🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
https://t.co/KGTUAZqHyS
Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation https://t.co/59BUNsuUYR
We are thrilled to release our manuscript titled "Human Immune Cells Epigenomic Signatures in Response to Infectious Diseases and Chemical Exposures", which was led by my colleague @h_manoj and me. https://t.co/lE5yzHdfjg
🔊 Attention computational biologists, it's time to get ready and start preparing your #RECOMB2024 submission(s)!
🗓️ Abstract registration: October 16, 2023
🗓️ Full paper submission: October 20, 2023
Follow @RECOMBconf. See "Call for Papers" for details: https://t.co/qdZomutyI7
Multiplicity of enhancers interacting with the Ets1 gene in T cells is essential to control the precise dosage of Ets1 in response to cytokine cues, and the failure to do so can lead to allergic diseases @golnaz_v#HenaoMejia@ImmunityCP
https://t.co/XF5bEqenGy
I feel immense pride to share the results of an exceptional collaboration between Vahedi @vahedilab and Henao-Mejia laboratories in @ImmunityCP today.
https://t.co/znAdLrEaOc
We discovered that the hyperconnectivity of the Ets1 locus controls the precise expression level of this protein which is required for optimal CD4 T cell differentiation.
The @vahedilab and Henao-Mejia laboratories present their latest preprint titled "A multi-enhancer hub at the Ets1 locus controls T cell differentiation and allergic
inflammation through 3D genome topology" https://t.co/Ek26gb9Ju5
So far, most DNA-loop-extrusion data were taken on naked DNA. But what happens on chromatin in cells where DNA is loaded with many proteins? Will SMC proteins (that are fast but weak motor proteins) get blocked? Or find a way to translocate the roadblock into the extruded loop?
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Phys. Rev. E 104, 044401 (2021) - Heterogeneity is not always a source of noise: Stochastic gene expression in regulatory heterozygote https://t.co/XB4flMbqfG
“Although TADs and chromatin loops as distinguishing features of Hi-C maps were described in pioneering studies, structures appearing as lines, flames or stripes attracted attention most recently”
Researchers @ysora90@golnaz_v show architectural stripes are enriched at transcriptionally active and accessible genomic regions using their stripe detection tool #Stripenn#stripe#3Dgenome#4DN
https://t.co/opovRusmIS
#Epigenomics#Bioinformatics: scientists have devised a computer vision algorithm to detect and quantitate architectural stripes from chromatin conformation data. The algorithm could help to identify key genes involved in cell identity and function - https://t.co/JaT8Zaq49b
We are thrilled to share the publication of Stripenn, a computational technique to detect architectural stripes from chromatin conformation data https://t.co/2CyWrYsT8c
Congrats to the one and only @ysora90 for spearheading this project
Congratulations to this year's @PennMedicine Awards of Excellence winners!🎉 Read the full list of awardees-recognized for their exemplary contributions to patient care, mentoring, research & teaching- here➡️ https://t.co/ZW1l3cAJcc Check back next week as we profile each winner