science_Toni M. Delorey

Associate Director of technology, at the Klarman Cell Observatory of the Broad Institute. Views are my own.

[Rahul Satija @satijalab]

Want to hear about the latest updates/new techniques in single cell and spatial genomics? Check out my lab's eighth annual Single Cell Genomics Day on March 29. Keynotes from @IdoAmitLab @JD_Buenrostro and Xiaowei Zhuang. Please RT/spread the word! https://t.co/zG98gkckMU

[science_Toni M. Delorey @DeloreyTm]

@hattaca @Yale @YaleMed Congratulations!!!!!

[Ioannis Vlachos // @ioavlachos.bsky.social @ioavlachos]

How does #COVID19 affect the human liver at the cellular level?
Many (even mild) patients have elevated liver markers.
We observe an avalanche of expression & cellular changes, & hepatocytes with SARS-CoV-2 RNA using single cell and spatial transcriptomics
https://t.co/IDluj5sxR5

[Broad Institute @broadinstitute]

In a large international sequencing effort, researchers have identified 10 new genes that elevate or lower a person’s risk of #CrohnsDisease, a form of inflammatory bowel disease. https://t.co/YLyKyC166J

[science_Toni M. Delorey @DeloreyTm]

@hattaca @broadinstitute Yay!!! Congratulations!!!

[Hattie Chung @hattaca]

Profiling the molecular heterogeneity in diverse patients is key to precision medicine & therapeutics. But single cell methods need fresh/frozen tissues (hard to scale), while FFPE tissues are routinely collected. We share single nucleus RNA-Seq for FFPE:
https://t.co/jeozRrNDC0

[William L Hwang @DrWilliamHwang]

Our study on single-nucleus and spatial profiling of pancreatic cancer was published today @NatureGenet and will be the cover story in the August issue: https://t.co/stMOT1NZYc.

[Rahul Satija @satijalab]

We've released an Azimuth API that lets you process, map, and annotate your scRNA-seq dataset with a single R command. Just needs the raw counts matrix as input, and accepts Seurat objects, AnnData (h5ad), or hdf5 files.

Check out the vignette at: https://t.co/1ZF9cIG0rM

[science_Toni M. Delorey @DeloreyTm]

@DrWilliamHwang @RYEbright @dianyang1117 @m_hemberg @BrandonMahal @DanielKimMD @Dr_Luke_Pike @DrVMuralidhar @dbittermanmd @sophia_kamran @mahal_janice @insitubiology @nanostringtech @eric_miller24 @10xGenomics @vizgen_inc Congratulations!!!!!!

[science_Toni M. Delorey @DeloreyTm]

@DrWilliamHwang @BWFUND @LabJacks Congratulations!!!!!

[Broad Institute @broadinstitute]

Using #CRISPR, Broad scientists have built new models of melanoma, the deadliest skin cancer. The findings not only shed light on key mutations in melanoma, but also suggest a new way to study the role of specific genes in other cancers. https://t.co/XHEzmlztQa

[Elena Torlai T @ele_tt]

Wow - it’s out! 🤩Happy to share #EngineeredMelanocytes, new cell models to link #genotype2phenotype in #melanoma devel / progression, out today in @ScienceMagazine. Joint work w/ @eranhodis @johnkwon71 @LeviAGarraway #AvivRegev (& other🌟collabs ⏬) 1/ https://t.co/byKzyc0jxg

[Eran Hodis @eranhodis]

How does a skin cell become melanoma? We built one to find out, to help understand this lethal disease. https://t.co/LmH13QCvGy @ScienceMagazine W/ co-1st @ele_tt, @johnkwon71, & senior author Aviv Regev. Early years joint w/ @LeviAGarraway. And many others in last tweet! 🧵 1/18

[s. @mssanjavickovic]

If you want to work with #tech #innovation, #genomics, #imaging and #spatial #transcriptomics consider joining our group @nygenome We are hiring at all levels - from postdocs to project leads! Look out for adds from my lab or @NYGCtech at https://t.co/aaDj5PqTa3

[science_Toni M. Delorey @DeloreyTm]

@CarldeBoerPhD @TF_binding_bot Time to revive the paper again ? 🤣

[Eeshit Dhaval Vaishnav @_e_d_v_]

'The evolution, evolvability and engineering of gene regulatory DNA'

Our paper(https://t.co/5BuxYHByXV) presents a general framework for understanding and designing gene regulatory DNA sequences, built around an ‘oracle’ that predicts gene expression given a DNA sequence. 1/n

[Eeshit Dhaval Vaishnav @_e_d_v_]

Our @Nature paper is now online:

Paper: https://t.co/5BuxYHByXV
Code: https://t.co/kF0TDfoe4D
Data: https://t.co/sR5Tm1RnpO
App: https://t.co/gWHfihK2Ta

My most sincere thanks to Prof. Aviv Regev, @CarldeBoerPhD, @MIT, @broadinstitute and our collaborators

[s. @mssanjavickovic]

Our second paper in two days! Now - we present 3D spatial Transcriptomics in rheumatoid arthritis patients #3DST #spatial #transcriptomics https://t.co/LO1xMQbrU5

[science_Toni M. Delorey @DeloreyTm]

@mssanjavickovic Wohoo!!!!! Congratulations!!!!

[science_Toni M. Delorey @DeloreyTm]

@mssanjavickovic Congratulations!!!!!!