Claes Andréasson

Prof. at Stockholm University. The molecular cell biology of proteostasis, chaperones and stress signaling. @AndreassonLab

[Frydman Lab @FrydmanLab]

Another great story from Jae Ho Lee in the lab: a new concept in cotranslational proteostasis-ribosome communication via chaperoneNAC. An exciting collaboration with Elke Deuerling's lab @DeuerlingLab and Marina Rodnina's lab https://t.co/XF7wlCrr5W

[ShorterLab @ShorterLab]

In @elife: The ALS-associated co-chaperone DNAJC7 mediates neuroprotection against proteotoxic stress by modulating HSF1 activity https://t.co/shM0CUKcYt

[Yan Holtz @R_Graph_Gallery]

🚨 Stop chasing the p-value!

Increasing your sample size will always yield a significant result.
Even for trivial differences.

🎮 I created a little interactive playground to illustrate this issue:
https://t.co/7yv33PWxIb

Always pair p-values with effect sizes!

[Claes Andréasson @ClaesAndreasson]

@mikaellindstro2 Och att det så ofta hugger till tidigt på morgonen men blir varmare när solen lyser.

[Jonas Klang @jklang]

@thorneby

[Nick Desnoyer @NickDesnoyer]

In one year, I genetically engineered the boring Arabidopsis into a beautiful ornamental flower 🧬🌹

Here is how and why I gave this model organism a visual upgrade 🧵(1/7)

[Verena Kohler @_VerenaKohler]

Activation of endoplasmic reticulum stress in premature aging via the inner nuclear membrane protein SUN2 https://t.co/3QdfiEYnaf

[ShorterLab @ShorterLab]

Brain malformations and seizures by impaired chaperonin function of TRiC | Science https://t.co/zuOLxk3wOs

[ShorterLab @ShorterLab]

In @eLife: Early steps of protein disaggregation by Hsp70 chaperone and class B J-domain proteins are shaped by Hsp110 https://t.co/adcVkoVu8b

[Verena Kohler @_VerenaKohler]

Heat Shock Factor 1 forms nuclear condensates and restructures the yeast genome before activating target genes https://t.co/2cBvtbZULi

[Verena Kohler @_VerenaKohler]

Single-molecule evidence of Entropic Pulling by Hsp70 chaperones https://t.co/W3L6cKRdkB

[Paolo De Los Rios @PaoloDeLosRios]

It was a long time (18 years!) waiting for this demonstration, but it's out, thanks to the leadership of @chancao123 and the great work of Verena Rukes, Mathieu Rebeaud and Louis Perrin.
Entropic Pulling at single molecule resolution!

https://t.co/ziwuDVpeVj

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

[BuchnerLab @buchnerlab_tum]

We are happy to share our latest publication out in Nature Communications! This paper sheds light on the conformational dynamics of Hsp90! Awesome collaboration with @TheKailaLab and the Don Lamb Lab! https://t.co/c3JdGV22tp @NatureComms

[Martin Pacesa @MartinPacesa]

Have you ever wanted to design protein binders with ease? Today we present 𝑩𝒊𝒏𝒅𝑪𝒓𝒂𝒇𝒕, a user-friendly and open-source pipeline that allows to anyone to create protein binders de novo with high experimental success rates. @befcorreia @sokrypton

https://t.co/IPhMFpRgHh

[Jan Riemer @Riemerlab]

Happy to present our latest preprint. We identify adenylate kinase 2 as new interaction partner of apoptosis-inducing factor 1 (AIFM1) thereby linking AIFM1 to cellular metabolism and adaptation to fluctuating energy availability

doi: https://t.co/BOy3FAPQxR

[Will Ratcliff @wc_ratcliff]

Interesting...the virome of the last eukaryotic common ancestor is bacterial, not archaeal.
https://t.co/dkZsaFFoIf

This may be evidence that a bacteria engulfed an ASGARD archaea, rendering it immune from viruses, not the other way around as is typically assumed. Cool!

[Max Perutz Labs Vienna @MaxPerutzLabs]

🚨 New paper in @embojournal! The Karagöz lab has uncovered how IRE1, a crucial transmembrane protein, responds to protein folding stress in the ER and reveals that disordered regions in the luminal sensor domain play a vital role in its self-assembly ➡️ https://t.co/StI5I9QlF5

[Carmen Ruger-Herreros @carmenruger]

Bad agar is killing lab yeast around the world. Where is it coming from? | Science | AAAS https://t.co/AqRBxXpn0d

[AndréassonLab @AndreassonLab]

Our new paper: Misfolded proteins activate HSF1 by releasing it from Hsp70. This has been clear in yeast for some time and we find that the mechanism is similar in human cells. https://t.co/TuLr8q2Ez3