I was on call on oncology when my thesis work came out - I guess I'm actually becoming a physician scientist? Delighted to share this work and incredibly grateful to all those who made this possible, in particular my advisors @anshulkundaje and Paul Khavari. #ML#genomics
🔥HOT OFF THE PRESS🔥 @NatureGenet from @WJGreenleaf@anshulkundaje , Paul A. Khavari, and colleagues:
👉The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation
🔗https://t.co/dJauetVDZJ
Excited to share our paper out today in @ScienceMagazine! We directed high-content, single-cell genetic screens to ask how a disordered adapter protein orchestrates the complex process of T cell activation. (1/4)
https://t.co/63pYd3UalF
Thrilled to share our new @NatureGenet paper! We mapped human skin at single-cell spatial resolution and found that anatomy is encoded in cell states and neighborhoods, led by PhD student @paularstrpo. Link: https://t.co/mBTaLUix3A
1/9
Excited to share our study of T cell signaling, where we directed high-content, single-cell genetic screening to uncover how a single adapter protein orchestrates a complex cellular process essential for health. (1/14)
https://t.co/MmGF01YVLn
1) Super excited that COVET and ENVI by the gifted @DoronTheViking finally out in @NatureBiotech providing a powerful tool to analyze the rapidly accumulating spatial transcriptomics data. See https://t.co/U6C7zQ0OTS for the original BioRxiv tweetorial -->
We are very excited to present a major breakthrough achievement – the de novo design of synthetic enhancers for selected tissues in fruit fly embryos in vivo using deep- and transfer learning, @deAlmeida_BPet al published today in @Nature https://t.co/TIlPrBKYaK. Thread 👇(1/N)
Exciting news! Our latest research on "Cell type directed design of synthetic enhancers" has been published in @Nature. We've harnessed deep learning to design enhancers with cell-type specificity. Find our paper here: https://t.co/wC44fDMp70. Highlights below: [1/n]
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent immune response against a distant tumor. @yerinchen led the charge w/ help from @DjenetBousbaine, @VeinbachsA, @BelkaidLab. @ScienceMagazine 1/26
https://t.co/bgW3C7CJgh
We published a paper
"Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease" 1/
https://t.co/B425gbsNwJ
DOI: https://t.co/M3sGpiWPle
@anshulkundaje@midjourney_ai Congratulations!! Thanks for taking on a very clueless grad student all those years ago - I would never have done ML or become a comp bio person if it weren’t for my time in the lab.
i'm on vacation now after a hectic season of fellowship apps, inpatient time, on-call nights, and finally catching up a little on #ML#science - and WOW we got crazy text generation #ChatGPT; image generation #dalle; and even PROTEIN GENERATION @UWproteindesign@generate_biomed
Was about to start the Road to Hana #Maui when we stopped to get the match results - so thrilled to be going to @MSKCancerCenter for Heme/Onc! So grateful to all my mentors and community @StanfordMedRes@anshulkundaje Paul Khavari #StanfordMSTP. Excited for this new adventure!
This morning at the Illumina Genomics Forum, we unveiled our fastest, most cost-efficient sequencing machine yet – the NovaSeq X series. This technology will slash the cost to $200 per human genome and provide a readout at twice the speed. @WIRED feature: https://t.co/AeIizKAzio
What are the rules of enhancer syntax? How flexible/constrained TF motif positions within enhancers are? How does the sequence context modulate the contribution of motifs to enhancer function?
Excited to share our work together with @reiterfanny addressing these questions!
1/19
Excited to share our work on using deep learning to predict enhancer activity from DNA sequence, learn cis-regulatory rules and the importance of TF motif instances, and design synthetic enhancers with desired activities.
@reiterfanny@stark_lab
(1/16)
https://t.co/h5koYdlXya
The @stark_lab at the IMP has developed a deep learning model, DeepSTARR, which predicts the activity of enhancers from their DNA sequence with exceptional accuracy. Now published @NatureGenet.
The paper 👇🏾 [1/n]
https://t.co/jWTj1JaETS
this tweet is dedicated to my patient for whom we finally got the properly sized catheter. i never expected to learn so much about hospital supply chains
an observation: in medicine we often extend ourselves to perform logistical miracles for our patients' care - which is great training for getting things done, but not gonna lie it's also kinda harrowing 😅 #internyear#medres#wheredidallthesegrayhairscomefrom