@BarbraStreisand Cheers to the Democrats for showcasing a commitment to integrity by refusing to blindly support the wrong candidate!
Btw, I loved your book @BarbraStreisand!
I'm not a person who has idols, but Daniel Kahneman came about as close as it gets for me. It is not an exaggeration to say that he revolutionized our understanding of the mind.
Among many other concepts, Kahneman and his collaborators came up with the ideas of:
โข anchoring (where an irrelevant number can influence our judgments)
โข prospect theory (a theory of how we make judgments when there is uncertainty that incorporates a number of biases)
โข the focusing illusion (where we overemphasize the importance of whatever factor we happen to be focused on at that moment)
โข the peak-end rule (where our memories of an event tend to emphasize the peak moment of greatest intensity and how the event ended)
โข the planning fallacy (the common bias where people underestimate the time and cost of large projects)
โข the availability heuristic (where we evaluate how frequent, likely, or important an event is based on how easily we can recall examples of it to memory)
โข the representativeness heuristic (where we evaluate how likely something is to be something else based on how similar it is to a prototype or stereotype rather than incorporating all the information we have, such as base rate information)
I feel grateful to have had the chance to spend a little bit of time with him. He was as wonderful in person as he was in his articles. I once even thought I found an error in one of his papers, and he was so nice about it when I pointed it out. It turns out I misinterpreted what method he used, and the paper was flawless!
The world has suffered a great loss today.
Critical thinking isn't the same a being smart. It isn't about strategy or creative solutions. It's about assessing information quality. Here's how #genAI can help...and hinder. https://t.co/20C6Dv6nIp
How should scientists conducting and publishing studies involving sex differences think about their use and clarity of concepts of female versus women or male versus men?
Imagine you lived in a universe where whatever you give your attention to gets drawn to you. So if you pay attention to cute dogs on the street, soon you'll be followed all the time by cute dogs. And if you pay attention to the angry guy muttering to himself, soon there will be angry mutterers all around you. This is similar to what new age spiritualism calls the Law of Attraction ("you attract into your life what you focus on").
This is not how the real universe works. But you know what actually does work this way? Social media. Let's call it the law of Social Media Manifestation: you manifest what you pay attention to.
On Facebook, cute animals follow me around because I like cute animal photos. On Twitter, I don't hear many angry guys muttering because I don't click on angry guy mutterings. I do, however, hear many interesting ideas because I click on and like them.
If your social media is hell, don't forget the law of Social Media Manifestation: you manifest what you pay attention to. If you want your social media to be full of interesting ideas and not brimming with angry guy mutterings, click on the former, not the latter.
If the real world worked this way, we might think it would be a paradise (all we have to do is focus on good things, and then good things will be all around us). But what social media teaches us is that if the real world worked this way, many of us would end up in a nightmare.
Fortunately, with social media, it's a nightmare that's pretty easy to wake up from. But it requires clicking and liking based on what your higher self wants you to see rather than what your lower self feels a compulsion to see.
๐ด๐๐๐๐ ๐๐๐๐๐๐๐๐๐ ๐๐๐๐ ๐๐๐๐๐ ๐ญ๐ก๐๐ญ ๐ข๐ฌ ๐ ๐จ๐ข๐ง๐ ๐ฎ๐ง๐ง๐จ๐ญ๐ข๐๐๐!
๐๐ก๐ข๐ฌ ๐๐ซ๐ญ๐ข๐๐ฅ๐ ๐ฌ๐ก๐จ๐ฐ๐ฌ ๐ ๐๐จ๐ซ๐ซ๐๐ฅ๐๐ญ๐ข๐จ๐ง ๐๐๐ญ๐ฐ๐๐๐ง ๐ข๐ง๐๐ซ๐๐๐ฌ๐๐ ๐๐๐ ๐ ๐๐๐ฅ๐ฅ ๐ฅ๐๐ฏ๐๐ฅ๐ฌ ๐๐ง๐ ๐๐๐ญ๐ข๐ ๐ฎ๐ ๐ข๐ง ๐ฉ๐๐ญ๐ข๐๐ง๐ญ๐ฌ ๐ฐ๐ข๐ญ๐ก ๐๐จ๐ง๐ ๐๐๐๐๐. ๐https://t.co/H413t5ptI9
๐๐ก๐ฒ ๐ข๐ฌ ๐ญ๐ก๐ข๐ฌ ๐ซ๐๐ฅ๐๐ญ๐ข๐จ๐ง๐ฌ๐ก๐ข๐ฉ ๐ข๐ฆ๐ฉ๐จ๐ซ๐ญ๐๐ง๐ญ?
1๏ธโฃ Because it shows an increase in CD4 T cells being ๐ข๐ง๐๐๐๐๐๐ญ๐ข๐ฏ๐ in clearing the infection.
2๏ธโฃ If we add these results with those of the other recently published article ๐ (https://t.co/ff9UmqCHXk ), it also explains that although IFN-ฮณ levels increase chronically, it is incapable in the elimination of SARs-CoV-2 reservoirs in macrophages of different tissues due to the immunosuppressive environment they generate by releasing IL-10. ๐๐ฌ ๐ข๐ง ๐ญ๐ก๐ ๐๐๐ฌ๐ ๐จ๐ ๐๐๐, B cells with latency of this virus generate reservoirs of cells that release IL-10 together with other factors that prevent T cells from eliminating them. In other words, there are continuous reservoirs that cannot be eliminated by this evasion microenvironment but continuously release viral material outside to which T cells and innate immunity respond.
