Lei Hou侯磊

Assistant professor at Boston University School of Medicine

[Lei Hou侯磊 @HouGroup_sysGxG]

Exciting to see our work is out: Epigenomic regulation could reveal function of genetic variants with context information.
Very grateful to be in such a great team! @Xushen18 @manoliskellis @broadinstitute
Pls check openings in my new lab (https://t.co/hJEdleU0Km) @BUMedicine

[Manolis Kellis @manoliskellis]

Proud to share our #eGTEx multi-tissue dissection of #enhancer H3K27ac across 387 brain, muscle, heart, and lung samples from #GTEx in @NatureGenet
#eQTLs #haQTLs #SexDiffs #Epigenomics #GWAS #linking
Paper: https://t.co/5clMtduwWf (H3K27ac, today)
News: https://t.co/XImwpihTKT
m6A paper: https://t.co/CJPvNh4GOE (2021)
@MIT @MIT_CSAIL @BroadInstitute @MITEECS @MIT_SCC @harvard @harvardmed @GTExPortal

[Manolis Kellis @manoliskellis]

Next #ASHG23 #ASHG talk after the break: @NaSun818 on #SingleCell #eQTLs #genetic regulation of #Alzheimers in BallroomC/Level3 (10:30am)
Integrate: 427 individuals, 2.3M cells, 23 cell types and subtypes, genotypes
Results: 457k sc-eQTLs, 8.8k sc-eGenes, cell-type- / conditon- specificity, interpret AD GWAS, interpret AD DEGs
Team: @NaSun818, @ypp_lab, @Carles_Boix, @HouGroup_sysGxG, @yk_tani, #KikiGalani, #LiLunHo, with @DrLiHueiTsai and @ManolisKellis labs.
Very proud of the whole team at @MIT, @BroadInstitute, @MIT_CSAIL, @MIT_Picower, @MITEECS, @MIT_SCC
More info: https://t.co/6OnqYgExeN
Big thanks to: @NIH, @NIHAging, @CureAlzheimers

[Lei Hou侯磊 @HouGroup_sysGxG]

A theoretical explanation to the limited overlap between GWAS and eQTL. Instead of tracking loci by loci, maybe aggregating the genetic effect is the right way to go.

[Hakhamanesh Mostafavi @Hakha_Most]

Excited that our paper addressing the limited overlap between eQTLs and GWAS hits is now published in @NatureGenet! https://t.co/krqU7sj5Qh

[Lei Hou侯磊 @HouGroup_sysGxG]

Nice work about G + E +G xE, E Explain more variance than G ! https://t.co/JyVHeTfKZa

[Lei Hou侯磊 @HouGroup_sysGxG]

@karmelchoi @AtCMAP @ZiadaAyorech @AndreAllegrini @thaliaeley @RosaCheesman G by E!!

[Lei Hou侯磊 @HouGroup_sysGxG]

Very excited to present our work on blood epigenomics revealing immune role in bipolar disorder and subgroups in room 513A 2-2:15Pm Oct.11, Wed. #WCPG2023 @ISPGnet 🧬 . Grateful for the collaborative work with @manoliskellis @MayoClinic Tamas Ordog, Joanna Biernacka, Mark Frye!

[Lei Hou侯磊 @HouGroup_sysGxG]

@hailianghuang great name with A Big Net!

[Manolis Kellis @manoliskellis]

Congrats #KellisLab, with 4 platform presentations, 1 Epstein award winner, and 5 posters, all by #trainees at #ASHG22
Each talk/poster in the thread below 🧵
Congrats to @__ben_james__ @Xushen18 @yk_tani @boix_carles #ChristianHwa & the whole team!
Proud & grateful 🧑‍🎓👩‍🔬💻🧪🧬

[Manolis Kellis @manoliskellis]

Don't miss our #SingleCell #Epigenomics analysis of #Alzheimers #GWAS and #EpigenomicErosion in late-stage AD by @Xushen18 and @__ben_james__ at #ASHG22 starting now PetreeD/West
Abstract: https://t.co/4WwUGnIORI
Session: https://t.co/TK50K1RKJz
Slides: https://t.co/JWGySRlS5k

[Lei Hou侯磊 @HouGroup_sysGxG]

A lot of fun to read! Exciting to find out such thorough study after we discussed the same topic in Kellislab retreat! @yk_tani @Xushen18 @RTuyeras @manoliskellis

[Yang Luo @yluo86]

In contrary to the current variant-to-gene efforts, which assumes GWAS risk alleles must have some regulatory effects on gene expression (e.g. via eQTL, sQTL). Sunyaev Lab found limited evidence to support this assumption, and argues for alternative models.https://t.co/idDkKfmCHC

[Lei Hou侯磊 @HouGroup_sysGxG]

Great to know local CVS store began to encourage wearing face mask for people working there!

[Lei Hou侯磊 @HouGroup_sysGxG]

Find answers to the key questions on #COVID19: Why you don’t need to worry about the supply, when you need to wear face mask, how you could reuse the face mask, suggestion for daily activity.

[Michael Lin, MD PhD 🧬 @michaelzlin]

Here is the slidedeck on #COVID19 and the #coronavirus as PDF. Topics:
• basic facts and predictions
• how to sanitize to reduce transmission
• a review of drugs being tested
• discussion of face masks (new)
• an updated recipe for #handsanitizer
https://t.co/yMVkcOlugD

[Lei Hou侯磊 @HouGroup_sysGxG]

@LeiLi_bioinfo @MolecularCell @pottslab @superweili Congratulations!!!

[Lei Hou侯磊 @HouGroup_sysGxG]

That’s why everyone should take action to prevent the spread and save the community: keep social distance and wear face mask when going to public spaces.

[Xihong Lin @XihongLin]

Analysis results of 25,000+ lab-confirmed COVID-19 cases in Wuhan till Feb 18: epidemiological characteristics and non-pharmaceutical Intervention effects. The key results are summarized below and hope they are useful for the strategies in US and others https://t.co/ajl4MZUubi

[Lei Hou侯磊 @HouGroup_sysGxG]

Trans effects on gene expression can drive omnigenic inheritance https://t.co/Ho3feQEmP6

[Lei Hou侯磊 @HouGroup_sysGxG]

IBD risk score #ASHG18

[Lei Hou侯磊 @HouGroup_sysGxG]

With immune cells!

[Lei Hou侯磊 @HouGroup_sysGxG]

3D skin like tissue #ASHG18

[Lei Hou侯磊 @HouGroup_sysGxG]

Please stop by my poster 2236 #ASHG18 to discuss about how deconvolution of Epigenomics profiles help dissect disease mechanism in cell type specific manner.

[Lei Hou侯磊 @HouGroup_sysGxG]

Brain organoid for brain disease