🎙 Randomized Trial 🚨: SBRT vs. RFA for Recurrent Small HCC—Is It Time to Rethink Local Treatment? @OncoAlert
🔬 Study Highlights:
📌 Phase III trial, 166 👥 with recurrent HCC (≤5 cm, single lesion).
📌 Randomized to RFA (n=83) or SBRT (n=83)
Key Outcomes:
✅ Local progression-free survival (LPFS):
•2-year LPFS: 92.7% (SBRT)🏆 vs. 75.8% (RFA) (HR: 0.45, p=0.014).
✅ Progression-free survival (PFS):
•Median PFS: 37.6 months (SBRT) vs. 27.6 months (RFA) (p=0.19).👌
✅ Overall survival (OS):
•2-year OS: 97.6% (SBRT) vs. 93.9% (RFA) (p=0.83).👌
✅ Safety: Comparable acute and late adverse events.👍
📣 Implications for Practice:
SBRT demonstrated ⬆️ local control while maintaining similar safety and OS compared to RFA.
Finally published. 👇🏼👇🏼
SWOG S1815: A Phase III Randomized Trial of Gemcitabine, Cisplatin, and Nab-Paclitaxel Versus Gemcitabine and Cisplatin in Newly Diagnosed, Advanced Biliary Tract Cancers @JCO_ASCO https://t.co/OCPmKc6Mfk
RACE-GB is out! Congrats to authors for FIRST RCT of RT in gallbladder cancer.
N=135 w unresectable GBC, after 4c chemo, addition of RT (vs. obs) improved OS from 4 to 10 months.
Several limitations (single center, chemo gem/cis & 4 mo) but OS benefit shouldn’t be ignored.
First-Line Systemic Treatment for Initially Unresectable
CRC Liver Metastasis
🔎Post Hoc CAIRO5
@JAMAOnc
https://t.co/dqMQ5AD4Mo
👉FOLFOX or FOLFIRI plus Bev seems to be an option for all pts
👉Excellent OS for pts with early recurrence & salvage local Tx
@myESMO
🚨 Don’t miss this ! Join us Wed. Nov 13, 6:30-8pm EST for a powerful webinar on Advances in HCC/Biliary Tract Cancers. Learn from top experts on treatments, trials & patient perspectives.
👉 Register now: https://t.co/QLuyGxX2t7
#HCC#BiliaryCancer#HPB#HPBSurgery
Addition of Metastasis-Directed Therapy to Systemic Therapy for Oligometastatic Pancreatic Ductal Adenocarcinoma
@JCO_ASCO
https://t.co/2E3xz6ChPJ
🔎EXTEND phs II, 41 pts, ≤five mets
👉PFS 10.3 vs 2.5 mo
🧐local intervention plus CTx in oligometastic #PDAC promising, but no OS benefit
@myesmo
Delighted to open the surgical program on the
rationale and benefit of lymphadenectomy in
#cholangiocarcinoma at 7th Annual AP 🇰🇷
@curecc Conference
🙏🏼@eugenekoay & Dr. Oh for 📨
Is it merely a staging tool?
How many nodes are necessary?
Does tumor location play a role?
Deadline Approaching! 📢📢
Submit original research & be featured at #AHPBA25@FlavioRochaMD @drsuswarner @megimenez
Submit Here: https://t.co/QtvP9T2z2x
Our HPB Surgeons @ProvHealth Dr.'s Jon Gerry and John Creasy raising awareness on HPB diseases on @KATUNews !
@rbryanbell@ProvHealthNews@AHPBA@IHPBA
Providence Cancer Institute: Hepatobiliary Cancers and What to Look For https://t.co/LmeaA9OVo0
💫Highlights from the @hpbjournal: Multimodal treatment for HCC >1️⃣0️⃣cm.
🇫🇷review&meta-analysis: 1️⃣3️⃣ studies
⬆️OS for resection✚TACE vs resection alone!
🤔 Pre-op TACE beneficial?
🤔 TACE for recurrence 👉OS ⬆️?
https://t.co/oUJ1HemYaK
@ihpba@ProfW_Edinsurg@cherchiandrea
SPEAKER ANNOUNCEMENT ‼️
Our next speaker is @DavidCabaMD who is the Assistant Professor of the Department of Surgery of the Division of Surgical Oncology at LLUMC.
Associate Program Director Complex Surgical Oncology Fellowship at LLUM.
#SurgicalPanel#nyc#surgery#MedTwitter