Dan Lark

Studying extracellular vesicle biology in the context of metabolic disease.

Assoc. Prof. in Health & Exercise Science at @CSU

[Dan Lark @ERM_Lab]

I'm very happy to have our #endogenous #SkM #EV paper out in @AJPCellPhys. https://t.co/VMPHd2xH2P A beautiful piece of art inspired by our paper (by Andrew Crowe) was selected for the cover. A 🧵 about the science (and our growing pains as a new lab in a new (to us) field)...

[Dan Lark @ERM_Lab]

Alternative math.

[Aaron Rupar @atrupar]

RFK Jr: "President Trump has a different way of calculating percentages. If you have a $600 drug and you reduce it to $10, that's a 600% reduction."

[Kelsey Fisher-Wellman, PhD @KFW_Lab]

New publication from our group. We examine the primary functional consequences of mtDNA mutations across major organ systems. Spoiler: the cumulative mutational burden broadly phenocopies a complex I deficiency. https://t.co/rvTckbmk1Z

[Kevin O Murray, PhD @KOMurrayPhD]

New publication in the @JPhysiol where we show evidence of lowering mitochondrial oxidative stress to improve physical function in old mice. We also see initial efficacy in humans over the age of 70 (n=5) - but larger follow-up studies are required. Enjoy!
https://t.co/uelEwwx6WI

[Alice Ting @aliceyting]

Today we report single-cell APEX-seq (scAPEX-seq) — a new method for unbiased mapping of *subcellular* transcriptomes at single-cell resolution. This approach reveals cell states that are not detectable by standard scRNA-seq, and enabled us to identify regulators of CAR T function that improve solid tumor killing.

https://t.co/iAJUj6jBQ4

[Shingo Kajimura Lab @KajimuraLab]

Please help us share this information with colleagues who might be interested. Thanks!
https://t.co/tIfSfd1qBM

[Cell Reports Methods @CellRepMethods]

MitoTracker transfers from astrocytes to neurons independently of mitochondria https://t.co/YH8Iv631pD

[Clair Crewe @CreweLab]

The first paper from the Crewe lab is online today. We found that macrophage-meditated clearance of EVs is a major determinate of circulating adipocyte EV levels. This clearance is disrupted in obesity. A huge effort by Snigdha Tiash!

https://t.co/Bl3hgB8Ep2

[ISEV-Journals @ISEV_Journals]

📘Read in #JEV📘 A Sensitive Reporter Mouse Model to Study Adipocyte-Derived Extracellular Vesicles In Vivo https://t.co/Nz1SbXEqoe

[Zhen Yan @ZhenYanLab]

Ampk alpha2 T172 activation dictates exercise performance and energy transduction in skeletal muscle | Science Advances https://t.co/r4L1ug7ssh

[Herman Pontzer @HermanPontzer]

New paper updating the Constrained Energy model w @EricTrexler @CurrentBiology & testing vs Additive model. Punchline: clear evidence for Constrained TEE. Link below

[Rep. Joe Neguse @RepJoeNeguse]

Last week marked 16 years since the Supreme Court’s disastrous decision in Citizens United.

I’ve authored a proposed constitutional amendment — H.J.Res. 122 — to overturn it & over 70 of my colleagues have joined our effort.

I’ll keep fighting to get it across the finish line.

[Amanda Lund Lab @theLundLab]

Sharing our latest led by @Triantafyllia14 online today in @Cancer_Cell !

https://t.co/VrJ9bIbvIw

We demonstrate that cytotoxic immune responses metabolically program the lymphatic vasculature to restrain regional metastasis and promote immunity!
@nyulangone @Perlmutter_CC

[The Hornberger Lab @HornbergerLab]

📢Tenure Track Faculty Position: UW-Madison is expanding its research portfolio in aging and is interested in applicants who study the interplay between aging and skeletal muscle biology. 10 days left to apply - please RT and DM if you have questions. https://t.co/u0dWirW6H6

[Natalie Niemi @nieminm]

Really thrilled to share our work on mitochondrial presequence strength @JCellBiol. We establish quantitative parameters to better define "strong" and "weak" presequences in vitro and in vivo. This work was spearheaded by the ever talented Youmian Yan, a grad student in my lab.

[Stuart Phillips (he/him) @mackinprof]

We show (again) that: Resistance training load does not determine resistance training‐induced hypertrophy across upper and lower limbs in healthy young males https://t.co/vZC6uHurel

[Brad Schoenfeld, PhD @BradSchoenfeld]

Yet another study showing similar muscle growth when using heavy vs light loads. The evidence is overwhelming on the topic: loading ranges of ~5 to 30 reps build muscle equally. Very nice study design from the lab of @mackinprof 💪 https://t.co/Z9g7oWsOqS

[Alejandra Tomás Catalá @TomasLab_ICL]

I am extremely pleased to announce that our paper is now published in Nature Communications. Here, we show for the first time that the GLP-1R signals from endosomes by forming contacts with the ER via the ER membrane contact site tethers VAPA and VAPB🧵

https://t.co/OXuZR7qazb

[Alexander Bartelt @BarteltLab]

Today, we report a cellular cross-species RNA-seq atlas of myogenesis: Using mouse & human cell culture models combined with in vivo snRNA-seq from muscle we provide a comprehensive resource for investigating skeletal muscle differentiation.

https://t.co/8xLNwIP2Dd

[Niko McCarty. @NikoMcCarty]

Computational design of insulin proteins that bind to the insulin receptor and "induce different downstream responses."

"We identified designs more potent than insulin, causing longer-lasting glucose lowering in vivo and retaining activity on disease-causing IR mutants..." in mice.

Nice paper from David Baker's group. They made insulin variants that bind to many different parts of the receptor, including partial agonists that bias downstream signaling away from MAPK. The authors solved many of the bound structures as well.

[Hao Yin @HaoYin20]

Spatial Multiomics (Metabolome➡️ Lipidome➡️ Glycome) on a single 10 µm brain section👹

+Sami
Spatial Augmented Multiomics Interface
with Small Molecule Pathway Database

Direct pixel-to-pixel matching across modalities😎

@RCSunlab @NatureComms 2025
https://t.co/66INVGwfar