Kudla lab

Group at @mrc_hgu @EdinUni_IGC @EdinburghUni, using synthetic biology and machine learning to understand genotype-phenotype relationships in RNA and proteins.

[Kudla lab @kudlalab]

Codon optimization: #Pfizer #BioNTech vs #Moderna

https://t.co/O6mUsQLyxN

[Joe Marsh @jmarshlab]

Excited to see this work led by @kudlalab is now out, showing that PAX6 DNA binding measured in a yeast 1-hybrid deep mutational scan outperforms existing computational approaches for variant classification https://t.co/BDrLr4McLH

[Joe Marsh @jmarshlab]

Excited to share our Perspective on the new AlphaMissense variant effect predictor tool from @GoogleDeepMind @ScienceMagazine https://t.co/oSVhhyo3Ei

[Kudla lab @kudlalab]

We have an open postdoctoral position on deep mutational scanning of transcription factor genes @kudlalab @mrc_hgu @varianteffects. Apply by 4th October! https://t.co/mwsUy7gbwx

[Kudla lab @kudlalab]

Hey @BBCSport, it's HOObert HOORcatch, not HUEbert HERcatch. In Polish, the letter "U" is always pronounced "OO". Simple.

[MRC_HGU @mrc_hgu]

Our partners @IIMCB_Poland are recruiting junior group leaders - excellent support available to start your independent career in this internationally recognised and vibrant scientific environment

[Kudla lab @kudlalab]

These are good points @lichuan_Bio @Xukang_AA.

[Kudla lab @kudlalab]

Thanks for these kind words @AbbeAtSea. Looking forward to meeting you and many other codon usage enthusiasts at our EMBO Workshop in Edinburgh next week!

[The Lab LaBella @Lab_LaBella]

Only 1 more week until the #EMBO_CU22 conference co-organized by Grzegorz Kudla @kudlalab at @EdinUni_IGC. Professor Kudla has made significant findings in the codon world by combining synthetic biology, next-gen sequencing, and computational modelling
#3rdBaseThurs @rokaslab

[Igor Ulitsky @IgorUlitsky]

Nothing in genomics or transcriptomics makes sense except in the light of G/C content

[Thomas Christie Williams @Williams_T_C]

our paper is now out @Nature ! https://t.co/G953ET9v7Z

a 🧵on the excitement and value of Basic Science, DNA replication and repair, teamwork and collaboration, and the fundamental incompatibility of LEGO and DUPLO 1/n

[Duncan Sproul @sproul_lab]

This is the best lab trick I've seen in ages.

[Kudla lab @kudlalab]

Join us in Edinburgh for the 1st EMBO workshop on codon usage function, mechanism and evolution. Three weeks left to register!

[MRC_HGU @mrc_hgu]

Excited to be hosting an outstanding and diverse array of researchers with insight on the codon usage bias phenomenon. 1st EMBO workshop on codon usage function, mechanism and evolution at the Royal College of Physicians of Edinburgh, April 8-11, 2022
https://t.co/rtYtQp4oZL

[Kudla lab @kudlalab]

Antibiotic resistance in the pathogenic bacterium Klebsiella pneumoniae mediated by a single synonymous mutation in outer membrane porin gene @TheFrankelLab @RouskinLab.
https://t.co/ZA2tg5osfT

[Bloom Lab @jbloom_lab]

We’ve created calculator that aggregates deep mutational scanning data to estimate how mutations to #SARSCoV2 RBD affect recognition by human polyclonal antibodies. The calculator emphasizes extensive antigenic change in #Omicron variant. https://t.co/hFhwcKED0o (1/n)

[EMBO Events @EMBOevents]

Add your name! Registration now open for the EMBO Workshop on RNA: Structure meets function, 27 June – 1 July 2022 in Åkersberga, Sweden https://t.co/vFbz6RTw0M #EMBOrna

[Kudla lab @kudlalab]

@zany1983 We think that GC-poor variants are not efficiently transcribed, assembled into mRNPs and/or exported when expressed from a plasmid. Transfecting such variants as mRNA circumvents these bottlenecks.

[Kudla lab @kudlalab]

Proud of @CMordstein for spearheading this!

[Christine Mordstein @CMordstein]

👉 Transcription, mRNA export and immune evasion shape the codon usage of viruses

Happy to see another joint-effort from @KudlaLab & @Prof_LDHurst lab out now @GenomeBiolEvol https://t.co/Vn0ajG0XHF

We tried to address some fundamental questions re virus codon usage:
(short🧵)

[Igor Ulitsky @IgorUlitsky]

New preprint!📜📢 "Structural features within the NORAD long noncoding RNA underlie efficient repression of Pumilio activity". A great collaboration between Sveta from my lab, @omerz213 @ericmiskalab @ericmiska and @kudlalab .
What did we find? A 🧵 https://t.co/V7LPoF0Ujq 1/11

[News from Science @NewsfromScience]

The #AI revolution in protein structure prediction continues, as researchers have unveiled a combination of programs that can determine which proteins are likely to interact with one another and what the resulting complexes look like. https://t.co/xMddQBm2pt

[Kudla lab @kudlalab]

@oromncrna If your preprint was published under a copyright license, you should inform the publisher of the other paper that they are infringing the copyright, and ask them to withdraw the paper. Good luck with this ;)

[MRC_HGU @mrc_hgu]

Application is now for our 4 year #PhD programme including Human Genetics, Genomics and Disease and projects for International Quantitative Scientists. Closing date 7 January 2022, details here:
https://t.co/a0rZxFyOH2

[Kudla lab @kudlalab]

Accessibility of translation initiation sites is the strongest predictor of heterologous protein expression in E. coli
https://t.co/ZWIuEVp4V9