Are you interested in pursuing research to identify therapeutic targets for neurodegenerative diseases? The Fanning lab has postdoc positions to pursue the role of lipids and the metabolome in disease.
Vacancy alert 🚨@LabBerg is looking for a postdoc studying Parkinson’s disease mechanisms. Do you have experience with live-cell imaging microscopy and spatial transcriptomics? Do not hesitate to reply!
https://t.co/ufcQnIqGiO
New research from @tmoors1 & colleagues reports that increased palmitoylation improves estrogen receptor alpha–dependent hippocampal synaptic deficits in a mouse model of synucleinopathy; ML348 (de-palmitoylation inhibitor)⬆️ERα & soluble αsyn homeostasis
https://t.co/2Yk2w3zRtO
Better understanding of estrogen-related pathways underlying protection of synapses against pathological effects of alpha-synuclein is relevant for human PD given male preponderance, the preservation of which may represent an opportunity for future treatment strategies (3/3)
In our latest work, we studied underpinnings of sex differences in transgenic mice expressing "3K" mutant alpha-synuclein. We found that hippocampal synaptic deficits in males were improved by estrogen, mediated by estrogen receptor (ER) alpha (1/3)
https://t.co/vIetYkpEgw
We observed synaptic distribution of ER alpha was impacted by alpha-synuclein aggregates, paralleled by its decreased palmitoylation. When treating 3K mice by inhibiting APT1 -increasing palmitoylation of substrates as ER alpha- phenotypes/alpha-synuclein solubility improved(2/3)
Altered TFEB subcellular localization in nigral dopaminergic neurons of subjects with prodromal, sporadic and GBA-related Parkinson's disease and Dementia with Lewy bodies https://t.co/tZJcg1tacD #bioRxiv
Our lab is looking for an RA and postdoc for projects related to the molecular and cellular biology of #synuclein#Parkinsons building upon several recent papers (https://t.co/4L8JppyRO6). Please spread the word!
We are #hiring a #postdoc to study the biochemistry of diffusible toxic amyloid species in the human #Alzheimer brain, including work on #lecanemab and #donanemab. Please DM and/or retweet!
I am proud to share our most recent work on synaptotagmin-11 and #palmitoylation in #Parkinsons, which is featured on the cover of this week's @scisignal. #neurotwitter [1/8]
https://t.co/rQAHn3nzZd
More than a marker of Lewy bodies, phospho-serine 129 α-synuclein reflects normal neural activity. In mice, p-S129syn enables neurotransmission and strengthens synaptic plasticity. @BrighamWomens@UCSanDiego https://t.co/yxAxibzu6S
Researchers report a site-specific, reversible phosphorylation of the #Parkinsons-associated protein α-synuclein at Serine129 which occurs physiologically during neuronal activity; "Adds nuance to the interpretation of pS129 as a synucleinopathy biomarker"
https://t.co/uwDrH44qNv
**Postdoc Opportunity**. Are you interested in being part of exciting research identifying new therapeutic targets for Parkinson’s disease in the area of lipid biology? Come join our team as a postdoc. DM or email for additional details