Ariax Bio

World-class AI-powered protein design tools like BindCraft and BoltzGen, no-code UI, and instant GPUs—30% cheaper than AWS. Just pay for compute.

[Ariax Bio @AriaxBio]

Through Oct 31 (Pacific), save up to 40% on CLI GPU compute:

H100: $4/GPU-hour
A100 80GB: $2.50/GPU-hour

Existing credits apply.

https://t.co/rhqVxYmotk

[Ariax Bio @AriaxBio]

Ariax goes agentic. The best protein designer is already on your computer.

Give Codex, Claude Code, or your preferred agent hosted protein-design tools and engine-specific skills with the Ariax CLI.

https://t.co/Mg6iTYhGSZ

[Ariax Bio @AriaxBio]

Run BindCraft2 on Ariax without installing software or managing GPUs. Configure your experiment, launch a campaign, and review structures and results in your browser.

Free for academic AND commercial use. No separate commercial license. Pay only for compute.

[Ariax Bio @AriaxBio]

BindCraft2 from the @MartinPacesa lab is here and available now on Ariax!

We called BindCraft a “DeepSeek moment” in protein design. BC2 builds on that proven foundation with major speed improvements and a much broader range of therapeutic formats.

https://t.co/DfblZW5jsL

[Ariax Bio @AriaxBio]

Miniproteins, Fab, scFv variable domains, VHH, ankyrin-repeat proteins, and linear/cyclic peptides.

Add multi-target design, off-target avoidance, and more biological control. All built around BindCraft’s AF2-guided design and ProteinMPNN workflow.

https://t.co/6A9tTrUf9a

[Ariax Bio @AriaxBio]

Design nanobodies, antibodies, and miniproteins with ESMFold2, the latest state-of-the-art model from the ESM team.

ESMFold2-pipeline is now live on Ariax Bio, the only hosted platform for the complete design workflow.

Read our announcement:
https://t.co/yXFhUnNccr

[Brian Naughton @btnaughton]

Thanks to @NikoMcCarty and the Asimov team for helping me get this out!

Hopefully an interesting view into where we are with AI antibody design today. Featuring @boltz_bio BindCraft @ai4s_protenix @AriaxBio @modal @tamarindbio @diffuse_bio @try_litefold @chaidiscovery @nablabio

[Adaptyv Bio @adaptyvbio]

What happened in the Nipah Protein Design Competition so far?
Plus: Prediction markets for protein design

TLDR:

• We hosted our third installment of the Protein Design Competition on @proteinbase, this time challenging participants to design a binder against the Nipah virus glycoprotein.

• The response was incredible: Over 10’000 designs were submitted, over 5 times the number of designs in the past 2 competitions combined, with more than 650 total participants.

• We’re currently testing all 1’200 selected designs, but, in the meantime, we’re taking a brief detour into what happened during the competition. Which model was the fan favorite? What did the top-ranking designs look like? And how can we select a better ranking metric for future competitions?

• Plus, we opened a prediction market on Manifold for this competition so you can bet on hit rates, best performing models, and more

[Ariax Bio @AriaxBio]

Curious how to run BoltzGen?

Our new tutorial walks through the complete workflow using our Adaptyv Nipah Competition submission as a real-world example. Target prep, hotspot selection, and launching parallel VHH/miniprotein campaigns.

Full tutorial: https://t.co/6gjRzBDkyu

[Ariax Bio @AriaxBio]

For alpha helical peptides, BindCraft is the SOTA model to beat. See our tutorial and commentary from BindCraft creator Martin Pacesa here:

https://t.co/DU2uKVtLd1

[Kyle Tretina, Ph.D. @AllThingsApx]

BindCraft is generating high-affinity peptides from structure alone 🧬

MDM2: 47% hit rate (7/15 tested) with nM affinity. For WDR5, structural predictions were so precise they enabled "one-shot" stapling for a 6× potency boost (Kd 39nM).

No phage display. No alanine scanning.

GenAI is accelerating rational chemical design with less wet-lab screening.

[Ariax Bio @AriaxBio]

New GPUs on Ariax: Nvidia B300 + RTX 6000 Pro now live.

B300 delivers a major performance jump for large/time-critical protein design campaigns. RTX 6000 Pro brings high VRAM for phenomenal value.

BindCraft already runs on B300; BoltzGen support soon.

https://t.co/1uurl0T2aU

[Ariax Bio @AriaxBio]

Open source strikes back!

BoltzGen delivers Chai-2 level antibody design performance under an MIT license. Design nanobodies (VHH), cyclic-peptides, helicons, and miniproteins with an all-atom framework.

Run it now without limits on Ariax.

https://t.co/Z1wfWbToPt

[GAMA Miguel Angel 🐦‍⬛🔑 @miangoar]

1/2 We're now living the dream of (almost) fully programmable protein design. Learning about BindCraft is now essential 🧐
https://t.co/LnHAZmhsM0

Code to complex: AI-driven de novo binder design
https://t.co/04JQRc9PkM

Thanks to @MartinPacesa, Lennart N., and @AriaxBio :)

[Martin Pacesa @MartinPacesa]

We were so excited to meet and discuss with the protein community in Mexico, it was a great experience and we saw many great BindCraft designs generated in just one day session! Thanks to @aaronmring’s amazing @AriaxBio platform that made running it easier with so many teams

[Ariax Bio @AriaxBio]

We also shipped project cloning: reuse any job's settings as a template for variations. Test different hotspots, adjust filters, or simply get more designs without re-entering everything. Both features are live now.

[Ariax Bio @AriaxBio]

Waiting days for BindCraft results? Not anymore.

Turbo Mode splits your job across multiple GPUs for up to 8x faster completion. A typical 48-hour campaign now finishes in 6 hours: https://t.co/SYyzIAwVwp

[Ariax Bio @AriaxBio]

@BioExplorr We use NGL Viewer (https://t.co/kaxECAI8tn) extensively on our platform, in the prep inputs feature and elsewhere. It's robust, lightweight, and easy to use.

[Ariax Bio @AriaxBio]

Preparing PDB files for protein design usually means wrestling with PyMOL or ChimeraX. We're making it easier.

Watch us use our new Prep Inputs feature to go from PDB fetch → structure trimming → hotspot selection → launching a design job in a leisurely 75 seconds.

[Ariax Bio @AriaxBio]

@MartinPacesa Thanks Martin! BindCraft has been transformative for the field... it deserved a GUI!

[Ariax Bio @AriaxBio]

👀

[alex rubinsteyn @iskander]

I love these and also...they're ludicrous.

(BindCraft designed miniprotein for crystallizable core of NUTM1)

[Ariax Bio @AriaxBio]

Full tutorial:
https://t.co/e59qfIeSRM

[Ariax Bio @AriaxBio]

Prep Inputs handles the tedious parts:

Load structures from RCSB or local files (PDB or CIF)
Trim chains & residues visually
Auto-detect binding interfaces
Export BindCraft-ready PDBs or start the job at Ariax

Free to use and everything runs locally in your browser.