P-Y McLaughlin

Radiation Oncologist in the Radiation Medicine Program @OttawaHospital @uOttawaRad

[P-Y McLaughlin @AcadianRO]

Long-term disease-free survival and health-related quality of life results of HDR brachytherapy as monotherapy https://t.co/OLs6nBCKxs
Long term outcomes for prospective trial of HDR monotherapy - very reassuring outcomes, despite most patients not being MR-staged at the time

[Memorial Sloan Kettering Cancer Center @MSKCancerCenter]

Today at #ASCO26: MSK radiation oncologist Dr. Nancy Lee (@imrtlee) shared long-term results showing that many patients with HPV-positive #oropharyngeal cancer were able to receive lower-dose radiation while maintaining durable outcomes and experiencing fewer side effects.

[P-Y McLaughlin @AcadianRO]

ESTRO statement on the Proteus trial. More deaths in the Apa arm in high risk patients who mostly don’t die from prostate cancer 5-10 years out makes one take a step back https://t.co/LYUEGtIE36

[PDBrown @PDBrownOnc]

🚨🚨 ASCO 2026 Final Results Randomized trial resected brain met Brachytherapy vs Post-Op SRS🚨
- Incredible Surg Bed Control with Brachy (↑↑OS as well)
- Surg bed recurrence 12% SRS vs 1% GammaTile

[Chad Tang, MD @ChadTangMD]

Calling all Brachytherapists, 15 year results from ascende RT presented by #scotttyldesley showing continued biochemical PFS, no OS benefit but benefit in prostate cancer specific deaths. @AmericanBrachy @ASTRO_org

[P-Y McLaughlin @AcadianRO]

@stats_feed A variation/rip-off of @JoeListComedy ‘s bit?

[Luiza Giuliani Schmitt, MD @giuliani_luiza]

Excited to share our latest work in Advances in Radiation Oncology! 🚀

We compared outcomes of 5-fraction adaptive MRI-guided RT for newly diagnosed glioblastoma vs. 15- & 30-fraction regimens using propensity score matching.

📄https://t.co/BBFJjqLdMS

[Dr Amol Akhade @SuyogCancer]

What if this was a drug ?🙂

🆕 NEJM | June 2025
🎯 CHALLENGE Trial: Structured exercise after adjuvant chemo in colon cancer
📦 RCT | n=889 | Median FU: 7.9 yrs
🟠 3-yr structured aerobic program vs health ed alone
📈 Primary Endpoint: Disease-Free Survival (DFS)
🔹 HR 0.72 (95% CI: 0.55–0.94), p=0.02
🔹 5-yr DFS: 80.3% vs 73.9% (+6.4%)
🟨 Overall Survival (OS)
🔸 HR 0.63 (95% CI: 0.43–0.94)
🔸 8-yr OS: 90.3% vs 83.2% (+7.1%)
🧠 Other highlights:
🔻 ↓ Liver recurrence: 3.6% vs 6.5%
🔻 ↓ New primary cancers: 5.2% vs 9.7%
🔻 Improved cardiorespiratory fitness, QoL, 6-min walk
⚠️ AEs: ↑ MSK issues (18.5% vs 11.5%), mostly mild
No major safety concerns
🤔 What if this was a drug?
📢 “Breakthrough”
💰 $120K/year
📄 Fast-track approval
Instead, it’s just structured EXERCISE.
💡 Prescribe it like we would any other adjuvant therapy.
Congratulations to Authors and Dr Chris Booth 👏
#CHALLENGEtrial #ASCO25 @csoncol @oncology_bg @ASCO #ASCO25 @OncoAlert

[NEJM @NEJM]

Presented at #ASCO25:

A 3-year structured exercise program after adjuvant chemotherapy for colon cancer improved disease-free and overall survival, physical functioning, and fitness, as compared with health education alone. Full CHALLENGE phase 3 trial results: https://t.co/j3kWJDjuVz

@ASCO

[P-Y McLaughlin @AcadianRO]

@drdrew Gleason 9 prostate cancer is by definition rapidly progressive. It can missed on screening (often normal or only slightly elevated PSA; nodule/symptoms appearing in months). I see this in practice 1-2x/month as a radiation oncologist. Way to fall into the political spin.

[P-Y McLaughlin @AcadianRO]

@iamcoriarnold If only we this was combined with meaningful US deficit and debt reduction, but this won’t happen . A few trillion will be added to the debt by this administration if plan goes through with tax cuts, etc. Also, 2026 elections will go badly for the Rs and tariffs will be reversed

[Daniel Koffler, MD @dmkoffler]

Relatedly, the ceaseless pressure in oncology to omit adjuvant RT for breast cancer in favor of years of toxic endocrine therapy is as much a betrayal of women’s health as the persistence of Halsted mastectomies long after it was clear they are harmful

[Martin King @MtkingMD]

Our article on long-term outcomes of the 44/20 and 20/0 randomized trials involving prostate brachytherapy has been published in Practical Radiation Oncology!

https://t.co/MiHPYUNp6p
@AmericanBrachy

[P-Y McLaughlin @AcadianRO]

@NiuSanford The inpatient RO ward is a dwindling phenomenon, most places don't have it anymore; in Ottawa since last year, RO residents will admit patients but then hospitalists take over the care. Confirming Costco fries as country wide though :D

[P-Y McLaughlin @AcadianRO]

@HewittJSB @hyperionrecords @AppleMusic Thank you Ms. Hewitt, and just to be clear that is a @AppleClassical feature. Really enjoyed your concert at the NAC last winter!

[Alastair McAlpine, MD @AlastairMcA30]

A vaccine has essentially eliminated a dreadful form of cancer.
Extraordinary.

[Niema Razavian, MD @RadOncDoc_Niema]

When the #radonc contours only the PTV

[P-Y McLaughlin @AcadianRO]

@KylePorterCBS Rich beem cool dude too

[P-Y McLaughlin @AcadianRO]

Je vous recommande cet article de La Presse : Des médecins implorent le ministre Dubé d’agir https://t.co/fGmqM4EPsL