Mauricio Torres

Pew Latin American Fellow 🇨🇱(Chile); ER-associated degradation (ERAD), ER stress, UPR, Mitochondrial Dynamics, Mitochondria-associated ER membranes, ER-phagy.

[Journal of Clinical Investigation @jclinicalinvest]

@MedicineUVA Authors Dr. Mauricio Torres (left) and Dr. Ling Qi (right) discuss ongoing experiments in the laboratory of the Department of Molecular Physiology and Biological Physics at the University of Virginia.

[Mauricio Torres @MaurTorresg]

Happy to share our new study in @jclinicalinvest (with covers! 🥳)! We show that neuronal ERAD is essential for motor function, survival, and metabolic balance, highlighting the SEL1L–HRD1 complex and providing new insights into ENDI, a severe pediatric neurological disorder.

[Journal of Clinical Investigation @jclinicalinvest]

This issue’s Cover highlights the molecular basis of endoplasmic reticulum–associated degradation (ERAD)-related neurodevelopmental disease: https://t.co/hIjqbso9m2

Ling Qi & team @MedicineUVA reveal disruption of ERAD in neurons, through conditional deletion of the ER membrane protein SEL1L, impairs motor function and reduces survival in mice.

The cover image shows immunofluorescence staining of the ER-resident chaperone marker KDEL (magenta) and the neuronal marker MAP2 (cyan) in a coronal brain section from a neuron-specific Sel1L knockout mouse.

[Daniel Wahl @DanWahlMD]

New preprint from the Wahl lab on directly measuring metabolic pathway activity in brain cancer patients! https://t.co/WjtVwaKu27. This is led by Anjali Mittal and @AndrewScottPhD, who will be on job market soon! 1/n

[FrezzaLab @FrezzaLab]

"Organ aging signatures in the plasma proteome track health and disease"
https://t.co/ivicRcbgB1

[Mauricio Torres @MaurTorresg]

Mutation of ER-associated degradation in humans produce developmental delay and intellectual disability... Congrats to the authors!

[Journal of Cell Biology @JCellBiol]

.@SassanoLivia et al @AgostinisLab reveal that PERK promotes lipid trafficking at the ER–mitochondria contact sites thru a non-conventional, unfolded protein response-independent, mechanism https://t.co/ekkuKRdppM

In the Year in Cell Biology https://t.co/2EJQw4PsR7
#Cellbio2023

[Nature Metabolism @NatMetabolism]

Online now! Mitophagy in human health, ageing and disease https://t.co/8kflNSRyNd

[Mauricio Torres @MaurTorresg]

We had a great time talking with Dr. Lippincott-Schwartz! She is an amazing person! 😀

[Brandon Chen, PhD @BrandonTWChen]

It was amazing hosting Dr. @JLS_Lab at @umichmedicine! Thanks for presenting your exciting science with the community and sharing your wisdom with us trainees over lunch!

[Journal of Clinical Investigation @jclinicalinvest]

#Cover: ER quality-control mechanisms in the regulation of organellar organization in β cells: https://t.co/DBWRGjM348
@lingqiannarbor @scistha @MaurTorresg @RBReinertMDPhD @YouLu_UMich @apsarruda @gparlakgul @UMPhysiology
#CellBiology #Metabolism

[Neha Shrestha @scistha]

A spectacular 3D view of the beta cell Endoplasmic Reticulum made possible by the collective efforts from @MaurTorresg @ariadne_ai @gparlakgul! Check this out on https://t.co/qnZeBZITKP @jclinicalinvest #islet #diabetes #ER_literature #FIB_SEM #proteostasis

[Neha Shrestha @scistha]

Thanks @DanielJDrucker for the shoutout! So excited to share our work on the crosstalk of #ERAD, #Autophagy and #UPR pathway in beta cells. Kudos to everyone involved @lingqiannarbor @MaurTorresg @RBReinertMDPhD @YouLu_UMich @apsarruda @gparlakgul @MIP @jclinicalinvest

[Nature Portfolio @NaturePortfolio]

A @NatureBiotech paper presents a method called EEL FISH that profiles spatial transcriptomes in single cells in large, complex tissue samples. https://t.co/C8yMFdcevJ

[Nature Metabolism @NatMetabolism]

PERSPECTIVE | Recent genetic analyses of long-lived individuals are revealing variants associated with extreme human #longevity.

Vijg & Zhang (@EinsteinMed) discuss how to use this info to identify molecular targets to promote healthy #aging.

#tbt 🔙

https://t.co/6UYueyvJaa

[Mike Renne @MikeRenne]

Very exciting pre-print from John Reinhard et al. at the #ErnstLab introducing "MemPrep", an immuno-isolation based protocol for the isolation of highly purified organelle derived membranes.

https://t.co/y1LlJeY4c1

[Cell Metabolism @Cell_Metabolism]

New! Online now: OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy https://t.co/cVvBT487v1

[Anirban Maitra @Aiims1742]

Neat preprint from @FendtLab @KU_Leuven
In vivo CRISPR screen defines Slc25a37 as an organ-specific regulator of antioxidant metabolism in metastasis
https://t.co/14Xb4peSDe
CRISPR screen targeting >400 SLC transporters identifies Slc25a37 (Mfrn-1) as requirement for liver mets

[Genetic Engineering & Biotechnology News @GENbio]

#Spatialtranscriptomics on salamanders help unlock the mysteries of brain evolution and #regeneration in a first-ever stereo-seq study on axolotl. Learn more: https://t.co/ozlSCC2xff #neuroscience #traumaticbraininjury #regenerativemedicine

[Leprivier Lab "Stress responses and cancer" @AGLeprivier]

4EBP1/2 support tumorigenicity and cell survival during energetic stress by translationally regulating fatty acid synthesis https://t.co/HPVjxH9luT

[Mauricio Torres @MaurTorresg]

@PacSurfliners 20 min late already... San Diego now looks like Italy...

[Daniel J Drucker @DanielJDrucker]

Follow the leader- new single cell beta cell transcriptomes for characterization of early responsive mouse beta cells #islets @guy_rutter https://t.co/owOlDYxjPi