Lorena Zuliani Alvarez, PhD

Principal Scientist @Novartis IOH. Interested in viruses, immunology and gene therapy 🧪🦠🧬

[Trevor Van Eeuwen @_themovingvan_]

So excited to share our story revealing structures, functions and adaptations of the human LINE-1 retrotransposon, an ancient genetic parasite that has written 1/3 of the human genome and is implicated in cancer, aging, & autoimmunity. Now out in @Nature https://t.co/wyo0fTUn4e

[Jonathan Kagan @jkagan1]

30+ years after caspases were found to be interleukin-1 converting enzymes (ICE), the first caspase-cytokine structure is revealed. We identify caspase-4 as a specific pro-IL-18 converting enzyme and describe the CryoEM structure of this enzyme-substrate interaction.

[Immunity @ImmunityCP]

CD8+ T cells in the cancer-immunity cycle: CD8+ T cells are “end effectors” of cancer immunity. Wherry, Kaech, Giles, & Globig review the current understanding of CD8+ T cell differentiation and function in cancer, discussing recent advances within a four-signal framework that incorporates T cell metabolism and the impact of the tumor microenvironment. https://t.co/CJrJSwlySe

[Lisa Miorin @LisaMiorin]

I'm so excited that our latest work addressing the role of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis is officially out today in @cellhostmicrobe !!!
https://t.co/DRdq3dxbQZ

[Krogan Lab @KroganLab]

Officially out in @CellCellPress: Systematic comparison of SARS-CoV-2 variants of concern (Alpha, Beta, Gamma, Delta, & Omicron) using global proteomic and genomic analyses during infection to understand the molecular responses driving viral evolution 🧵👇 https://t.co/TXvwbN0MsK

[Veit Hornung @v_hornung]

Here is a nice tweetorial from @SophiaMaedler with some more information on the computational aspects of our SPARCS approach.

https://t.co/JE9v6NA8Vz

We are happy to share reagents and help establishing the protocol already pre-publication.

Please RT.

[Mehdi Bouhaddou, PhD @DoctorBou]

I am looking to hire a Staff Research Associate @UCLAQCBio @MicrobioUcla to serve as a lab manager and perform wet lab experiments related to mass spectrometry proteomics, virology, and molecular biology. If interested, please apply: https://t.co/5pkF4CfShV

[John Walter @johnwalterart]

Thanks to everyone who came to #LoungeLigands last night @QBI_UCSF it was a great success @BShoichet thanks to @LorenaZAlvarez and @poleary87 for the photos

[Lorena Zuliani Alvarez, PhD @LorenaZAlvarez]

@donna_mallery Thank you Donna!

[Lorena Zuliani Alvarez, PhD @LorenaZAlvarez]

@LisaMiorin Thank you Lisa! Talk to you soon

[Lorena Zuliani Alvarez, PhD @LorenaZAlvarez]

What makes HIV-1 pandemic? Our paper (@towerslab) elucidating the role of capsid in driving HIV innate immune evasion and pandemic potential is finally out in @NatureMicrobiol https://t.co/ahW9FMEAgS 🧵👇

[Lorena Zuliani Alvarez, PhD @LorenaZAlvarez]

@GroveLab @towerslab @NatureMicrobiol Thank you Joe!

[Lorena Zuliani Alvarez, PhD @LorenaZAlvarez]

@PeacockFlu @towerslab Thank you Tom! I hope to see you soon

[Towerslab @towerslab]

Our @NatureMicrobiol asking what’s special about pandemic HIV Capsid is finally out. Thanks to @LorenaZAlvarez for her green fingers, patience and general brilliance. Here’s some answers to the questions we get from eg @stuartjdneil

[Lorena Zuliani Alvarez, PhD @LorenaZAlvarez]

@NicolasManelLab @towerslab @NatureMicrobiol Thank you!

[Lorena Zuliani Alvarez, PhD @LorenaZAlvarez]

@stuartjdneil @towerslab @NatureMicrobiol Yes, this is key question that we also had and a possibility. Another is about tropism: in vivo SIVsm only replicates in T cells but not in the myeloid compartment, so maybe no need to evade cGAS? Definitely much more to follow up on TRIM5 and cGAS!

[Lorena Zuliani Alvarez, PhD @LorenaZAlvarez]

If you would like to quickly read about our key findings or the story behind the paper, don’t miss the research briefing also published in @NatureMicrobiol https://t.co/gZidKj8Hdn

[Lorena Zuliani Alvarez, PhD @LorenaZAlvarez]

This was a fantastic multidisciplinary and highly collaborative project involving an amazing team of investigators including the laboratories of David Jacques @SingMolSci, Leo C James @Jameslab9, Till Bocking, Nikos Pinotsis, and Beatrice Hahn