Na Sun

Whitehead AI Fellow and Principal Investigator at the Whitehead Institute

[Jonathan Weissman's Lab @JswLab]

Excited to share a new preprint from the lab led by @LukeKoblan and @WilliamNColgan in which we describe our efforts to define a quantitative cell fate map of mouse embryogenesis! https://t.co/ffZdHX9ikp

[Whitehead Institute @WhiteheadInst]

Congratulations to @nasun818 on receiving the 2026 NIH Director’s Early Independence Award! The award recognizes her innovative research and the strength of the Whitehead Fellows Program, which supports recent MDs and PhDs in launching independent labs: https://t.co/VHaFkSZbQ4

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! Challenges and potential applications of AI in systems biology https://t.co/6zfeTes8Xa

[Jonathan Weissman's Lab @JswLab]

Exciting work from the lab led by @LukeKoblan @KatieEYost @sclerei @WilliamNColgan

[Na Sun @nasun818]

Excited to join @WhiteheadInst community! I’m grateful to @manoliskellis and @MITEECS for my graduate training and supporting my journey here. My lab will study the complexity of cell-cell communication and explore its broader implications across various biological scales.

[Whitehead Institute @WhiteheadInst]

Whitehead Institute appoints Na Sun as the inaugural AI Fellow within the Whitehead Fellows Program. In this role, Na will develop computational methods to decipher complex cell-cell communication in the brain. Welcome, Na! https://t.co/V20P86n2Ii

[Matheus Victor @MatBVictor]

Excited to announce that the Victor Lab is coming to NYC this Fall at the @IcahnMountSinai @SinaiBrain!

My lab will be housed at a new state-of-the art biotech hub on Manhattan's West Side! Check out the lab space and learn more from our website: https://t.co/Omj40wavfY

[Manolis Kellis @manoliskellis]

Next #ASHG23 #ASHG talk after the break: @NaSun818 on #SingleCell #eQTLs #genetic regulation of #Alzheimers in BallroomC/Level3 (10:30am)
Integrate: 427 individuals, 2.3M cells, 23 cell types and subtypes, genotypes
Results: 457k sc-eQTLs, 8.8k sc-eGenes, cell-type- / conditon- specificity, interpret AD GWAS, interpret AD DEGs
Team: @NaSun818, @ypp_lab, @Carles_Boix, @HouGroup_sysGxG, @yk_tani, #KikiGalani, #LiLunHo, with @DrLiHueiTsai and @ManolisKellis labs.
Very proud of the whole team at @MIT, @BroadInstitute, @MIT_CSAIL, @MIT_Picower, @MITEECS, @MIT_SCC
More info: https://t.co/6OnqYgExeN
Big thanks to: @NIH, @NIHAging, @CureAlzheimers

[Manolis Kellis @manoliskellis]

Don't miss @XikunHan 's #ASHG talk on #SingleCell dissection of #BipolarDisorder starting now Room207A/Level 2 (11:15am, Friday) #ASHG23 Integrate: 88 samples, 500k cells, #GWAS, single cell-#eQTLs in 2.3M cells
Results: #BD differentially expressed genes (#bdDEGs), enriched pathways, cell types, modules, #RegulatoryNetworks
Mendelian randomization #causal #driver genes and putative #therapeutic targets
Team: @XikunHan, @brad_ruzicka, @ShahinMohammadi, #PsychENCODE, #KikiGalani, #LiLunHo in @Panos_Roussos and @ManolisKellis labs. Very proud of the whole team at @MIT, @BroadInstitute, @MIT_CSAIL,@IcahnMountSinai, @MITEECS, @MIT_SCC
More info: https://t.co/NGLbA5NKIE Big thanks to: @NIH and #PsychENCODE project

[Na Sun @nasun818]

RT @manoliskellis: Don't miss @ZunpengLiu 's #ASHG talk on #SingleCell #MultiRegion #Epigenomic dissection of #Alzheimers next in Room 207A…

[Manolis Kellis @manoliskellis]

Paper 3 by @nasun818 and @MatBVictor reports 194k #microglia #scRNA transcriptomes and #scATAC epigenomes across 443 donors in #Alzheimers
1. Distinguish 12 microglial states including #inflammatory, #lipid-processing, and #homeostatic, which is most disrupted in AD
2. Discover 1542 AD-dysregulated #adDEG genes, including both state-specific and disease-stage-specific changes
3. Regulatory #circuitry of TF-enhancer-gene links and #regulators of microglial state #transitions
4. #Reprogramming of inflammatory #iPSC-derived microglia to homeostatic states by modulating our predicted TF drivers
5. AD #GWAS target genes mapping to specific microglial states, and their stage-specific changes in AD progression
Paper: https://t.co/NzEJF1wqdV
Data: https://t.co/wtIfoTj8cv
Tweetorial: https://t.co/iCbajinMZe by @MatBVictor
News: https://t.co/oLDuBBawgk
#Neuroscience #Inflammation #NeuroImmune #ROSMAP #AD430

