Peter Choi

Assistant Professor @PennMedicine and @ChildrensPhila | Interested in cancer genetics and RNA biology

[Peter Choi @thechoilab]

First paper from the lab out in @CellReports! (https://t.co/ndJiJqF1tI) A great collaboration with @srviswanathan and many others, check out his tweetorial 👇 for more info

[Srinivas Viswanathan @srviswanathan]

Happy that, on this numerically special Tuesday (2/22/22!), our work with @thechoilab on PRMT1 as a vulnerability in prostate cancer is published in @CellReports: https://t.co/09dv0K7Sdy #prostatecancer #pcsm @CaP_Pubs A 🧵 (-2/7)

[SheqLab @ShechnerLab]

Beyond thrilled to present our O-MAP—now *published* @naturemethods (!!!)

O-MAP is a powerful new method for biochemically "dissecting" the subcellular microenvironment around an RNA of interest, using off-the-shelf parts and standard manipulations. 🧵
https://t.co/gBGsQ6dBs9

[Yoseph Barash @YosephBarash]

📣 If you are interested in #RNA #Splicing using long or short #RNASeq check out our recent paper on combining and contrasting short and long reads for this https://t.co/zDsTkkDk1a - we think there are some important lessons for where/how you invest time/💰 🧐and...

[Srinivas Viswanathan @srviswanathan]

Our paper on how X chromosome alterations drive sex differences in translocation renal cell carcinoma is now out in print @CellCellPress! Link to explainer thread if you missed it 👉: https://t.co/cfJbclDdwR

[Gene Yeo’s Lab at UC San Diego @yeo_lab]

Our latest work is now published in @MolecularCell! We discovered new RNA-binding zinc finger proteins and demonstrated their functions in RNA splicing, stability, and polyadenylation. Congrats to 1st author @MayaGosztyla and our fantastic collaborators. https://t.co/4TJszoFvzs

[Eduardo Eyras @EduEyras]

R2Dtool https://t.co/czxyDjWT94 for handling, integrating, and viualising isoform-resolved RNA feature data - led by @_AJSethi #bioinformatics #RNA #isoforms
https://t.co/wPGGZxHarv

[Yoseph Barash @YosephBarash]

If you want cutting edge #RNA #Therapeutics leading academia/industry (Adrian Krainer, @IMMolecular, @karni_rotem, @envisagenics, @RemixThera, @mirimiam, @LevanonLab, etc.) this is great location (Porto Portugal) & perfect time (Sep 25-27) - see 👇😀 https://t.co/aYU6XvgrbA

[Ophir Shalem @ophirshalem]

Excited to share this collaboration spearheaded by @GMBurslem lab! Part of our long term goal of developing tools for scalable and non-disruptive perturbation and imaging of the endogenous proteome!

[Gene Yeo’s Lab at UC San Diego @yeo_lab]

Dysfunction of protein-RNA interactions is linked to human diseases. Pleased to share our review on "Decoding protein-RNA interactions" with discussions on therapeutic applications from knowledge of protein-RNA interactions @NatureRevGenet https://t.co/cBRWJ3fFw2

[Arjun Raj @arjunrajlab]

Excited to launch our cloud-based image analysis platform today at https://t.co/sXb3CPV5B4! Analyze and interact with your data, all in the browser. Follow sign-up instructions to request an account.

[The Blencowe Lab @ U of T @Blencowe_Lab]

Graduate student Jack Li's work out in Molecular Cell now: By conducting a screen of 341 splicing factors, Jack identified RBM25 coupled to dCasRx as a superior tool to boost inclusion of endogenous exons /1

[Charles Swanton @CharlesSwanton]

Why do some patients benefit less than others from precision cancer medicine? We are excited to share our paper "Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling” out in @NatureComms. https://t.co/e5AYdyrnbx 🧵

[Stirling Churchman @fiddle]

If you’re interested in what the last few years have taught us about the process of splicing, check out our latest review!Congratulations to my co-authors @HopeMerens @karine_choquet @Autum_BaxterKoe

[Chaolin Zhang @chaolinzhang]

Our SpliceRUSH paper is officially out! If u have an RBP and would like to map its targets, u will think of CLIP. What if u have your favorite gene (e.g., a drug target) and want to map all the splicing-regulatory elements? SpliceRush is just for this!
https://t.co/9H0pZd3QMa

[J. Keith Joung @JKeithJoung]

Excited to share a new preprint (https://t.co/nPXJf7FW19) describing Precision Editing of Regulatory Sequences to Induce Stable Transcription-On (PERSIST-On), a hit-and-run strategy that enables robust and stable heritable gene activation in human cells. 1/15

[Lukasz Bugaj @BugajLab]

Our 2nd preprint on thermal control of cells🔥: Below: dynamic thermal induction of stress granules, enabled by new hardware from @WillBenman.

Why don’t SGs form during every heat pulse?👇

https://t.co/nj6jXNzc47

[Faraz K Mardakheh @FKHM]

Very excited to share our paper out today in @naturemethods, introducing TREX (Targeted RNase H-mediated Extraction of X-linked RBPs), a novel approach to reveal proteins that bind to any region of any RNA molecule of interest in living cells🧪: https://t.co/rVU8X9W0ED (1/10)

[Ben Kleinstiver @BKleinstiver]

SpRYgests now enabled via purified SpRY protein through @NEBiolabs, available here:
https://t.co/X1vKDlzvqe

Super cool to have this option 'live' now - congrats to @russelltwalton @katieachristie @RomanMDoll & many others who contributed.

Happy SpRYgesting 😃

[Yoseph Barash @YosephBarash]

How do STAR (settings) affect RNA splicing analysis? https://t.co/s8ExHHayB4

[UPenn GCB @UPennGCB]

Kevin Yang of the Barash (@YosephBarash) and Choi (@thechoilab) Labs defends his thesis tomorrow! #AlmostPhDone

[Jeremy Wilusz @JeremyWilusz]

Our center at Baylor College of Medicine in Houston is hiring more faculty in RNA Biology. Application deadline is October 20. https://t.co/CHcup6N5Wy