Jason Colasanti, PhD

Engineering AI for healthcare, aging, and longevity | Prev: Sci Advisor @VitaDAO; research @Aptelab

[Ben Shenhar @BShenhar]

Our new paper on reassessing the heritability of human lifespan is out in @ScienceMagazine! 🧬
For decades, the consensus has been that genetics explains just 20–25% of lifespan differences. We found that after accounting for extrinsic mortality, that number jumps to ~50%.
A 🧵

[Aging Science News @AgingBiology]

FDA clears first human trial of epigenetic reprogramming therapy
https://t.co/qy26b2G6TV

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Randomized, placebo-controlled, double-blind clinical trial on the contributions of vitamin D in the control of cardiovascular risk factors, depressive symptoms and suicide risk

Authors: "Weekly administration of 50,000 IU of vitamin D for six months proved effective in reducing depressive symptoms and suicide risk while improving cardiovascular health markers, highlighting its promise as an accessible, low-cost adjunctive therapy in psychiatric and primary care settings."

https://t.co/tgSYmdEDVp

[Jason Colasanti, PhD @JasonColasanti]

@agingdoc1 E) Evidence-based. IMO, the only supplements worth taking are those that have shown benefit in human clinical trials, and I’ve found these overlap with @BradStanfieldMD ‘s supplement stack (i promise he did not pay me to say this 😅).

[Ronnie Cutler @cutleraging]

Epigenetic reversal will likely not be enough for radical lifespan extension https://t.co/u4TZa9MQdq

[Jason Colasanti, PhD @JasonColasanti]

@malikules and dot com domain names

[Aging Science News @AgingBiology]

Organ-specific proteomic aging clocks predict disease and longevity across diverse populations
https://t.co/pZ62ljvlpL

[Karl Pfleger @KarlPfleger]

@EricTopol @Stifel Infographics are poor ways to track aging biotechs.
https://t.co/iN88rddRNv has a more comprehensive list w/ category + details like pipeline status, $ raised, # employees. Fully sortable/filterable.

289 biotechs currently & 180+ more on the to-be-considered tab (vs 75 above).

[Laura Minquini @LauraMinquini]

One of the saddest realizations being in tech is that a lot of capital allocation happens on vibes, networks, fomo, and marketing.

I have said this to a lot of our researchers; the best and most rigorous science does not necessarily win.

The downstream effects of that is that we probably have a very big graveyard of real scientific innovation (actual cures, therapeutics and more), while questionable projects have millions.

[Jason Colasanti, PhD @JasonColasanti]

@Dr_Singularity That’s my wife! Shout out to @AriellaStudies

[Jason Colasanti, PhD @JasonColasanti]

🎉 Congrats to @AriellaStudies on her new publication based on her thesis work! 👏🍾

[Aging Science News @AgingBiology]

Six Drivers of Aging Identified Among Genes Differentially Expressed With Age
https://t.co/rRiER7ioJM

[Logan Thrasher Collins @LoganTCollins]

An interesting perspective. What regulatory pathway will 3D printed organs take to along the way to the market? Will there be restrictions on IP in the context of 3D printed organs? This article explores these questions.
https://t.co/reaa3uvTdG

[Agingdoc🩺Dr David Barzilai🔔MD PhD MS MBA DipABLM @agingdoc1]

Anti Aging Breakthrough: Stem Cells Reverse Signs of Aging in Monkeys.

Buzzing lay article (Titled above & image): https://t.co/u379TRvt8a

Original Study: https://t.co/13qpNSGjCJ

🤔Author interpretation: "This study provides initial evidence that genetically modified human mesenchymal progenitors can slow primate aging, highlighting the therapeutic potential of regenerative approaches in combating age-related health decline."

Share your data-driven📊 comments below 👇

[Jason Colasanti, PhD @JasonColasanti]

We may finally have some reliable biomarkers of aging/longevity

[Aging Science News @AgingBiology]

Eight decades of follow-up link life course exposures to proteomic organ ageing and longevity
https://t.co/2003HgMd5v

[Alex Colville @AlexJColville]

Introducing the 1st annual pharma aging report card!! The race is on to see who will positively transform humanity and in the process unlock a bigger market than obesity.

[VitaDAO 💛 @vitadao]

Gero, backed by the VitaDAO community, just landed a $1B+ deal with Chugai (Roche)!

Their AI finds the root causes of age-related diseases → Chugai develops antibody drugs from these discoveries.

Big leap forward for longevity research 🧬
https://t.co/HSdz0GIqpe

[Aging Science News @AgingBiology]

Escaping ageing through Cell Annealing—a phenomenological model
https://t.co/8GXvVbDFPu

[Jason Colasanti, PhD @JasonColasanti]

@Replacing_Aging Congrats! Looking forward to it!

[ARPA-H @ARPA_H]

NEW: No technology currently exists to repair damaged brain tissue and fully restore lost function. FRONT aims to enable millions with what is considered permanent brain damage to regain lost functions, including motor control, vision, and speech. https://t.co/uaAhiQV7bf

[Hamilton Oh @hammy_oh]

I'm thrilled to share our new study out in @NatureMedicine! We show that a blood test can estimate how aged or youthful one’s organs are and that these organ ages predict future disease and lifespan. Final paper from my PhD in the @wysscoray lab. 🧵1/12
🔗 https://t.co/2bxtfEJ0TS