The Gu Lab

Lab of Chenghua Gu - Neurobiology Department @HarvardMed focusing on neuro-vascular interactions🧠

[Cell @CellCellPress]

Now online! Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling https://t.co/2McZ2zHKDf

[The Gu Lab @GuLabNeuro]

Ever wonder who your cells are talking to? Now you can find out. Plasmids to perform the non-invasive gap junction tracing described in our recent Cell study are now available from Addgene! You can find them here: https://t.co/deLX2jf0io

[The Gu Lab @GuLabNeuro]

We’re excited to share our recent study published in @CellCellPress! In this work, we show that brain endothelial cells, connected by gap junctions, form a signaling highway to enable fast, long-range arterial vasodilation in neurovascular coupling.
https://t.co/wKoVnD2dbf

[The Gu Lab @GuLabNeuro]

New paper out in @NatureNeuro! https://t.co/ocf4wF8djc

[The Gu Lab @GuLabNeuro]

Congratulations to our newly minted Dr. Hannah Zucker!

[HarvardBrainScience @harvardbrainsci]

Researchers Uncover Signal Needed for Blood-Brain Barrier
HMS News article on new research from @SeanMegason, @gulabneuro, Allon M. Klein, and colleagues, first author @NatashaOBrown1

https://t.co/PWeVkjaTqa

[The Gu Lab @GuLabNeuro]

Out in press! With @AndyShih_Lab @Rconstantino @Mishra_CBF_Lab @Mishra_CBF_Lab @SusanneVanVeluw @Rconstantino

https://t.co/j1v2aQ2VOc

[Anusha Mishra @Mishra_CBF_Lab]

Humbled to participate in this scientific statement - I learned so much!
The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the AHA/ASA
https://t.co/IckYJa4Mec

[AHA Science @AHAScience]

A new scientific statement examines the neurovasculome, shedding light on the relationship between the brain & its vessels and its roles in cognitive function.

✍️ @costantinoiade1 @GuLabNeuro @Mishra_CBF_Lab @MisraMD @SusanneVanVeluw

📍 @StrokeAHA_ASA: https://t.co/DGhfOdHzmZ

[Neurobiology Imaging Facility at Harvard Medical @HMS_NIF]

Happy #FluorescenceFriday
Image by @urs_langen, @GuLabNeuro of astrocytes (green, GFAP) in median eminence in touch with blood vessels (red, CD31)
Image was acquired on a @LeicaMicro #SP8 confocal and processed using
@ImarisSoftware

[Neurobiology Imaging Facility at Harvard Medical @HMS_NIF]

#FluorescenceFriday image by @urs_langen, @GuLabNeuro @harvardmed - red blood cells (green) in brain capillary (red)
Image was acquired on a @LeicaMicro #SP8 confocal and processed using @ImarisSoftware

[Neurobiology Imaging Facility at Harvard Medical @HMS_NIF]

#microscopymonday image by @xjdumaine, @GuLabNeuro using our #VS120 slide scanner
Here is the mouse choroid plexus, a structure in the brain ventricles that produces a clear fluid called CSF that helps to protect the brain and clear waste from it. The choroid plexus consists...

[The Gu Lab @GuLabNeuro]

New lab photo + behind the scenes 📸

[The Gu Lab @GuLabNeuro]

Farewell happy hour yesterday for our lab manager Chris - we’ll miss you! + congrats to our former postdoc, Swathi, and Chris for their recent paper🎉

[Sarah Lutz @lutzlab]

We had a lot of fun writing this @NeuroCellPress N&V in Neuron on exciting new story from @GuLabNeuro. identifying a new way for pericytes to suppress BBB transcytosis. Open access @NeuroCellPress https://t.co/EM4EVURt4l

[The Gu Lab @GuLabNeuro]

@wenbin_tan It doesn’t efficiently transduce ECs in most peripheral organs

[The Gu Lab @GuLabNeuro]

Plasmids to generate AAV-BI30, our vector that can specifically manipulate CNS endothelial cells, can be found on Addgene:
https://t.co/YIPtZN5x2L

[The Gu Lab @GuLabNeuro]

@RuiBenedito_ Not yet!

[The Gu Lab @GuLabNeuro]

https://t.co/IMF78JflKp

[Nature Cardiovascular Research @NatureCVR]

Technical Report| @gulabneuro @DevermanLab identify an #AAV variant (AAV-BI30) with high specificity and efficacy for transduction of #endothelial cells across the #CentralNervousSystem. @broadinstitute https://t.co/UGP736siYv

👉https://t.co/5AJsJxTrAS