Pew Latin American Fellow 🇨🇱(Chile); ER-associated degradation (ERAD), ER stress, UPR, Mitochondrial Dynamics, Mitochondria-associated ER membranes, ER-phagy.
@MedicineUVA Authors Dr. Mauricio Torres (left) and Dr. Ling Qi (right) discuss ongoing experiments in the laboratory of the Department of Molecular Physiology and Biological Physics at the University of Virginia.
Happy to share our new study in @jclinicalinvest (with covers! 🥳)! We show that neuronal ERAD is essential for motor function, survival, and metabolic balance, highlighting the SEL1L–HRD1 complex and providing new insights into ENDI, a severe pediatric neurological disorder.
This issue’s Cover highlights the molecular basis of endoplasmic reticulum–associated degradation (ERAD)-related neurodevelopmental disease: https://t.co/hIjqbso9m2
Ling Qi & team @MedicineUVA reveal disruption of ERAD in neurons, through conditional deletion of the ER membrane protein SEL1L, impairs motor function and reduces survival in mice.
The cover image shows immunofluorescence staining of the ER-resident chaperone marker KDEL (magenta) and the neuronal marker MAP2 (cyan) in a coronal brain section from a neuron-specific Sel1L knockout mouse.
New preprint from the Wahl lab on directly measuring metabolic pathway activity in brain cancer patients! https://t.co/WjtVwaKu27. This is led by Anjali Mittal and @AndrewScottPhD, who will be on job market soon! 1/n
.@SassanoLivia et al @AgostinisLab reveal that PERK promotes lipid trafficking at the ER–mitochondria contact sites thru a non-conventional, unfolded protein response-independent, mechanism https://t.co/ekkuKRdppM
In the Year in Cell Biology https://t.co/2EJQw4PsR7
#Cellbio2023
It was amazing hosting Dr. @JLS_Lab at @umichmedicine! Thanks for presenting your exciting science with the community and sharing your wisdom with us trainees over lunch!
A @NatureBiotech paper presents a method called EEL FISH that profiles spatial transcriptomes in single cells in large, complex tissue samples. https://t.co/C8yMFdcevJ
PERSPECTIVE | Recent genetic analyses of long-lived individuals are revealing variants associated with extreme human #longevity.
Vijg & Zhang (@EinsteinMed) discuss how to use this info to identify molecular targets to promote healthy #aging.
#tbt 🔙
https://t.co/6UYueyvJaa
Very exciting pre-print from John Reinhard et al. at the #ErnstLab introducing "MemPrep", an immuno-isolation based protocol for the isolation of highly purified organelle derived membranes.
https://t.co/y1LlJeY4c1
Neat preprint from @FendtLab @KU_Leuven
In vivo CRISPR screen defines Slc25a37 as an organ-specific regulator of antioxidant metabolism in metastasis
https://t.co/14Xb4peSDe
CRISPR screen targeting >400 SLC transporters identifies Slc25a37 (Mfrn-1) as requirement for liver mets
Follow the leader- new single cell beta cell transcriptomes for characterization of early responsive mouse beta cells #islets@guy_rutter https://t.co/owOlDYxjPi