I'm very happy to have our #endogenous#SkM#EV paper out in @AJPCellPhys. https://t.co/VMPHd2xH2P A beautiful piece of art inspired by our paper (by Andrew Crowe) was selected for the cover. A 🧵 about the science (and our growing pains as a new lab in a new (to us) field)...
New publication from our group. We examine the primary functional consequences of mtDNA mutations across major organ systems. Spoiler: the cumulative mutational burden broadly phenocopies a complex I deficiency. https://t.co/rvTckbmk1Z
New publication in the @JPhysiol where we show evidence of lowering mitochondrial oxidative stress to improve physical function in old mice. We also see initial efficacy in humans over the age of 70 (n=5) - but larger follow-up studies are required. Enjoy!
https://t.co/uelEwwx6WI
Today we report single-cell APEX-seq (scAPEX-seq) — a new method for unbiased mapping of *subcellular* transcriptomes at single-cell resolution. This approach reveals cell states that are not detectable by standard scRNA-seq, and enabled us to identify regulators of CAR T function that improve solid tumor killing.
https://t.co/iAJUj6jBQ4
The first paper from the Crewe lab is online today. We found that macrophage-meditated clearance of EVs is a major determinate of circulating adipocyte EV levels. This clearance is disrupted in obesity. A huge effort by Snigdha Tiash!
https://t.co/Bl3hgB8Ep2
New paper updating the Constrained Energy model w @EricTrexler@CurrentBiology & testing vs Additive model. Punchline: clear evidence for Constrained TEE. Link below
Last week marked 16 years since the Supreme Court’s disastrous decision in Citizens United.
I’ve authored a proposed constitutional amendment — H.J.Res. 122 — to overturn it & over 70 of my colleagues have joined our effort.
I’ll keep fighting to get it across the finish line.
Sharing our latest led by @Triantafyllia14 online today in @Cancer_Cell !
https://t.co/VrJ9bIbvIw
We demonstrate that cytotoxic immune responses metabolically program the lymphatic vasculature to restrain regional metastasis and promote immunity!
@nyulangone@Perlmutter_CC
📢Tenure Track Faculty Position: UW-Madison is expanding its research portfolio in aging and is interested in applicants who study the interplay between aging and skeletal muscle biology. 10 days left to apply - please RT and DM if you have questions. https://t.co/u0dWirW6H6
Really thrilled to share our work on mitochondrial presequence strength @JCellBiol. We establish quantitative parameters to better define "strong" and "weak" presequences in vitro and in vivo. This work was spearheaded by the ever talented Youmian Yan, a grad student in my lab.
We show (again) that: Resistance training load does not determine resistance training‐induced hypertrophy across upper and lower limbs in healthy young males https://t.co/vZC6uHurel
Yet another study showing similar muscle growth when using heavy vs light loads. The evidence is overwhelming on the topic: loading ranges of ~5 to 30 reps build muscle equally. Very nice study design from the lab of @mackinprof 💪 https://t.co/Z9g7oWsOqS
I am extremely pleased to announce that our paper is now published in Nature Communications. Here, we show for the first time that the GLP-1R signals from endosomes by forming contacts with the ER via the ER membrane contact site tethers VAPA and VAPB🧵
https://t.co/OXuZR7qazb
Today, we report a cellular cross-species RNA-seq atlas of myogenesis: Using mouse & human cell culture models combined with in vivo snRNA-seq from muscle we provide a comprehensive resource for investigating skeletal muscle differentiation.
https://t.co/8xLNwIP2Dd
Computational design of insulin proteins that bind to the insulin receptor and "induce different downstream responses."
"We identified designs more potent than insulin, causing longer-lasting glucose lowering in vivo and retaining activity on disease-causing IR mutants..." in mice.
Nice paper from David Baker's group. They made insulin variants that bind to many different parts of the receptor, including partial agonists that bias downstream signaling away from MAPK. The authors solved many of the bound structures as well.
Spatial Multiomics (Metabolome➡️ Lipidome➡️ Glycome) on a single 10 µm brain section👹
+Sami
Spatial Augmented Multiomics Interface
with Small Molecule Pathway Database
Direct pixel-to-pixel matching across modalities😎
@RCSunlab@NatureComms 2025
https://t.co/66INVGwfar