Cannabis use and risk of testicular germ cell tumour: a systematic review and meta-analysis - Our findings highlight cannabis use as a significant modifiable risk factor for the development of TGCT, particularly NSGCT. https://t.co/zQyQQqogQn
📊 PARPi show no clinically meaningful deterioration in health-related quality of life in mCRPC.
🔍 This meta-analysis underscores the critical need for nuanced interpretation of HRQoL data in the palliative setting.
👉🏼 https://t.co/TMBzFpOyrZ
Local radiotherapy doesn’t improve OS in mHSPC patients, but significantly prolongs time to ADT resistance.
Redefining selection criteria is key to identify those who truly benefit in the era of next-generation imaging and modern systemic therapies.
https://t.co/2mQXfN41XI
We are happy to share our recent publication,
"Effects of the NAC and Adjuvant Chemotherapy on the Prognosis of MIBC Treated With Radical Cystectomy".
Our findings showed that 3 or more NAC cycles plus AC may have limited effects on OS in MIBC patients who received RC.
What a great meeting with the Global ERBT Registry team! Great preliminary results from >1700 patients. But we need more!! Let me know if you want to join. We will provide important data regarding the management alongside ERBT!! #ERBT#EAU25#UroSoMe
I'm happy to announce that I've been accepted into the YAU Prostate Cancer Working Group! 🤩 Excited to collaborate with YAU members on future research. 🔬🚀 @GMarra_MD@dr_rajwa
🌟📢 @ASCO#GU25 |
Abstract #658
🔬 Adjuvant nivolumab (NIVO) improves DFS & OS in muscle-invasive bladder cancer (MIBC) in CheckMate 274.
@MattGalsky
📊 Key Findings (N=560, FU: 36.1 months)
✅ DFS (NIVO vs. PBO)
All MIBC: 25.6 vs. 8.5 months (HR 0.63)
With prior NAC: 19.6 vs. 8.3 months (HR 0.58)
Without prior NAC: 25.9 vs. 13.7 months (HR 0.69)
✅ OS (NIVO vs. PBO)
All MIBC: NR vs. 39.9 months (HR 0.70)
PD-L1 ≥ 1%: NR vs. 37.6 months (HR 0.48)
With prior NAC: 55.2 vs. 40.2 months (HR 0.74)
📌 Clinical Impact:
🔹 Adjuvant NIVO remains the standard of care in high-risk MIUC & MIBC.
🔹 Potential curative option post-surgery.
👥 @ASCO@OncoAlert@UroToday@gu_onc@apolo_andrea@GUOncologyNow@MattMilowsky@ScotNiglio@XinanSheng@HouedeNadine@ERPlimackMD #BladderCancer #GUcancer #CheckpointInhibitors
🧬 Preventing #ProstateCancer Progression During Active Surveillance 🧬
This systematic review/meta-analysis highlights the potential of nonsurgical interventions for prostate cancer patients on Active Surveillance:
5-alpha-reductase inhibitors (5-ARIs) ↓ risk of progression by 41%, without increasing treatment-related adverse events (TRAEs).
Mixed results for other therapies:
Effective: chlormadinone, FT inhibitors, enzalutamide, but with high TRAE rates ⚠️.
Limited benefit from lifestyle/diet interventions.
🔎 Challenges: Variability in biopsy protocols and PSA monitoring may skew findings.
Takeaway: Personalized strategies are crucial to optimize AS outcomes while minimizing risks.
Read Now > https://t.co/qQRU0yamsL @DrShariat@dr_rajwa
🧬 Preventing #ProstateCancer Progression During Active Surveillance 🧬
This systematic review/meta-analysis highlights the potential of nonsurgical interventions for prostate cancer patients on Active Surveillance:
5-alpha-reductase inhibitors (5-ARIs) ↓ risk of progression by 41%, without increasing treatment-related adverse events (TRAEs).
Mixed results for other therapies:
Effective: chlormadinone, FT inhibitors, enzalutamide, but with high TRAE rates ⚠️.
Limited benefit from lifestyle/diet interventions.
🔎 Challenges: Variability in biopsy protocols and PSA monitoring may skew findings.
Takeaway: Personalized strategies are crucial to optimize AS outcomes while minimizing risks.
Read Now > https://t.co/qQRU0yamsL @DrShariat@dr_rajwa