Dexter Jin

Cancer Genomics Scientist @FoundationATCG . Opinions are my own! He/Him.

[Neil Vasan @NeilVasan]

We are pleased to announce our manuscript on pan-cancer multi-PIK3CA mutations, published this week in @CCR_AACR.
https://t.co/HPe7P09q9r

[Foundation Medicine @FoundationATCG]

In collaboration with @CancerResrch, #NewResearch published in @JCOPO_ASCO shows changes in #ctDNA reflect clinical benefit to #patients. Learn more: https://t.co/KQRGlvvUtW #WhatFriendsDoes #ctDNAFriends

[Foundation Medicine @FoundationATCG]

In partnership with @flatironhealth, @genentech and a network of community oncology practices, we are excited to release new research on tumor profiling results from the ongoing Prospective Clinicogenomic (PCG) Study. More on this new data and the study: https://t.co/j3wlx541w3

[Laura Luebbert, PhD @NeuroLuebbert]

gget alphafold: Predict the 3D structure of a protein from its amino acid sequence using @DeepMind’s AlphaFold v2.0 from a Python or command-line environment in 3 lines of code. Runs on any laptop and requires only ~4 GB of disk space. Simply ‘pip install gget’ and:

[Geoff Oxnard MD @geoff_oxnard]

Congrats to the @DeptVetAffairs NPOP on this @sciencedirect report of 3376 Veterans w NSCLC profiled using @FoundationATCG CGP (🔬&🩸). 82% current/former smokers, 41% TMB >=10, and 27.5% LUAD / 2.7% LUSQ had targetable drivers!

https://t.co/u3FMt6Xhte

[Pedro Beltrao @pedrobeltrao]

AlphaFold predicted structures for the full protein universe (200 million). Quite a lot of redundancy in the set but so many discoveries can be powered by this. Novel enzymes, evolution of life, possibly protein dynamics from ensembles. The hart part is how to even analyse it all

[Ethan Sokol @EthanSokol]

Longitudinal sequencing of prostate cancer samples revealed stability in the detection of BRCA2, ATM, and PALB2 during disease progression, suggesting that current or archival tissue can identify these PARPi biomarkers. https://t.co/8LZcFosUvJ

[Joaquin Mateo @quimmateo]

Genomic Biomarkers and Genome-Wide Loss-of-Heterozygosity Scores in Metastatic Prostate Cancer Following Progression on Androgen-Targeting Therapies | JCO Precision Oncology https://t.co/FwIvAirQk2

[Tyler Janovitz, MD, PhD @TJanovitz]

Some great work defining likelihood of NGS results by sample type by colleagues including @DouglasMataMD @RichardHuangMD @geoff_oxnard

Method of Tissue Acquisition Affects Success of Comprehensive Genomic Profiling in Lung Cancer https://t.co/Qfjq0Xos64

[Neeraj Agarwal, MD, FASCO @neerajaiims]

Just in @JCOPO_ASCO @ASCO : practice influencing data from @EAntonarakis 👉 Men with MSI-H #ProstateCancer with BRCAm are unlikely to benefit from PARPi (BRCAm here are bystander mutations). Weblink👉 https://t.co/gBskzw59mf @OncoAlert @FoundationATCG @urotoday @PCF_Science

[Ethan Sokol @EthanSokol]

It’s out! We identify mutual exclusivity between microsatellite instability and HRD. BRCA1/2 mutations in MSI-H tumors are predominantly monoallelic passenger alterations which may not predict PARPi sensitivity. Rather patients may benefit from ICI. https://t.co/OpbKCFPCK0

[Alanna Church, MD @AlannaChurch_MD]

An overview of our recent paper in
@NatureMedicine, "Molecular profiling identifies targeted therapy
opportunities in pediatric solid cancer", led by @janeway_MD

Read it here:
https://t.co/4IuoHGJgP5

[Katie Lannan @katielannan]

Under an executive order Gov. Baker signed today, Mass. "will not cooperate with extradition requests from other states pursuing criminal charges against individuals who received, assisted with, or performed reproductive health services that are legal in [MA]," per his office.

[Sen. Bernie Sanders @SenSanders]

Overturning Roe v. Wade and denying women the right to control their own bodies is an outrage and in defiance of what the American people want. Democrats must now end the filibuster in the Senate, codify Roe v. Wade, and once again make abortion legal and safe.

[Alexandria Ocasio-Cortez @AOC]

FYI: When they tell you to “vote harder” that should also apply to primary elections, too.

The party needs to change and that’s not going to happen on its own.

[Michelle Obama @MichelleObama]

My thoughts on the Supreme Court's decision to overturn Roe v. Wade.

[Dexter Jin @DX_Jin]

@sillysalz Thanks to you as well! Your (and all the co-authors) work on this was so important to getting it across the finish line!

[Dexter Jin @DX_Jin]

@12crc @alegronchi @ProfDMThomas @RobinL_Jones Interesting! The histologic subtype composition of the MDM2 amplified cohort might be an important factor.

[Vivek Subbiah, MD @VivekSubbiah]

💥Just in #fridaymorning 👉Addressing challenges with real-world synthetic control arms to demonstrate the comparative effectiveness of Pralsetinib in RET fusion positive non-small cell #lungcancer #LCSM @OncoAlert @StephenVLiu @DrSanjayPopat @NatureComms https://t.co/vGTZC4ZAyi

[Nature Communications @NatureComms]

#Genomic profiling of 7,494 sarcomas across 44 histologies using #targetedsequencing reveals potential therapeutic targets

#CancerResearch by Gounder et al. @DX_Jin @MSKCancerCenter @FoundationATCG

@NatResCancer

https://t.co/7KR2kOTcWv