Tim Moors

[Dr. Saranna Fanning, Ph.D. @SarannaFanning]

Are you interested in pursuing research to identify therapeutic targets for neurodegenerative diseases? The Fanning lab has postdoc positions to pursue the role of lipids and the metabolome in disease.

[Tim Moors @tmoors1]

@M_B_Miller Fantastic, huge congrats!!

[Roos Jutten @RoosJutten]

Hot off the press! Our group's latest work on daily, brief, remote digital testing to detect the earliest cognitive signs of Alzheimer's disease: https://t.co/EqpZFg4zSD @HarvardAging @BRANCH_Harvard @CognitionPia @Teleneuropsych @TechnologyPIA

[Tim Moors @tmoors1]

@Roy_Lab_Thinks @leonardoaparrar @EmmaVIDALL Congrats! Beautiful cover and very interesting findings

[Dr. Laura Jonkman @NeuroLaura]

Vacancy alert 🚨@LabBerg is looking for a postdoc studying Parkinson’s disease mechanisms. Do you have experience with live-cell imaging microscopy and spatial transcriptomics? Do not hesitate to reply!

https://t.co/ufcQnIqGiO

[The Science of Parkinson's @ScienceofPD]

New research from @tmoors1 & colleagues reports that increased palmitoylation improves estrogen receptor alpha–dependent hippocampal synaptic deficits in a mouse model of synucleinopathy; ML348 (de-palmitoylation inhibitor)⬆️ERα & soluble αsyn homeostasis
https://t.co/2Yk2w3zRtO

[Tim Moors @tmoors1]

Better understanding of estrogen-related pathways underlying protection of synapses against pathological effects of alpha-synuclein is relevant for human PD given male preponderance, the preservation of which may represent an opportunity for future treatment strategies (3/3)

[Tim Moors @tmoors1]

In our latest work, we studied underpinnings of sex differences in transgenic mice expressing "3K" mutant alpha-synuclein. We found that hippocampal synaptic deficits in males were improved by estrogen, mediated by estrogen receptor (ER) alpha (1/3)
https://t.co/vIetYkpEgw

[Tim Moors @tmoors1]

We observed synaptic distribution of ER alpha was impacted by alpha-synuclein aggregates, paralleled by its decreased palmitoylation. When treating 3K mice by inhibiting APT1 -increasing palmitoylation of substrates as ER alpha- phenotypes/alpha-synuclein solubility improved(2/3)

[Tim Moors @tmoors1]

@AbidOueslati @GaryHoLab @Nag2023 @DettmerUlf It was wonderful to have you over @AbidOueslati! Thanks for the great discussions!

[bioRxiv @biorxivpreprint]

Altered TFEB subcellular localization in nigral dopaminergic neurons of subjects with prodromal, sporadic and GBA-related Parkinson's disease and Dementia with Lewy bodies https://t.co/tZJcg1tacD #bioRxiv

[Vik Khurana Lab @khurana_lab]

Our lab is looking for an RA and postdoc for projects related to the molecular and cellular biology of #synuclein #Parkinsons building upon several recent papers (https://t.co/4L8JppyRO6). Please spread the word!

[Tim Moors @tmoors1]

@BWHNeurology @harvardmed Huge congrats, Erinc! 👏

[Andrew Stern, MD PhD @andrewmstern]

We are #hiring a #postdoc to study the biochemistry of diffusible toxic amyloid species in the human #Alzheimer brain, including work on #lecanemab and #donanemab. Please DM and/or retweet!

[Gary Ho, MD, PhD @GaryHoLab]

I am proud to share our most recent work on synaptotagmin-11 and #palmitoylation in #Parkinsons, which is featured on the cover of this week's @scisignal. #neurotwitter [1/8]
https://t.co/rQAHn3nzZd

[Alzforum @alzforum]

More than a marker of Lewy bodies, phospho-serine 129 α-synuclein reflects normal neural activity. In mice, p-S129syn enables neurotransmission and strengthens synaptic plasticity. @BrighamWomens @UCSanDiego https://t.co/yxAxibzu6S

[The Science of Parkinson's @ScienceofPD]

Researchers report a site-specific, reversible phosphorylation of the #Parkinsons-associated protein α-synuclein at Serine129 which occurs physiologically during neuronal activity; "Adds nuance to the interpretation of pS129 as a synucleinopathy biomarker"
https://t.co/uwDrH44qNv

[Dr. Saranna Fanning, Ph.D. @SarannaFanning]

**Postdoc Opportunity**. Are you interested in being part of exciting research identifying new therapeutic targets for Parkinson’s disease in the area of lipid biology? Come join our team as a postdoc. DM or email for additional details

[Tim Moors @tmoors1]

Interesting read - The Misunderstood Proteins of Neurodegeneration https://t.co/MGfXF6G9C2