Kriwacki Lab

The Kriwacki lab seeks to understand the role of conformational disorder in protein function. Account run by lab members. @StJudeStructBio

[Journal of Molecular Biology @JMolBiol]

And coming in at #1 as the most downloaded article of 2023 with over 8000 downloads is “Phase Separation in Biology and Disease; Current Perspectives and Open Questions” by corresponding authors @SElbaumG and @kriwacki (all authors listed below). https://t.co/Rb6viuz6rF

[Dewpoint Therapeutics @dewpoint_tx]

Read our latest @JMolBiol perspective by @ewmartin, Christiane Iserman, Balaji Olety, @DiaMitrea & @IsaacAKlein reviewing the role of #condensates in the viral replication cycle and discussing novel strategies to target them for novel antiviral therapies: https://t.co/OIAMtqnJMW

[Takashi Fukaya @FukayaLab]

Had a nice science discussion with very tasty sushi!! @DanfengCai @kriwacki @JuliaZeitlinger @bsabari @ywiwasaki

[Takashi Fukaya @FukayaLab]

Thanks to all the speakers and audiences for today's RIKEN symposium!! Photos: @JuliaZeitlinger @kriwacki @EMakeyev @bsabari

@ywiwasaki and I also organise MBSJ sympodium starting from 9:30am tomorrow [1AS-11: Molecular dynamics of gene regulation]. Please check it out!!

[Trends in Biochemical Sciences @TrendsBiochem]

Online now - the Scientific Life article "Dissecting the biophysics and biology of intrinsically disordered proteins" from @BanerjeeLab_UB @alexholehouse @kriwacki @PaulRobustelli Hao Jiang @AlexanderSobol6 @jennifermhurley and @Mendell_lab.

https://t.co/YQGFfRple4

[Cancer Research @CR_AACR]

Read the In the Spotlight commentary in this issue—
Dissolving fusion oncoprotein condensates to reverse aberrant gene expression, by @HazheenM, @bappa_academic, and @Kriwacki discussing a recent @nchembio paper from Wang et al.
https://t.co/Lo6tzo16BZ

[Kriwacki Lab @kriwacki]

Another terrific presentation from postdoc @bappa_academic at #2023FusOnC2.

[Kriwacki Lab @kriwacki]

Great representation from St. Jude at #2023FusOnC2, including our own graduate student @brittpioso and postdoc @maiti_snigdha.

[Kriwacki Lab @kriwacki]

Screening drugs that can modulate aberrant transcriptional condensates formed by fusion oncoproteins. We highlight this exciting work from Pilong Li et al., in this Spotlight for @CR_AACR. @HazheenM @bappa_academic

Dissolving Fusion Oncoprotein Condensates to Reverse Aberrant Gene Expression https://t.co/cssSZgSmev

[Nature Chemical Biology @nchembio]

A new paper from Pilong Li revealed that cancer-causing fusion proteins can form abnormal condensates and developed a screening method called DropScan to dissolve the condensates to restore normal gene expression. Free to read link at https://t.co/sESFwG16tq

[Nature Communications @NatureComms]

The authors report the analysis of physicochemical features to enable prediction of fusion oncoproteins condensation behavior.
@kriwacki
https://t.co/1yh0fAYjLX

[Priyanka Dogra @PriyankaDogra07]

I’m elated to share that I’ve been featured in the Student Spotlight section of the @BiophysicalSoc Bulletin. I’m grateful to my mentors @SamratLabMohali @MilyBhLab @kriwacki for their invaluable guidance and support, which made this recognition possible.

[Chia-Hsueh Lee @TheCHLeeLab]

We're on the hunt for a dynamic Cryo-Electron Microscopy Director.
We currently have excellent instrumentation: 2 300 kV (Krios G3 and coldFEG Krios G4 + falcon IV + selectris), 1 200 kV Arctica, and a Talos L120C.
https://t.co/j6dY4MUUv3

[IDP GRC @GrcIdp]

It's Friday! A fantastic time to remind all disordered protein🍝fans that the Gordon Research Conference on IDPs is accepting applications! Please register soon since space is limited: https://t.co/XwYhmO5SIu

(...and this would be the view from your hotel room window)

[Nature Biotechnology @NatureBiotech]

A genome-wide view of disordered proteins #NBTNV https://t.co/fjp9udgsHn

[Diana Mitrea @DiaMitrea]

Congratulations team on this exciting and valuable resource, demonstrating the broad implications of aberrant condensation in oncology!

[Structural Biology at St. Jude Children's Hospital @StJudeStructBio]

Out in @NatureComms — a valuable resource to understand the role of fusion oncoproteins in cancer, stemming from multidisciplinary efforts led by @kriwacki with @SahniLab, Jinghui Zhang @CMullighan @m_madan_babu @StephenYiLab

https://t.co/dXM7jVCkxW