Excited to share our latest study published in @CellCellPress !!
We uncovered that a single oncolytic virus injection can ignite deep, persistent T cell immunity in glioblastoma, lasting months to years.
https://t.co/kulg7V0yVv
Excited to share- Building on our work defining TRMacs heterogeneity, we show that distinct chemokine+ IM subsets and recruited TAM niches shape pro- and anti-tumor immunity within to the TME, while Ag+ moDCs trafficking to LNs dampen DC-based neoAg vac
https://t.co/iYpHv6O1S4
PICI researcher Kai Wucherpfennig, MD, PhD, of @DanaFarber’s research shows a single injection of an oncolytic virus can trigger lasting T cell immunity against glioblastoma. Read more about the study and its impact here: https://t.co/6GPXJc1JZx
Now online! Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial https://t.co/SuxMIGGson
A new study led by @DanaFarber’s Dr. Kai Wucherpfennig and colleagues shows that an injection of a genetically modified virus that selectively infects and destroys cancer cells can recruit immune cells to penetrate and persist deep within brain tumors.
➡️ https://t.co/NU81vnDono
🚨Paper alert 🚨
Check out our latest paper: We identified SPP1 as a key regulator of mesenchymal cell fate. Together with GREM1, SPP1 regulates reciprocal epithelial and mesenchymal PDAC cell fate.
📚Read more about this @Nature paper below ⬇️:
https://t.co/gzD9QDaZiT
In a new Science study, researchers report that cancer cells can be reprogrammed in vivo into dendritic cells that can activate T cells and promote antitumor immunity.
Learn more ⬇️
📄: https://t.co/lIAldtvV2C
#SciencePerspective: https://t.co/BwVxhZDCxF
I haven’t posted much since Twitter is X, but I have a good reason today☺️ if you like #cancerstemcells#stemcells and #immunotherapy, this is for you! With partner in crime Phoenix Miao😎 https://t.co/f0t0Zpc4OZ
CAST enables physical alignment of spatial omics data across replicates, techs, modalities at single-cell resolution. Such accurate alignment enables spatial atlas searching, unbiased DEG identification, and reconstruction of spatial multi-omics. DM for questions and collabs!
Happy to share Novae, our new foundation model for spatial transcriptomics data 💫
Load a pre-trained model and start using Novae in two lines of code!
https://t.co/4r2kEWhYFU
https://t.co/q8NChl5Jau