Becki Saltzman

Idea trafficker. Curiosity Seeker. Question asker. Brown drink drinker. Lover of the wise and hilarious. #AppliedCuriosity

[Becki Saltzman @BeckiSaltzman]

Politics is often simply the art of waiting.

[Becki Saltzman @BeckiSaltzman]

@AnthemBCBS please divorce yourself from @Accredo before patients die as a result of not receiving drugs due to “system error”.

[Becki Saltzman @BeckiSaltzman]

@Zoom Please correct the issue where one is only able to set calendar range to only see upcoming meetings one month at a time!

[Becki Saltzman @BeckiSaltzman]

@BarbraStreisand Cheers to the Democrats for showcasing a commitment to integrity by refusing to blindly support the wrong candidate!

Btw, I loved your book @BarbraStreisand!

[Becki Saltzman @BeckiSaltzman]

Cheers to the Democrats for showcasing a commitment to integrity by refusing to blindly support the wrong candidate.

[Becki Saltzman @BeckiSaltzman]

Beneath every history, another history.

[Becki Saltzman @BeckiSaltzman]

What seems timeless passes into time. #GoodNewsBadNews

[Becki Saltzman @BeckiSaltzman]

There are massive benefits that would come from not conflating gender and sex. A good place to start is with Clara B. Jones.

[Becki Saltzman @BeckiSaltzman]

If you don’t understand why “the other side” isn’t stupid, you haven’t done your homework.

[Spencer Greenberg 🔍 @SpencrGreenberg]

I'm not a person who has idols, but Daniel Kahneman came about as close as it gets for me. It is not an exaggeration to say that he revolutionized our understanding of the mind.

Among many other concepts, Kahneman and his collaborators came up with the ideas of:

• anchoring (where an irrelevant number can influence our judgments)

• prospect theory (a theory of how we make judgments when there is uncertainty that incorporates a number of biases)

• the focusing illusion (where we overemphasize the importance of whatever factor we happen to be focused on at that moment)

• the peak-end rule (where our memories of an event tend to emphasize the peak moment of greatest intensity and how the event ended)

• the planning fallacy (the common bias where people underestimate the time and cost of large projects)

• the availability heuristic (where we evaluate how frequent, likely, or important an event is based on how easily we can recall examples of it to memory)

• the representativeness heuristic (where we evaluate how likely something is to be something else based on how similar it is to a prototype or stereotype rather than incorporating all the information we have, such as base rate information)

I feel grateful to have had the chance to spend a little bit of time with him. He was as wonderful in person as he was in his articles. I once even thought I found an error in one of his papers, and he was so nice about it when I pointed it out. It turns out I misinterpreted what method he used, and the paper was flawless!

The world has suffered a great loss today.

[Becki Saltzman @BeckiSaltzman]

@valhallabckgirl A human work of art.

[Becki Saltzman @BeckiSaltzman]

Cheers and thanks for spreading a new way of advancing critical thinking!

[Nix Good @mrsngood]

@BeckiSaltzman will revolutionize your AI #prompting and engagement! 😎

Check out her course "Amplify your critical thinking" on LinkedIn!👇
https://t.co/KgBD5mE0VQ
#TransformAIConversations #promptingTips #criticalthinkingskills

[Becki Saltzman @BeckiSaltzman]

This year DEI companies will become DEB companies.

[Becki Saltzman @BeckiSaltzman]

Critical thinking isn't the same a being smart. It isn't about strategy or creative solutions. It's about assessing information quality. Here's how #genAI can help...and hinder. https://t.co/20C6Dv6nIp

[Becki Saltzman @BeckiSaltzman]

Perhaps a critical thinking workshop could help?

First hot tip: using absolutes in your argument might be a sign that you’ve slipped in a fallacy.

[Peter Boghossian @peterboghossian]

This is what it looks like when two people who can think clearly talk to two people who cannot think clearly but are good at emoting.

[Becki Saltzman @BeckiSaltzman]

The pace of human evolution was invisible to us humans…until now. Stay curious.

[Amjad Masad @amasad]

This fundamentally changes how humans work with computers

[Becki Saltzman @BeckiSaltzman]

How should scientists conducting and publishing studies involving sex differences think about their use and clarity of concepts of female versus women or male versus men?

[Becki Saltzman @BeckiSaltzman]

I’m going to rethink my use of tags. #lawofattention

[Spencer Greenberg 🔍 @SpencrGreenberg]

Imagine you lived in a universe where whatever you give your attention to gets drawn to you. So if you pay attention to cute dogs on the street, soon you'll be followed all the time by cute dogs. And if you pay attention to the angry guy muttering to himself, soon there will be angry mutterers all around you. This is similar to what new age spiritualism calls the Law of Attraction ("you attract into your life what you focus on").

