Vish Chandrasekaran

Senior Investigator Scientist @MRC_LMB
Structural Biologist

[Sethu Pitchiaya @SethuPitchiaya]

The Pitchiaya lab is #hiring! We seek to hire a #Postdoc to work on exciting projects pertaining to stress response mechanisms in cancer - https://t.co/6RzrQa3OLx. Email/DM for more info. @UMichPath @UMRogelCancer @umichrna @UMichResearch @umichmedicine

[Green Lab @GreenLabJHMI]

We’re excited to share our study in @CellCellPress on the role of the MAP3 kinase ZAK in UV-induced apoptosis led by @2primehydroxyl! We studied cell signaling kinetics following UV-damage and found that ZAK drives apoptosis via ribosome collisions. https://t.co/A3RjOkq62k

[The Ban Lab @The_Ban_Lab]

We have optimized a human in-vitro translation system (HITS) for use in #ribosome research

Our HITS:
🧪requires a minimal number of components
💵is cheap & easy to prepare
💡enables cap-dependent translation
📈is highly active

online now: https://t.co/h9pnqXkGgS
@CellRepMethods

[Chris H. Hill @chillzaa]

🥳Thrilled to share our new paper describing Balon, a bacterial ribosome hibernation factor that resembles aeRF1 family proteins. Fantastic collaboration with Karla Helena Bueno @SergeyVMelniko1 and @mariia_rybak @gagnon_lab
https://t.co/Jp9fceA4zi

[Jay Brito Querido @Jayquerido]

I am thrilled to share our new paper published in @NatureSMB (Brito Querido et al., 2024). #CryoEM structure of a human translation initiation complex reveals two independent roles for the helicase eIF4A.
#Ribosome #mRNA #Science
https://t.co/3g4mNiw88j

[Susan Shao @sshaolab]

A small molecule degrader of the translation termination factor eRF1 = a metal-dependent molecular glue on ribosomes
Learn more here! https://t.co/SVJoXkz8SP

[Jay Brito Querido @Jayquerido]

I am thrilled to share our manuscript published in @NatRevMCB.

In this Review (Brito Querido et al., 2023), we discuss the current state of knowledge on eukaryotic translation initiation and its regulation in health and disease.

[Haoxi Wu @Haoxi_xiaozzxi]

A subset of polytopic membrane proteins, such as subunits of the GABAA receptor, remains incompletely inserted when translation is terminated. We describe an essential post-translational step that completes insertion of such proteins. https://t.co/jIKZxBMpH9

[Lori Passmore @lapassmore]

We have some very exciting projects on mechanisms of DNA repair in the lab! Come join our team 🧬!

[Trends in Biochemical Sciences @TrendsBiochem]

Available now - the Review "#Cotranslational sorting and processing of newly synthesized proteins in eukaryotes" from Martin Gamerdinger and Elke @DeuerlingLab.

#NacentpolypeptideAssociatedComplex #SignalRecognitionParticle #RibosomeAssociatedComplex

https://t.co/wO8M2ONzKB

[Arjun Krishnan @compbiologist]

Excited to see fruits of a huge community effort! Thanks to @ProfMilenkovic for the leadership and the opportunity to be a part of this 🙌🏽

[Vish Chandrasekaran @vishy_chandra]

Here's a NSMB Research Briefing summarising this work, with @lapassmore
https://t.co/FZ4RkE8ozB
(Also visit Poster 99 tomorrow at the Protein synthesis and translational control EMBL conference #EMBLprotein)

[Carter Lab @Carter_Lab]

Excited to share our latest work on @biorxivpreprint! We visualised single molecules of dynein and its cofactors live in the axon. Work by @AlexFellows1 in collaboration with the @sangerinstitute (Andrew Basset, Michaela Bruntraeger and Thomas Burgold)
https://t.co/V52lE4dxfA

[Alex Fellows @AlexFellows1]

So happy to finally be able to share my post-doc work! I just want to say a massive thank you to everyone who has helped/supported me during this project.

[Markus Höpfler @MarkusHopfler]

🚨Out now!🚨 Check out how cells adjust their tubulin mRNA levels in response to excess free tubulin. A 40-year-old puzzle solved! Wonderful collaboration with @AbsmeierEva, @lapassmore & @Ivana_Gasic 🧵 1/
https://t.co/FrlnvtIlLR

[Vish Chandrasekaran @vishy_chandra]

Congratulations, Takanori

[The Ban Lab @The_Ban_Lab]

Wonderful collaboration with @FilipovskaLab reveals secrets of non-canonical translation termination in mitochondria. Structural insights and ribosome profiling explain how mtRF1 recognizes noncanonical stop codons in human mitochondria. @ScienceMagazine
https://t.co/3nR16oaE1K

[Becky Menday @BeckyMenday]

Absolutely mind blowing talk from @alanbrownhms about the beautiful structures of axonemes! I thought I had a lot of structures to build but his team’s work really puts it into perspective! @ccp_em #cryoEM