Annette Gilchrist

Science nerd, previously studied 7TM receptors & signal transduction and taught med chem of onc drugs & PGx, now working at NIH. Views expressed are my own.

[Eric Topol @EricTopol]

Our immune response loses its integrity and protection as we age. If we're going to promote healthspan, we'll need to counter that loss of function and, at the same time, avoid inducing autoimmune diseases
A new @jclinicalinvest review, open-access https://t.co/7LNIwLmI1c

[Arun K. Shukla @arshukla]

A Hormone Cell Atlas maps the human endocrine system at cellular resolution | Science https://t.co/bclr2iLOha

[Annette Gilchrist @GPCRscientist]

@budget is incompetent, not only did my rental car break down and they charge me a refueling fee for the car that had to be towed, they failed to pay for my uber ride to get to the airport to pick up the replacement vehicle.

[Annette Gilchrist @GPCRscientist]

Not only did my rental car break down, they charged me a refueling fee even though the second car was returned full. I hate @Budget

[Annette Gilchrist @GPCRscientist]

Not only did my rental car break down, they charged me a refueling fee even though the second car was returned full. I hate @Budget

[Craig Spencer MD MPH @Craig_A_Spencer]

Thousands of the best experts at FDA, NIH, and all across HHS are being terminated right now.

These are the people who make sure the medications you and your children take are safe.

These are the people who perform and oversee research on cancer, infant health, and so so so much more.

These are the people who make sure new devices that physicians and patients use are effective.

These are the people who keep workers safe on the job and help prevent devastating injuries for workers all around the country.

These are the people who track what drugs and medications are experiencing shortages so we can adapt.

These are the people who help tackle HIV and other infectious diseases, asthma, lead poisoning, and everything else that makes many Americans sick.

And now, thousands of them are gone.

There is no way this makes Americans healthier.

We will regret this.

[Annette Gilchrist @GPCRscientist]

The voices of the American public at large are being silenced.

https://t.co/rcDFBeLCm0

[Annette Gilchrist @GPCRscientist]

Wondering how the pause in NIH funding affects your state? You can look it up https://t.co/nhStYJy78F

[NIH @NIH]

Multifocal contact lenses slowed progression of nearsightedness (myopia) in children, and the treatment benefit continued even after they stopped wearing the lenses according to results of an NIH-funded study. https://t.co/RX5oos4SUN

[Steven Rattner @SteveRattner]

The share of Americans employed by the government steeply dropped in the decades leading up to 2000, and has remained essentially flat since. A bloating federal workforce is a myth.

[nature @Nature]

Exclusive: These universities have the most retracted scientific articles

A first-of-its-kind analysis reveals which institutions are retraction hotspots

Read the full story here: https://t.co/bqU2Hg3iXs

[Olivier George @brainaddiction]

It's clear that many do not understand what @NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment

Every single new drug approved by the FDA from 2010–2016 was built on NIH-funded research—that’s all 210 drugs. But what the public sees is just the tip of the iceberg.

Pharma takes credit for the final product, but beneath each drug developed, there are ~20 years of basic research, and 90% of the cost is from basic research funded by the NIH, which discovers drug targets, understands disease mechanisms, and creates life-saving treatments.

Figuring out how cancer evades the immune system, how addiction rewires the brain, and how heart disease develops is the role of the NIH, creating the foundation for the breakthrough drugs that come 20 years later, and the NIH does all that with only 0.8% of the US budget.

Without NIH, there would be no cancer immunotherapy, no anti-overdose medication, no anti-heart attack or stroke medication, no cutting-edge treatments.

If NIH funding is cut, the iceberg will melt. That means fewer cures, more suffering, and more lives lost.

The science beneath the surface keeps us afloat.
Invest in NIH. Invest in life

[Annette Gilchrist @GPCRscientist]

This! https://t.co/qDW8cQI6CW

[Science Magazine @ScienceMagazine]

Researchers have demonstrated that CAR-T cells can transfer tumor-specific receptors to T cells in mice via trogocytosis, endowing recipient cells with antitumor immunity.

Learn more in @SciImmunology: https://t.co/06y62ivjdZ

[C. Michael Gibson MD @CMichaelGibson]

Woah

The government used to pay academic institutions 60% + on top of the costs of research grant to cover “Indirect costs”

That number just dropped to 15%

The viability of US academic medical centers & research is at risk

[Genetic Engineering & Biotechnology News @GENbio]

A new study in mice demonstrates that Alzheimer’s-like tau deposits in the brain lead to the accumulation of cholesterol known as cholesteryl esters, which may be a new therapeutic target. Read more: https://t.co/SGEuCHrmK8

[Retraction Watch @RetractionWatch]

“How one scientist uncovered identity theft, fictitious authors, and plagiarism.”
https://t.co/EPPxzbND4C

[Annette Gilchrist @GPCRscientist]

@gunsnrosesgirl3 How could you miss the military issued P-38?

[Annette Gilchrist @GPCRscientist]

Just how overpriced are the passport photos @upsstore #7707 you ask… Advertised at $12.99 in June 2023 were $19.99 today, but didn’t know til I had to pay. Not noted anywhere. Talk about #inflation, clearly happening @UPS. Next time will go elsewhere.

[Annette Gilchrist @GPCRscientist]

https://t.co/pA26hWGJwX

[Annette Gilchrist @GPCRscientist]

I hate @lyft and @uber when they jack the prices at conventions, in this case #hlth2023 in Vegas. Waited over 20 min on the apps as they looked for drivers just to have the price triple.