Salman Banani

Assistant Professor @UChicago | Previously @WhiteheadInst @BrighamWomens @UTSWNews. Condensate biology and disease.

[David Sinclair @davidasinclair]

Finally! Been waiting all month

[Surya Nagaraja @snaga13]

Excited to share my postdoc work with @JD_Buenrostro now out in @Nature!
"Epigenetic memory of colitis promotes tumour growth"
https://t.co/6703aeQlLG

We wanted to understand how transient inflammation can create a long-lived increase in cancer risk, even after full recovery 🧵

[Raghu Chivukula, MD PhD 🫁🧬🧠 @chivukula_raghu]

Why do some genetic mutations devastate specific tissues while sparing others?

We explore this question in GGC repeat disorders, revealing a mechanism linking protein aggregation to tRNA splicing failure in the brain.

🧵 on our new paper in Science:
🔗 https://t.co/a9rB53kRoS

[Denes Hnisz @dhnisz]

On its 65 year anniversary, the story of the incredibly brave Frances Oldham Kelsey. A role model for competence, character and courage.
https://t.co/xJwqZdVsy3

[Information Theory of Aging @infotheoryaging]

ITOA is catching on

[Ben Sabari @bsabari]

I am excited to share the latest paper from my lab where we leverage the selection bias of condensate-promoting oncofusions to uncover molecular rules governing condensate specificity and function. https://t.co/AQlErs3lni.

[Dana-Farber News @DanaFarberNews]

Riaz Gillani, MD, and @RyanLCollins13 in @VanAllenLab @DanaFarber report in @ScienceMagazine that rare germline genetic abnormalities increase the risk of pediatric solid cancers, findings that could help improve treatments and screening.

➡️ https://t.co/mBdXjomfSu

[Ani Chattaraj @AniChattaraj]

What drives two liquid droplets to merge? The usual answer is surface tension. This picture is slightly different for biological condensates. To know more, please check out our recent @BiophysJ paper:
https://t.co/tgLaRZGqm8 @HarvardCCB @ShakhnovichLab

[Whitehead Institute @WhiteheadInst]

Many chronic diseases have a common denominator that could be driving their dysfunction: reduced protein mobility, which in turn reduces protein function. A new paper from @youngricka's lab describes this pervasive mobility defect: https://t.co/2BxETPuCra

[Ben Sabari @bsabari]

I am excited to share our review, published online today @NatRevMCB. Pilong Li, Gaofeng Pei, @Heankel_, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1).

https://t.co/k5F3HElanv

[Pradeep Natarajan @npradeep96]

Pre-print alert! With experimental collaborators at the Young lab (MIT), we investigate how (i)active rRNA transcription maintains the size, spacing, and number of nucleolar fibrillar centers, (ii) the consequence of this arrangement on rRNA processing.
https://t.co/Pm0FMqPp5G

[UT Southwestern Medical Center @UTSWMedCenter]

#UTSW biochemist Zhijian "James" Chen, Ph.D., wins the Albert Lasker Basic Medical Research Award, sometimes called “America’s Nobel,” for his discovery of the cGAS enzyme, which senses invading pathogens and triggers immune response. https://t.co/q7NWqorgja @LaskerFDN

[Ben Sabari @bsabari]

Excited to share that our paper https://t.co/hOsRI6TOxY got the cover of the new issue of @MolecularCell. Extra cool that this is a photograph taken by the first author @Nancybrillet, a super-star research assistant and post-bacc who just started grad school @UTSWGradSchool

[Ben Sabari @bsabari]

Checkout the latest work from the lab online today in @MolecularCell where we find that distinct sequence features encoded in IDRs are responsible for targeting proteins to specific condensates. This work was led by @Nancybrillet @Prashan10011102 and @TvReshma .

[Prashant Bhat @_prashantbhat]

A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in @Nature for nuclear speckles and mRNA splicing. Check out this thread!

https://t.co/DoXSB7SINt

[David Kuster @RNADavid]

Amazing review with very insightful analogies!
Highly recommended!
By @JAM_Bard and @dallandrummond.

[Ben Sabari @bsabari]

Excited to share a new collaborative paper from my lab and the @transactivators lab where we find that condensate formation of the cell type specific coactivator Myocardin drives gene activation during cardiovascular differentiation.

https://t.co/ZYKNWknHb4

[Peiheng Gan @peihengg_heart]

Excited to share my third piece of postdoc work from the @Transactivator lab! This is a collaborative work with @bsabari @mikayla_eppert. We show that coactivator condensates regulate cell lineage specification. https://t.co/m7bYdBiMYs

[Whitehead Institute @WhiteheadInst]

An 11th grade student from Westford MA asks: what are condensates? Thank you postdoc Alessandra Dall'Agnese for answering their question!

Our latest #AskaScientist video is published on BioNook, Whitehead Institute's online biology resource: https://t.co/ZnWQIA8qSm