Grigory Tagiltsev

Currently postdoc in @BriggsGroup @MPI_Biochem | PhD @ScheuringLab @WeillCornell | structural biology, biophysics, cryo-tomography, atomic force microscopy

[Grigory Tagiltsev @GrigoryTag]

This is a short video description of our recent work.
Elastically loaded clathrin lattices relax to increased curvature after AFM nanodissection.
@ScheuringLab @ScienceAdvances

https://t.co/fnVGvW3fEt

[Simon @simonmb92]

This is a molecular dynamics visualization of TGF-β receptor 1, created in @Blender using #MolecularNodes. TGF-β pathway regulates many cellular processes including cancer formation. 1+ month of dedicated work from system prep to final render. #sciart #b3d #md #cancerdrugs

[Shifra Lansky @ShifraLansky]

Check out our new paper in @NatureComms!
We report a much improved structure of the TRPV3 pentamer, analyzing its high permeability capabilities and its mechanistic ability to reversibly transition to and from the canonical tetrameric state.
@ScheuringLab
https://t.co/YPAgAg1FDY

[Fitzpatrick Laboratory @FitzpatrickLab]

Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors

Now, an exciting collaboration between our labs @ColumbiaBiochem reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online @CellCellPress!

https://t.co/o6AQqpmuJo

[John Briggs @BriggsGroup]

Mature #HIV-1 contains >2000 copies of “spacer peptide 2”, but we didn’t know why. We now see that SP2 binds the matrix protein and triggers the change into its mature arrangement. Summary video from @MargotRiggi :

[Grigory Tagiltsev @GrigoryTag]

@Colom_D Thank you, Adai 🙂

[Grigory Tagiltsev @GrigoryTag]

Was excited to determine the in situ clathrin structure for this project! That’s my first EM-structure upload to EMDB. Can I tell my mom I am a structural biologist now? 😄 #cryoET

[Abhay Kotecha @AbhayKot]

We performed subtomogram averaging on complexes from >3 MDa to ~200 kDa, including 80S ribosomes, Rubisco, clathrin, microtubules, ATP synthase photosystem II, and nucleosomes. Most density maps achieved sub-nanometer resolution!🔬✨ #CryoET #StructuralBiology #VisualProteomics

[Grigory Tagiltsev @GrigoryTag]

@PlentyOf_Room Thank you:)

[Grigory Tagiltsev @GrigoryTag]

Finally out!!! 🎉🎉🎉

[Abhay Kotecha @AbhayKot]

Excited to share our new preprint and 1800+ tomograms with the community! 🎉 This is our first step towards building a visual proteomics dataset for Chlamydomonas reinhardtii. I hope the community will be able to make good use of this data!🔬#CryoET
https://t.co/PVNsnG4WFQ

[Beatrice Ramm @BeatriceRamm]

Thrilled to announce that in January I will be opening my own lab at the Friedrich Miescher Laboratory/@MPI_Bio of the Max Planck Society @maxplanckpress in lovely Tübingen, Germany!

[Grigory Tagiltsev @GrigoryTag]

New preprint from my awesome labmates! It was really cool to watch from the front seat how this story unfolds! Congrats James Stacey, @F4ustus, @BriggsGroup and co-authors! 🤩

[Dominik Hrebik @F4ustus]

Our new preprint is out: we solved the structures of HIV-1 matrix (MA) from intact virions by SPA. The structure led us to a surprising discovery resolving a long mystery in HIV-1 biology – peptide SP2 regulates the maturation of the HIV-1 matrix. 🧵1/x
https://t.co/oBuTqvsdTN

[George Heath @George_R_Heath]

🎉 NanoLocz is Celebrating Its 1st Birthday! 🎉
To mark this milestone, we’re hosting some User Meetings for new and experienced users (all are welcome). An open session to share tips, feedback, ask questions, or simply observe to see if it can help your own #AFM analysis.

[Oleksiy Kovtun @KovtunOleksiy]

We are looking for a #PhD student to study #MolecularMachines driving #membranetrafficking by #cryoEM #cryoET #temtomo. Image processing fans are particluarly welcome.

[alexander.belyy @alexanderbelyy1]

Using #Ftractin to visualize #actin in living cells?
We determined the F-tractin-F-actin structure and showed that the probe is nearly identical to #Lifeact. Check out light microscopy by Athul Sivan @RolandSoldner and #cryoEM by @DmitryShatskiy and me https://t.co/xdUooVyzhy

[Jenny Sachweh @JennySachweh]

Happy to share that our preprint on the regulation of NPC (a)symmetry is online! #teamtomo #NPC #phdlife

Wouldn't have been possible without the support of the amazing @Beck_Laboratory and great collaborators outside @svenklumpe, @MandyBoermel, @WilflingFlorian!

[Crina Nimigean @CrinaNimigean]

Sharing our latest paper! Congrats to @thon_oli, @iHeart_proteins and Zhihan Wang for their amazing work! PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK https://t.co/NJ2VLtBDhX
@WCMAnesthesia, @WeillCornell, @MBiophys_WCMSKI

[Ben Engel @bengeliscious]

Congrats to @biozentrum @snsf_ch Ambizione Group Leader @FlorentWaltz on this stunning study🤩 of respirasome structure & organization inside native cells! It's amazing how quickly in situ #cryoET is advancing. Read Florent's thread🧵 for the high-resolution details🔎🦠 #TeamTomo

[Grigory Tagiltsev @GrigoryTag]

😍😍😍

[Florent Waltz @FlorentWaltz]

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳
Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria! 
https://t.co/cxHl1j20CJ

[Grigory Tagiltsev @GrigoryTag]

@AlisaIakupova my US visa had been in admin processing for 1.5 years already 😂, the first 5 processings took one month each

[George Heath @George_R_Heath]

PostDoc Position Now Open!
🎞 Join our High-Speed AFM team in Leeds
Application Deadline: 1st September 2024

Apply Online Here: https://t.co/vfT804bZHb

[Grigory Tagiltsev @GrigoryTag]

Wow!! Congrats!!!

[Shifra Lansky @ShifraLansky]

I have just opened my lab at the Weizmann Institute of Science, Department of Chemical and Structural Biology, and am looking for students!

Please share! :)

For more details, check out my website: https://t.co/4byF7MsHfy