Bing-Rui Zhou

Scientist at National Cancer Institute, NIH. study #Chromatin, interested in #cryoEM, all opinions are my own.

[Bing-Rui Zhou @zhoubr]

Delighted to share our highly collaborative study on the native ALB N1 nucleosome recognition and chromatin opening by the prototypes of pioneer factors, FOXA1 and GATA4, which is now online @MolecularCell https://t.co/rmhvLLJwmu

[Bing-Rui Zhou @zhoubr]

@AlexKellyLab @ScienceAdvances @TakashiAkeraLab Congratulations! Hindol and all the authors

[OpenProtein.AI @openprotein]

Design protein binders in minutes, not months.

New on https://t.co/NGI2kaXi7Z
→ Improved protein design GUI & refolding metrics for candidate filtering
→ New structure design models (RFdiffusion, BoltzGen)

Nanobody + miniprotein design walkthroughs now live! Links in thread

[Shiv Grewal @grewalsh]

Stress controls epigenetic inheritance!

A histone ubiquitylation-based regulatory hub links stress/environmental signaling to heterochromatin self-propagation and epigenetic inheritance-reshaping how we think about development, drug resistance and cancer👉https://t.co/Wf8y1HjHEX

[Bing-Rui Zhou @zhoubr]

@grewalsh Huge congratulations to @grewalsh lab and all the authors! Amazing story!

[Brian Hie @BrianHie]

Today, we report Germinal, a method for efficient de novo antibody design, with @santimillef and @SynBioGaoLab.

Germinal achieves success rates of 4-22% across diverse epitopes.

We make the work fully open, without doing lame things like posting a preprint without methods. 🧵

[Bing-Rui Zhou @zhoubr]

@FadiniAli @mhli41 Congratulations, Great work! Does ROCKET also work for nucleic acid or protein/nucleic acid complexes?

[The Nobel Prize @NobelPrize]

Work that once took years now takes just a few minutes thanks to this year’s chemistry laureates.

2024 #NobelPrize laureates Demis Hassabis and John Jumper have used their AI model AlphaFold2 to calculate the structure of all human proteins. They also predicted the structure of virtually all the 200 million proteins that researchers have so far discovered when mapping Earth’s organisms.

Google DeepMind has also made the code for AlphaFold2 publicly available, and anyone can access it. The AI model has become a gold mine for researchers. By October 2024, AlphaFold2 had been used by more than two million people from 190 countries.

The picture shows a few of the many examples of how AlphaFold2 helps researchers.

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

[Shiv Grewal @grewalsh]

🎉 Exciting Announcement! 🎉

“Histone Modifications and Chromatin Structure Symposium”

🗓️ Dates: October 17-18, 2024
📍 Location: National Institutes of Health, Bethesda, Maryland

The NCI Center of Excellence in Chromosome Biology is delighted to invite you to our upcoming symposium. This symposium honors the legacies of Dr. C. David Allis and Dr. Gary Felsenfeld, pioneers in the study of chromatin and gene expression. Presentations from 25 renowned scientists. For more details and to register, visit: https://t.co/U2k3eG0aDQ

[Bing-Rui Zhou @zhoubr]

@chongyi_chen Big congrats to Chongyi, Qian, Linying and all the authors!

[Bing-Rui Zhou @zhoubr]

@holla_sahana @MolecularCell Thank you, Sahana!

[Bing-Rui Zhou @zhoubr]

Delighted to share our highly collaborative study on the native ALB N1 nucleosome recognition and chromatin opening by the prototypes of pioneer factors, FOXA1 and GATA4, which is now online @MolecularCell https://t.co/rmhvLLJwmu

[Bing-Rui Zhou @zhoubr]

@Manish_nih @MolecularCell Thank you, Manish!

[Bing-Rui Zhou @zhoubr]

@dpmelters Thank you, Dan!

[Bing-Rui Zhou @zhoubr]

Here is the author copy if you are behind the paywall:
https://t.co/RhF1q0TxCP

[Molecular Cell @MolecularCell]

Online Now: Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4 https://t.co/TJCmsFGEmF

[Bing-Rui Zhou @zhoubr]

@cojocarulab Thank you, Vlad!

[Bing-Rui Zhou @zhoubr]

@NCIYaminiDalal @NCIResearchCtr @tamar_schlick @pioneerfactors Thank you, Yamini!

[Bing-Rui Zhou @zhoubr]

@grewalsh Thank you Shiv!

[Bing-Rui Zhou @zhoubr]

Curious about how FOXA1 and GATA4 are capable of competing with H1 and opening the chromatin? get some hints from this interesting movie and read more in our publication https://t.co/RhF1q0TxCP

[Bing-Rui Zhou @zhoubr]

A shoutout to our collaborators for their invaluable contribution to this work: gene editing in vivo study by Wang Lab @QianbenWang, in silico analysis by Landsman lab @DavidLandsman and Schlick lab @tamar_schlick, and of course great insights by Ken Zaret @pioneerfactors