Zach McLean

Postdoc biologist from Aotearoa New Zealand

[Zach McLean @zazzamc]

@strnr I've also seen one where the audience can upvote questions to help prioritize, and you could submit the question anonymously!

[Zach McLean @zazzamc]

@DonaldH3498 @OnlyInBOS Owning a car is insanely expensive, so making a society where people have to depend on a car to get around is literally making poor people less free.

[HDF @hdfcures]

HDF-supported researchers publish surprising, and serendipitous, findings about huntingtin lowering drugs!
Read it here https://t.co/ekOMu5Cz6r #cureHD @HDYOFeed @HDSA @HDBuzzFeed @AmericanBrainCo

[Zach McLean @zazzamc]

@MikeConnollyMA Also not pictured is the shoddy job on the new bike lanes to get to this station. Need a BMX bike to traverse the huge bumps at the start of one of the protected lanes!

[Zach McLean @zazzamc]

@VDion_and_Lab Amazing work, congratulations Vincent!

[Zach McLean @zazzamc]

@RepPressley @RepCori @RepRashida @RepAndreCarson @repdeliaramirez @RepSummerLee Glad you're my congressperson ♥️

[Zach McLean @zazzamc]

@parismarx In my time in the US people are often romanticizing NZ as some sort of liberal paradise and wonder why I would move. Decades of depressing neoliberalism with no hope of improvement, a celebration of ignorance , low wages and high cost of living. Makes going back difficult 😭

[Zach McLean @zazzamc]

@ATinyGreenCell My experience with this technique is that when you get nice bands like that it usually works, especially with so many cycles. High chance of success! I also never clean up the PCR/dpnI reaction

[Zach McLean @zazzamc]

By lowering PMS1, the splice modulators reduced the rate of CAG repeat expansion, which is the first step of disease pathogenesis, making splice modulation of PMS1 a potential strategy for delaying HD onset.

[Zach McLean @zazzamc]

I am excited to share our interesting new story for #Huntingtonsdisease therapeutics! Splice modulating drugs were/are in clinal trials for lowering HTT. We show that at high concentrations they coincidentally also target another known genetic modifier of HD onset, PMS1.

[bioRxiv @biorxivpreprint]

PMS1 as a target for splice modulation to prevent somatic CAG repeat expansion in Huntington's disease https://t.co/i1rf7LZj2p #bioRxiv

[Zach McLean @zazzamc]

@gmdoherty A vote to unionize doesn't mean a vote to strike, that's anti union propaganda

[Zach McLean @zazzamc]

@MikeConnollyMA 🎉🎉🎉 does anyone know how to find all the path entryways?