[Cell @CellCellPress]

The new issue is out! Just in time for #WorldAlzheimersMonth, Cell features four articles that together demonstrate the genomic, epigenomic, and transcriptomic dysregulations underpinning Alzheimer's disease at single-cell resolution across cell types.

To read more click here👉https://t.co/DWf0VlDvUt

[Manolis Kellis @manoliskellis]

Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful #interdisciplinary collaboration with @DrLiHueiTsai between @MIT @MIT_Picower @MIT_CSAIL @BroadInstitute @RushUniversity
Paper 1: scRNA + vulnerability + resilience https://t.co/I7cmizyj9C
Paper 2: scATAC + GWAS + Epigenome Erosion https://t.co/bdtlu9bWDr
Paper 3: Microglia States + reprogramming https://t.co/NzEJF1wY3t
Paper 4: DNA damage + gene fusions https://t.co/hIY1tMMhLo
MIT News: https://t.co/oLDuBBb45S
Issue: https://t.co/Mup3orjhcl
News & Views: https://t.co/xQk5mepDqz

[Matheus Victor @MatBVictor]

Together, @nasun818 and I combined the power of this snRNA-seq data with in vitro modeling using iPSCs to leverage the transcriptomes of 152,459 in silico sorted microglia for functional studies on microglial state dynamics.

Interact with the data here: https://t.co/y3GtoGJweA

[Matheus Victor @MatBVictor]

What do you do when you have 2.3 million single-cell transcriptomes from 427 human brains with varying degrees of AD pathology?

You spend 3 years exploring the microglia cluster obviously!!💁🏻‍♂️

Excited to share our work out today @CellCellPress !

https://t.co/Emu0mTPUKf

[Nature Neuroscience @NatureNeuro]

Profiling single-nucleus transcriptomes in the human cerebrovasculature in six brain regions from 220 individuals with #Alzheimer's disease and 208 age-matched controls

New from @nasun818 @manoliskellis @DrLiHueiTsai and colleagues

https://t.co/8wshOHpebw

[MIT CSAIL @MIT_CSAIL]

Alzheimer’s affects 1 in 9 Americans over 65, yet its impact on brain vascular cells has been unclear.

MIT scientists characterized gene expression patterns for 22,500 brain vascular cells, revealing key insights about the disease: https://t.co/Ch5gMqxlZj

@manoliskellis

[Manolis Kellis @manoliskellis]

So excited to share our #SingleCell dissection of #Alzheimers brain #vasculature changes across 6 brain regions, out in @NatureNeuro today.
Paper: https://t.co/ACUm1a8FqL
News: https://t.co/xLv5X3vIrz
Open Access Link: https://t.co/Uy9W9FN0yc
With @DrLiHueiTsai @NaSun818 @Leyla_AAkay @MhMurdock1 @RachelEvaGordon et al

[Manolis Kellis @manoliskellis]

"The only thing more full than the auditorium tonight is @ManolisKellis poster" @LB_Barreiro intro at #BoG22... Ahem... you be the judge. Poster #135, come say hi! Full res here: https://t.co/mvWkRX0FHf #Alzheimers #SingleCell

[Manolis Kellis @manoliskellis]

Very excited for Carles Boix #ThesisDefense at 10am today on #SingleCell #Mosaicism #Brain #Alzheimers #Epigenomics Join us!
With @MITCSBPhD @MIT_CSAIL @BroadInstitute @MIT @MIT_Picower @MITEECS @DrLiHueiTsai @Peter_J_Park @YoungRickA #PReddien #ChrisBurge
Then off to @CSH #BoG22

[Manolis Kellis @manoliskellis]

Our @NeuroCellPress "Preview" Article on the role of immune genes in non-immune cells for MS is out today
https://t.co/ND4pu1WiCi
Discussing Meijer et al: https://t.co/EPvdbrRQW3
#MultipleSclerosis #Immune #MS
w/ @NaSun818 @mandy_meijer @D_eck_ard, @HowardYChang @GoCasteloBranco