Thirupugal Govindarajan, PhD

Scientist working on regenerative cell therapy for cardiomyopathy and muscular dystrophy.

[Dan Nomura @DanNomura]

Excited to highlight our newest work on an induced proximity-based targeted transcriptional repression platform termed Transcriptional Repression via Active Chemical Epigenetic Reprogramming (TRACERs)! Congrats to @CEStieger and co-authors and our @NovartisScience collaborators!! (1/9)
https://t.co/c0z00qn3s6

[Thirupugal Govindarajan, PhD @thirupugal]

LARP7 promotes postnatal cardiac regeneration by facilitating G2/M phase transition - Journal of Molecular and Cellular Cardiology https://t.co/6iMqAqCzzi

[Dan Landau @landau_lab]

Exciting breakthrough technology from the lab, now live in @CellCellPress ! Instead of cutting the genome where proteins bind (e.g., Cut&Tag), D&D-seq scars the DNA with a deaminase, allowing single cell genome mapping of TFs and chromatin remodellers!

[Thirupugal Govindarajan, PhD @thirupugal]

Boy’s brain tumor tied to gene therapy | Science | AAAS https://t.co/5STAnG2G1P

[Thirupugal Govindarajan, PhD @thirupugal]

Mechanical load inhibits cancer growth in mouse and human hearts | Science https://t.co/XgVp2mnUWF

[Thirupugal Govindarajan, PhD @thirupugal]

Genome pioneer Craig Venter dies: here’s how he transformed science https://t.co/ZzYt34C0fJ

[American Heart News @HeartNews]

American Heart Association honors legacy of pioneering cardiologist
https://t.co/NbmSbT1unE

[Kika @v_moreno_juan]

I am very happy to share that our paper is now published in @Nature 😊
Cell-type-targeted mitochondrial transplantation rescues cell degeneration.
https://t.co/lQACEJLDwg
@IOB_ch (1/6)

[Emma Lundberg @Prof_Lundberg]

What would it look like to see all ~13,000 proteins inside a single human cell at once?
We share ProtiCelli — a generative model that makes this possible. Besides benchmarking, we demonstrate utility in many tasks.

Preprint: https://t.co/faBevXiBBa
A thread 🧵👇

[Nature Cardiovascular Research @NatureCVR]

❤️Our March issue is out❤️Read about an AI model using echocardiography images improves cardiac diagnosis, LVAD unloading alleviates cellular senescence, inhibition of a hematopoietic death regulator shows cardioprotection, and more.

https://t.co/lMEE4jJVgB

[Thirupugal Govindarajan, PhD @thirupugal]

Ex-vivo culture of human hypertrophic cardiomyopathy hearts: Functional and metabolic changes during long-term culture: iScience https://t.co/UTyIepNRlf

[Ezequiel Dantas @eze_dantas]

"Short-term fasting induces intratumoral accumulation of isoleucine, which reconfigures CD8+ T cell epigenetic programs and phospholipid remodeling, thereby licensing enhanced anti-tumor capacity."

[Ke Cheng, Ph.D. @KeChengLab]

Congratulations to Kaiyue Zhang on the publication @ScienceMagazine. In the paper, we built an “RNA factory” on muscle for heart repair. https://t.co/DRDhOLKbLl

[Circulation Research @CircRes]

Omoto et al reveal activating #leptin signaling in the #brain helps the #heart heal after ischemic injury by sending signals to #BrownFat to reduce scarring & improve heart function. Learn about a new brain–fat–heart communication at https://t.co/Bhi8vSQ6rM
@CVIRLab

[Journal of Clinical Investigation @jclinicalinvest]

This muscle cell gatekeeper has implications for a broad range of muscle-related conditions.

Using murine and human models, Siwen Xue @siwen_xue Daniel C. Berry @dcberrylab & team @WeillCornell show block of the protein PDGFRbeta enhances myofiber repair and regeneration, whereas activation of it slows down recovery by limiting cell size and fusion: https://t.co/kk98Vdlchy

The image shows muscle regeneration in mice treated with the PDGFRbeta inhibitor SU16f.
#myotwitter

[Nature Metabolism @NatMetabolism]

RESEARCH | @thebioKIMist @JasonRCantor et al. (@Morgridge_Inst):

Differential localization of the hexokinase HK1 isoform compared to the HK2 isoform, explains the conditional essentiality of HK2 in cancer cells cultured in physiologic media.

https://t.co/9DluG7FUQZ

[Matthias Mann Lab @labs_mann]

Ever wondered how the human liver looks like at single-cell, spatial protein resolution? We used single-cell Deep Visual Proteomics to map human liver zonation at the protein level - one hepatocyte at a time. Our paper is out in @NatMetabolism!
https://t.co/VbSqyHnSTq

[Genetics at BMC @OAgenetics]

Check out Skeletal Muscle's Featured Article:

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle

@KevinMurachPhD

➡️Read more: https://t.co/HH2lq5F8G5

[The Hornberger Lab @HornbergerLab]

Thrilled to share our new @ScienceAdvances paper where we provide evidence that mechanical stimuli drive skeletal muscle growth through TWO distinct mechanisms—and use BONCAT to visualize where the growth occurs. Take a look: https://t.co/Hk6SpXK5aJ

[Ildus I. Ahmetov @SportsGenomics]

Mechanical loading induces the longitudinal growth of muscle fibers via a rapamycin-insensitive mechanism

https://t.co/35RfUBjTpX