaton]

INPP5D/SHIP1 regulates endo-lysosome function and cargo-selective phagocytosis in human microglia https://t.co/gYQmwO29N7

[John Lukens @LukensJohnR]

Targeting the cGAS–STING pathway mitigates Huntington disease pathogenesis in a knock-in mouse model | PNAS https://t.co/88UsBhI5Pz