Trefely Lab

Studying metabolic compartmentalization and metabolite signaling to the nucleus @BabrahamInst

[Trefely Lab @trefely]

We have an exciting postdoc opportunity at the interface of metabolism and epigenetics! 🔥🧬

The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️

For more detail and to apply:
https://t.co/IKMJmMAQMo

[Trefely Lab @trefely]

Calling metabolism enthusiasts looking for a PhD opportunity!

We have an exciting project in partnership with DefiniGEN

Applications close Nov 24th

https://t.co/b8JONSGG5G

[Trefely Lab @trefely]

@JuliannaSupplee @WellenLab @MarmorsteinLab Congratulations @JuliannaSupplee 🎉
Beautiful work

[BSI Congress & Events @bsicongress]

📣Only 1 week left to submit an abstract for the UK's leading #immunometabolism event!

#UKimmunomet24 will be packed with cutting-edge #research, plenty of networking & 'Bright Sparks' sessions for #ECRs 🌟

Submit your abstract by Friday 15 March 👉https://t.co/qsii35trdc

[Trefely Lab @trefely]

@doc_jlmeier @therealdiehllab @uofupharmacy 🙌

[Trefely Lab @trefely]

@irene_zorzan @AmyWilkinson25 @RuggGunnLab Congrats! 👏

[Trefely Lab @trefely]

@WellenLab @BMBGGUPENN Congratulations Joyce! 🌟

[Trefely Lab @trefely]

@MathiasWenes @MiglioriniDenis @ArberCaroline @AlisonJaccard @PCHo_Lab @UNIGEnews @OncoUNILCHUV Congrats 👏

[Trefely Lab @trefely]

@AlisonJaccard Congrats!

[Trefely Lab @trefely]

@DPhaz Congrats 🙌

[Trefely Lab @trefely]

@propionylCoA Congratulations Mary 👏🌟💫

[Trefely Lab @trefely]

@AZadoorian22 @NatureRevEndo @rob8yang @ximingDu @UNSWBABS @UNSWScience @UNSW A great resource, congrats @AZadoorian22 @ximingDu and @rob8yang 👏

[FrezzaLab @FrezzaLab]

Good morning all! A very Ac-CoA-rich summary of papers in #cancermetabolism and #mitochondrialbiology is out now, don't miss it: https://t.co/NiZair3stD @Bims_BiomedNews

“The truth is not always beautiful, nor beautiful words the truth.”
― Lao Tzu

[Trefely Lab @trefely]

@Gerta_Hoxhaj @AranyLab @mzspectrum @WellenLab Thank you 😊

[Trefely Lab @trefely]

Can histone deacetylation fuel acetyl-CoA metabolism?
We teamed up with Ioana Soaita @AranyLab @mzspectrum @WellenLab to answer this question.

https://t.co/Z3Yxo7Uuwf

[Trefely Lab @trefely]

@PatVargaWeisz @AranyLab @mzspectrum @WellenLab Thank you!

[Trefely Lab @trefely]

So the contribution of deacetylation to whole cell acetyl-CoA metabolism appears limited 🥲Although the contribution may vary across subcellular compartments.
Variation in the extent of deacetylation between different histone lysine sites suggests selectivity in this response:

[Trefely Lab @trefely]

We didn't detect any release into extracellular acetate, so we checked 13C-labeling. We found that up to ~10% of the acetyl-CoA pool was derived from deacetylation, and this label was transmitted downstream into (iso)butyryl-CoA!

[Trefely Lab @trefely]

Our data are consistent with a model where acetate is preferentially mobilized to maintain other acetylation events (such as shown recently by Mendoza et al @berger_lab @GarciaLabMS)
https://t.co/FujAjhbZGD