This is not how the real universe works. But you know what actually does work this way? Social media. Let's call it the law of Social Media Manifestation: you manifest what you pay attention to.

On Facebook, cute animals follow me around because I like cute animal photos. On Twitter, I don't hear many angry guys muttering because I don't click on angry guy mutterings. I do, however, hear many interesting ideas because I click on and like them.

If your social media is hell, don't forget the law of Social Media Manifestation: you manifest what you pay attention to. If you want your social media to be full of interesting ideas and not brimming with angry guy mutterings, click on the former, not the latter.

If the real world worked this way, we might think it would be a paradise (all we have to do is focus on good things, and then good things will be all around us). But what social media teaches us is that if the real world worked this way, many of us would end up in a nightmare.

Fortunately, with social media, it's a nightmare that's pretty easy to wake up from. But it requires clicking and liking based on what your higher self wants you to see rather than what your lower self feels a compulsion to see.

[Manuel Ruiz @manruipa]

🔴𝐕𝐄𝐑𝐘 𝐈𝐌𝐏𝐎𝐑𝐓𝐀𝐍𝐓 𝐓𝐇𝐈𝐒 𝐒𝐓𝐔𝐃𝐘 𝐭𝐡𝐚𝐭 𝐢𝐬 𝐠𝐨𝐢𝐧𝐠 𝐮𝐧𝐧𝐨𝐭𝐢𝐜𝐞𝐝!

𝐓𝐡𝐢𝐬 𝐚𝐫𝐭𝐢𝐜𝐥𝐞 𝐬𝐡𝐨𝐰𝐬 𝐚 𝐜𝐨𝐫𝐫𝐞𝐥𝐚𝐭𝐢𝐨𝐧 𝐛𝐞𝐭𝐰𝐞𝐞𝐧 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐞𝐝 𝐂𝐃𝟒 𝐓 𝐜𝐞𝐥𝐥 𝐥𝐞𝐯𝐞𝐥𝐬 𝐚𝐧𝐝 𝐟𝐚𝐭𝐢𝐠𝐮𝐞 𝐢𝐧 𝐩𝐚𝐭𝐢𝐞𝐧𝐭𝐬 𝐰𝐢𝐭𝐡 𝐋𝐨𝐧𝐠 𝐂𝐎𝐕𝐈𝐃. 📚https://t.co/H413t5ptI9

𝐖𝐡𝐲 𝐢𝐬 𝐭𝐡𝐢𝐬 𝐫𝐞𝐥𝐚𝐭𝐢𝐨𝐧𝐬𝐡𝐢𝐩 𝐢𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐭?

1️⃣ Because it shows an increase in CD4 T cells being 𝐢𝐧𝐞𝐟𝐟𝐞𝐜𝐭𝐢𝐯𝐞 in clearing the infection.

2️⃣ If we add these results with those of the other recently published article 📚 (https://t.co/ff9UmqCHXk ), it also explains that although IFN-γ levels increase chronically, it is incapable in the elimination of SARs-CoV-2 reservoirs in macrophages of different tissues due to the immunosuppressive environment they generate by releasing IL-10. 𝐀𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐜𝐚𝐬𝐞 𝐨𝐟 𝐄𝐁𝐕, B cells with latency of this virus generate reservoirs of cells that release IL-10 together with other factors that prevent T cells from eliminating them. In other words, there are continuous reservoirs that cannot be eliminated by this evasion microenvironment but continuously release viral material outside to which T cells and innate immunity respond.

3️⃣ This eventually leads to 𝐢𝐦𝐦𝐮𝐧𝐞 "𝐞𝐱𝐡𝐚𝐮𝐬𝐭𝐢𝐨𝐧" 𝐨𝐟 𝐓 𝐜𝐞𝐥𝐥𝐬 as they are continually responding to viral antigens from viral reservoirs. In other words, they stop responding effectively.

4️⃣ It also explains the increase in 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐞 𝐝𝐢𝐬𝐞𝐚𝐬𝐞𝐬 in Long COVID patients as an increase in CD4 T levels in response to chronic exposures to viral antigens in various tissues can lead to an increase in autoimmune response. It is common to have autoantibodies during viral infections that disappear after clearance, but if this becomes chronic autoimmunity would develop.

