They're alive!!!! ALLIIIIIIVVVEEEEEE! Newly described "zombosomes" lack a cellular 'brain' (nucleus) yet still generate energy and move about. Read about them and more of the best in @ScienceMagazine and science in this edition of #ScienceAdviser: https://t.co/A9P9lVrdOL
Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳
Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!
https://t.co/cxHl1j20CJ
So grateful for the opportunity to chat about energy, mitochondria, and health with @hubermanlab.
Would love to hear your thoughts and lived experiences if anything resonates particularly strongly.
Beautiful work on the in situ structure of ATP Synthase by @dietrich_th from the Kühlbrandt group published today in @ScienceMagazine 🔬 Discover how this important protein complex shapes the inner mitochondrial membrane! 🧪
https://t.co/xoRDR7zMgJ
The brain is full of mitochondria!
But how many, and where?
Different types of mitochondria specialize for energy transformation and other functions
In MitoBrainMap v1.0 we provide the first maps of mitochondrial content and OxPhos capacity across the human brain
#MINFLUX detects two arrangements of a protein subunit dimer by directly resolving fluorescent markers at and below FRET-range distances. MINFLUX #imaging has gone inTRA-molecular!
Learn more at
https://t.co/oRfPLYmhrw
and
https://t.co/RXbA4DrAof
@mpinat@mpi_mr_hd#Optics #
Textbook oxidative phosphorylation needs to be rewritten
with Fernando Abdulkader
https://t.co/j3LDawxKEW
Free for 50 days here: https://t.co/uEt0tOJ0Bz
I’m British.
I recently spent 10 days in the USA for business.
And discovered the ocean between us isn't water.
It's mindset.
7 uncomfortable truths about US v UK culture:
Thrilled to share the last review of the lab led by @Tabara_LC and @MayukoSegawa on the mechanisms regulating mitochondrial morphology!!! @MRC_MBU
Just out in @NatRevMCB. Thanks @lisa_heinke for the smooth editorial process!
#FluorescenceFriday#cellbiology#microtubules
1/3 Today, three views of microtubule (MT) growth dynamics by two different microscopes. First up, top and side views of growing MT plus ends at 1.2 volumes/sec in a HeLa cell in S phase for 150 time points, as seen by lattice light sheet microscopy https://t.co/vpdwTXqrdm
Delighted to share the last study of the lab led by the fantastic postdoc @Tabara_LC out in @CellCellPress !!!
We show how MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels.
@MRC_MBU@Cambridge_Uni
https://t.co/xM0vjtReOW
Congrats to Shinpei Uno on his first paper as a postdoc working with my lab and that of Richard Hartley...first of many!
Incorporating a Polyethyleneglycol Linker to Enhance the Hydrophilicity of Mitochondria‐Targeted Triphenylphosphonium Constructs https://t.co/cgzFiOru8z
Are you an #immunometabolism enthusiast? I'm excited to share our latest work out now in @Nature. This work was jointly led by @AlexHooftman, @ChristianGPeace & I, examining mitochondrial TCA cycle function in inflammatory macrophages 1/n
https://t.co/rUtyek95Q6
Delighted to share our last study @Nature. A wonderful collab with @FrezzaLab, led by @vincentZecchin1 and Vincent Paupe! We show that Fumarate drives mtDNA release in the cytosol via mitochondrial-derived vesicles (MDVs) to trigger innate immunity! https://t.co/L4FkuUm7KV
Our paper is online @NatureComms "Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes". https://t.co/kbFmNXLIQJ Congrats to all authors @dgsomucla@UCLAMBI@DOM_UCLA