Adi

(he/him) Postdoc @ICR_London | DNA replication, chromatin & cell division | 🏳️‍🌈

Follow me on Bluesky

[Adi @wildtypecell]

I have joined Bluesky and I will be posting regularly on Bluesky, instead of X.

Follow me on Bluesky https://t.co/ipcrF2Luyh

[Adi @wildtypecell]

Excited to share our review where we propose models for how DNA secondary structures destabilise the replication fork and lead to ssDNA gaps — it’s comprehensive but genuinely a thought-provoking piece. Hope it’s useful to the community.

https://t.co/PngokVlMb7

[Robin Sebastian @rob_seb_]

Thrilled to share our latest work in @Nature! We show how cancer cells navigate DNA replication despite DNA damage, revealing new insights into genome stability. Huge thanks to my incredible collaborators! Check it out here: https://t.co/XveTox3LEb

[Emilia Hojel @EmiliaHojelP]

I'm diving into machine learning for biology! I have some coding experience but no ML background, and my first milestone is getting up to speed with #AlphaFold2. Any tips or resources on where to begin?

[Adi @wildtypecell]

"Your work demonstrates to scientists, politicians and university administrators how important it is that scientists are given the freedom to pursue promising lines of research without having to worry about their immediate practical applications"

Such an important statement

[The Nobel Prize @NobelPrize]

Barbara McClintock's discoveries on genetics were so far beyond the understanding of the time that other scientists ignored her work for more than a decade. But she trusted her evidence and persisted.

Watch the very moment she received the medicine prize in 1983.

#NobelPrize

[Science Magazine @ScienceMagazine]

A new study finds ants best humans at tests of collective intelligence.

Learn more: https://t.co/MHbFGxo1ET @NewsfromScience

[Niko McCarty. @NikoMcCarty]

I wrote up some notes on visualizing proteins in David Goodsell's cartoon-ish style using PyMOL (or ChatGPT, or other software.)

[Itai Yanai @ItaiYanai]

Only the unimaginative limit themselves to hypotheses when analyzing a new dataset. A thread on exploratory data analysis ⬇️

[Sarah Marzi @sj_marzi]

So excited that our work on predicting gene expression from histone modifications using deep learning is out in @NAR_Open today. Brilliant to work with lead author @Al_Murphy_ and collaborators Aydan Askarova, @BorisLenhard and
@n_skene 🧬⭐️🙏
https://t.co/4TEnRgbYim

[Adi @wildtypecell]

Check out our recent work uncovering an unexpected role of the replicative helicase CMG in influencing cell fate decisions in vivo! We also showed that it promotes differential expression of the highly conserved cell death gene egl-1 in cells fated to die!

[UCL Research Dept of Cell & Developmental Biology @uclcdb]

Our researchers, in a paper just published in Nature Comms, offer new insights into how different #cell
types are generated during animal #development. This could help with #autoimmunity, #cancer and #developmental abnormalities. https://t.co/tTAY6MmcHt
@ucl @UCLLifeSciences

[Adi @wildtypecell]

This work was done at @uclcdb and other collaborators in Germany!

@UCLResearch @uclbiosciences

[Adi @wildtypecell]

Check out the press release I wrote about our latest work on cell fate decisions in vivo! Our study has revealed that the highly conserved replicative helicase CMG promotes apoptotic fate & others such as neuronal or glial cell fate

#ResearchHighlights

https://t.co/Uz4Sw2PmDW

[Prof. Nikolai Slavov @slavov_n]

“Writing = thinking”

.

[Parmita Mishra @parmita]

A friend asked me to explain DNA, RNA, and epigenetics. he said that others had tried before, but it didn’t click for him.

I happen to play the piano, so I gave him a simple, albeit imperfect, analogy.

After this analogy, he finally understood! Here’s the piano analogy.

🧵

[Bleichert Lab @BleichertLab]

Our study on how the human MCM2-7 helicase is loaded onto replication origins 🧬 is now online @Nature! 🎉

Our findings reveal that unlike in yeast, human MCM loading does not require ORC6 and can occur through multiple pathways.

Read more here: https://t.co/bPT5Y4uPkR

[Molecular Cell @MolecularCell]

Online Now: Acute multi-level response to defective de novo chromatin assembly in S-phase https://t.co/X0Is63l9Nr

[Francesco Padovani @frank_pado]

SpotMAX, our software tool for analysing multi-dimensional microscopy data, is finally out! 🎉 And conveniently, I just presented it at the #I2K conference 😀
A multi-year-long effort of many great collaborators and users. But what can SpotMAX do? A small thread

[Kazuhiro Maeshima @kazu_maeshima]

Thrilled to share our new work @biorxivpreprint:
https://t.co/6unXV2pn2C
Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live cells. We reveal genome chromatin is essentially replicated from regions with greater nucleosome motions. 1/2

[Sketching Science @sketchscience]

Wonderful news! Parafilm M rules!
Very well-deserved recognition after helping so many other #NobelPrize winners achieve their breakthroughs! Congratulations @ParafilmM

[The Nobel Prize @NobelPrize]

This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans.

Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals, making it a useful model for investigating how tissues develop and mature in multicellular organisms.

Read how the 2024 medicine laureates’ investigations into C. elegans revealed an entirely new dimension to gene regulation: https://t.co/8RwUplwYQA

#NobelPrize