5️⃣ 𝐘𝐨𝐮 𝐦𝐚𝐲 𝐰𝐨𝐧𝐝𝐞𝐫 𝐡𝐨𝐰 𝐢𝐟 𝐂𝐃𝟒 𝐓 𝐜𝐞𝐥𝐥𝐬 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐞 𝐭𝐡𝐞𝐫𝐞 𝐚𝐫𝐞 𝐫𝐞𝐚𝐜𝐭𝐢𝐯𝐚𝐭𝐢𝐨𝐧𝐬 𝐨𝐟 𝐄𝐩𝐬𝐭𝐞𝐢𝐧-𝐁𝐚𝐫𝐫 𝐯𝐢𝐫𝐮𝐬 𝐢𝐧 𝐭𝐡𝐞𝐬𝐞 𝐩𝐚𝐭𝐢𝐞𝐧𝐭𝐬? Because EBV is a very intelligent virus, since it uses the increase of IFN-γ that appears during other infections/inflammation to infect more cells, since IFN-γ increases the expression of MHC-II, and this protein is where EBV infects. In addition, the latent reservoirs of EBV (ectopic lymphoid aggregates) take advantage of the increase in antigen presentations to move from latent to lytic phase, increasing the release of virions. And if we add that these cells are "exhausted" they cannot effectively control latent viruses either.

6️⃣ 𝐀𝐧𝐝 𝐰𝐡𝐚𝐭 𝐝𝐨𝐞𝐬 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐞𝐝 𝐓𝐂𝐃𝟒 𝐡𝐚𝐯𝐞 𝐭𝐨 𝐝𝐨 𝐰𝐢𝐭𝐡 𝐟𝐚𝐭𝐢𝐠𝐮𝐞? An increase in the activation of these cells leads to an increase in their metabolism and an increase in the release of proinflammatory cytokines that result in ongoing oxidative stress. In addition, there is a continuous response of innate immunity because adaptive immunity (CD4 and CD8 T cells) cannot control the infection, thus further increasing oxidative stress. This oxidative stress is responsible for most of the symptoms. For example, if it increases in the CNS, it leads to neuroinflammation and fatigue.

7️⃣ 𝐀𝐧𝐝 𝐰𝐡𝐚𝐭 𝐫𝐞𝐥𝐚𝐭𝐢𝐨𝐧𝐬𝐡𝐢𝐩 𝐰𝐨𝐮𝐥𝐝 𝐭𝐡𝐢𝐬 𝐢𝐧𝐜𝐫𝐞𝐚𝐬𝐞 𝐢𝐧 𝐓𝐂𝐃𝟒 𝐡𝐚𝐯𝐞 𝐰𝐢𝐭𝐡 𝐡𝐲𝐩𝐨𝐜𝐨𝐫𝐭𝐢𝐬𝐨𝐥𝐢𝐬𝐦? Well, a direct relationship. The greater the TCD4 response and innate immunity, the greater the inflammation and the greater the cortisol consumption. Moreover, chronic inflammation can also inhibit ACTH production and thus cortisol production. For this reason, in the short term, some patients with hypocortisolism improve with corticosteroids, but in the long term they worsen because infection increases due to their immunosuppressive effect.

All this follows the same line of 𝐨𝐮𝐫 𝐩𝐚𝐭𝐡𝐨𝐩𝐡𝐲𝐬𝐢𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐦𝐨𝐝𝐞𝐥 of the disease that links the development of an acquired immunodeficiency with the symptomatological consequences in both Long COVID and Myalgic Encephalomyelitis diseases. Link to our model: https://t.co/hdc9KNiyiC

🔄 Share it with other patients so they can understand their disease - 𝐤𝐧𝐨𝐰𝐥𝐞𝐝𝐠𝐞 𝐢𝐬 𝐩𝐨𝐰𝐞𝐫! 📚
#LongCOVID #MECFS #MyalgicEncephalomyelitis #Autoimmune #lupus #RheumatoidArthritis #MultipleSclerosis #Hashimotos #Sjogrens #CrohnsDisease #UlcerativeColitis #CeliacDisease #Health #Research #News #microE2324 #Medicine #ChronicDiseases #SARSCOV2 #COVID #LongHaulers #MCAS #ME #MyE #CFS

@zalaly @WesElyMD @VirusesImmunity @MichaelPelusoMD @resiapretorius @DrAnnaNZ @dbkell @doctor_zeest @dsethlewis @remissionbiome @aftab_usa @edyong209 @exceedhergrasp1 @PlzSolveCFS @long_covid @LCawarenessInt @calirunnerdoc @LongCovidNews @LongCovidAP. @postviraltrials @patientled @loscharlos @ahandvanish @PatientPersists @LisaAMcCorkell @PutrinoLab @doctorasadkhan @MEActNet @LCAIreland @LongCovidAdvoc @LongCovidSOS @loscharlos @EricTopol @chydorina @SarahOC_MECFS @ahandvanish @DoctorsWithME @aboutmecfs @MarekSJF @mecfsambassador @benh_mecfs @MECFSNews @exceedhergrasp1 @mercheborja @MEAssociation @TheClutterer @LongCOVIDPhysio @organichemusic @C19LH_Advocacy

@organichemusic

[Becki Saltzman @BeckiSaltzman]

Free speech works best for those who prioritize learning ‘how to think’ over ‘what to think’.