3๏ธโฃ This eventually leads to ๐ข๐ฆ๐ฆ๐ฎ๐ง๐ "๐๐ฑ๐ก๐๐ฎ๐ฌ๐ญ๐ข๐จ๐ง" ๐จ๐ ๐ ๐๐๐ฅ๐ฅ๐ฌ as they are continually responding to viral antigens from viral reservoirs. In other words, they stop responding effectively.
4๏ธโฃ It also explains the increase in ๐๐ฎ๐ญ๐จ๐ข๐ฆ๐ฆ๐ฎ๐ง๐ ๐๐ข๐ฌ๐๐๐ฌ๐๐ฌ in Long COVID patients as an increase in CD4 T levels in response to chronic exposures to viral antigens in various tissues can lead to an increase in autoimmune response. It is common to have autoantibodies during viral infections that disappear after clearance, but if this becomes chronic autoimmunity would develop.
5๏ธโฃ ๐๐จ๐ฎ ๐ฆ๐๐ฒ ๐ฐ๐จ๐ง๐๐๐ซ ๐ก๐จ๐ฐ ๐ข๐ ๐๐๐ ๐ ๐๐๐ฅ๐ฅ๐ฌ ๐ข๐ง๐๐ซ๐๐๐ฌ๐ ๐ญ๐ก๐๐ซ๐ ๐๐ซ๐ ๐ซ๐๐๐๐ญ๐ข๐ฏ๐๐ญ๐ข๐จ๐ง๐ฌ ๐จ๐ ๐๐ฉ๐ฌ๐ญ๐๐ข๐ง-๐๐๐ซ๐ซ ๐ฏ๐ข๐ซ๐ฎ๐ฌ ๐ข๐ง ๐ญ๐ก๐๐ฌ๐ ๐ฉ๐๐ญ๐ข๐๐ง๐ญ๐ฌ? Because EBV is a very intelligent virus, since it uses the increase of IFN-ฮณ that appears during other infections/inflammation to infect more cells, since IFN-ฮณ increases the expression of MHC-II, and this protein is where EBV infects. In addition, the latent reservoirs of EBV (ectopic lymphoid aggregates) take advantage of the increase in antigen presentations to move from latent to lytic phase, increasing the release of virions. And if we add that these cells are "exhausted" they cannot effectively control latent viruses either.
6๏ธโฃ ๐๐ง๐ ๐ฐ๐ก๐๐ญ ๐๐จ๐๐ฌ ๐ข๐ง๐๐ซ๐๐๐ฌ๐๐ ๐๐๐๐ ๐ก๐๐ฏ๐ ๐ญ๐จ ๐๐จ ๐ฐ๐ข๐ญ๐ก ๐๐๐ญ๐ข๐ ๐ฎ๐? An increase in the activation of these cells leads to an increase in their metabolism and an increase in the release of proinflammatory cytokines that result in ongoing oxidative stress. In addition, there is a continuous response of innate immunity because adaptive immunity (CD4 and CD8 T cells) cannot control the infection, thus further increasing oxidative stress. This oxidative stress is responsible for most of the symptoms. For example, if it increases in the CNS, it leads to neuroinflammation and fatigue.
7๏ธโฃ ๐๐ง๐ ๐ฐ๐ก๐๐ญ ๐ซ๐๐ฅ๐๐ญ๐ข๐จ๐ง๐ฌ๐ก๐ข๐ฉ ๐ฐ๐จ๐ฎ๐ฅ๐ ๐ญ๐ก๐ข๐ฌ ๐ข๐ง๐๐ซ๐๐๐ฌ๐ ๐ข๐ง ๐๐๐๐ ๐ก๐๐ฏ๐ ๐ฐ๐ข๐ญ๐ก ๐ก๐ฒ๐ฉ๐จ๐๐จ๐ซ๐ญ๐ข๐ฌ๐จ๐ฅ๐ข๐ฌ๐ฆ? Well, a direct relationship. The greater the TCD4 response and innate immunity, the greater the inflammation and the greater the cortisol consumption. Moreover, chronic inflammation can also inhibit ACTH production and thus cortisol production. For this reason, in the short term, some patients with hypocortisolism improve with corticosteroids, but in the long term they worsen because infection increases due to their immunosuppressive effect.
All this follows the same line of ๐จ๐ฎ๐ซ ๐ฉ๐๐ญ๐ก๐จ๐ฉ๐ก๐ฒ๐ฌ๐ข๐จ๐ฅ๐จ๐ ๐ข๐๐๐ฅ ๐ฆ๐จ๐๐๐ฅ of the disease that links the development of an acquired immunodeficiency with the symptomatological consequences in both Long COVID and Myalgic Encephalomyelitis diseases. Link to our model: https://t.co/hdc9KNiyiC
๐ Share it with other patients so they can understand their disease - ๐ค๐ง๐จ๐ฐ๐ฅ๐๐๐ ๐ ๐ข๐ฌ ๐ฉ๐จ๐ฐ๐๐ซ! ๐
#LongCOVID #MECFS #MyalgicEncephalomyelitis #Autoimmune #lupus #RheumatoidArthritis #MultipleSclerosis #Hashimotos #Sjogrens #CrohnsDisease #UlcerativeColitis #CeliacDisease #Health #Research #News #microE2324 #Medicine #ChronicDiseases #SARSCOV2 #COVID #LongHaulers #MCAS #ME #MyE #CFS
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