Yao Wei Lu

Assistant Professor of Medicine @KECKSchool_USC | Interested in the heart and blood vessels | Outdoor enthusiast | Views are my own

[Frank Conlon @fconlon]

Congrats to my PhD student Kayla Mason!!

Scientists discover a genetic mechanism that protects the developing female heart.
https://t.co/W3C5QW0qXz

Scientific article: https://t.co/5Di32Eq6W7

#DDX3X #RNA #HeartDevelopment #CongenitalHeartDisease

[Genes & Development @GenesDev]

RESEARCH PAPER: DDX3X-mediated translation of structured cardiac mRNAs is essential for female heart development
By Mason et al. and Frank Conlon
➡️ https://t.co/yluPDTaP4f

@UNC
#cardiacdevelopment #sexdifferences #Xlinked #translation

[Yao Wei Lu @yaoweilu]

@tongbinwu Congratularions, Tongbin!!

[Yao Wei Lu @yaoweilu]

@GuonHuang @NatureCVR Thank you, Guo!

[Yao Wei Lu @yaoweilu]

RNA splicing meets heart development ❤️
Excited to share our latest in @NatureCVR: PCBP1 regulates AARS2 splicing, linking RNA-binding proteins to mitochondrial biology in the developing heart. #CardioResearch #Cardiomyopathy #RNAsplicing
https://t.co/UTRzZNjQxz

[Journal of Clinical Investigation @jclinicalinvest]

The long noncoding RNA CARDINAL attenuates cardiac hypertrophy by modulating protein translation: https://t.co/20JiKCDgQW

@harvardmed
#Cardiology #Development

[Yao Wei Lu @yaoweilu]

@zhaowang4695 Congratulations, Zhao! 🍾

[Yao Wei Lu @yaoweilu]

@MasonSweatPhD Congratulations, Mason!!

[Yao Wei Lu @yaoweilu]

@peihengg_heart @Transactivator @bsabari @mikayla_eppert Congratulations!!

[Yao Wei Lu @yaoweilu]

Amazing tale of how tails are “spliced out”.

[Itai Yanai @ItaiYanai]

How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. https://t.co/0ZR8aH23PJ @BoXia7

[Yao Wei Lu @yaoweilu]

@HirofumiKiyoka1 Thank you, Hirofumi!

[Yao Wei Lu @yaoweilu]

@peihengg_heart Thank you, Peiheng!

[Jessie Huang @hjhjess]

And absolutely pumped to be embarking on this #newPI life with my other half @yaoweilu who is starting his own lab ❤️ Gooo Trojans!

[Yao Wei Lu @yaoweilu]

I’m thrilled to announce the opening of the Lu lab today at the @KECKSchool_USC. My lab will study the mechanisms of cardiovascular development and regeneration. I'm hiring at all levels; please contact me if you want to join our group.

[Yao Wei Lu @yaoweilu]

Excited to share our latest work, we found that deletion of a single allele of MRPS5 in mice results in elevated #cardiomyocyte proliferation and cardiac regeneration.

[Circulation @CircAHA]

#ICYMI: MRPS5 suppression promotes heart regeneration @yaoweilu #AHAJournals

[Yao Wei Lu @yaoweilu]

@MiaoCui_713 @Dev_Cell @Transactivator Congrats!!

[Circulation @CircAHA]

#OriginalResearch: A novel long noncoding RNA, #INKILN, promotes inflammation in #VascularSmoothMuscleCells and is induced in atherosclerosis and aortic aneurysms #AHAJournals @LarsMaeg @clintomics @yaoweilu @NestorIshimwe @barrosolab https://t.co/rI6GuXkrTm

[Hao Zhu Lab @Zhu_Lab]

Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: https://t.co/Vu1d4U3stc 1/10

[Yao Wei Lu @yaoweilu]

Proud to have contributed to this collaborative work led by Feng Gao from Jinghai Chen’s lab. Through studying the heart defects caused by deficiency of mito-ribosomal protein MRPS5, we identified KLF15 as a key target repressed by metabolite L-phenylalanine-induced MYC.

[Nature Communications @NatureComms]

Communication from the mitochondria to the nucleus is important for heart development and function <3

https://t.co/eU6xQBJOUW

[Benoit Bruneau @benoitbruneau]

well good morning all! Martin Dominguez's and colleagues' paper is out today! https://t.co/aUvJNcmiI4