Rubik Therapeutics

Next-gen cell therapies for solid tumors: tech-enabled platform discovers selective targets, suppression node modulators.

[Rubik Therapeutics @RubikTx]

@isaacbstoner @OctagonTx Great News Issac! We at Rubik share your commitment to adding diverse perspectives to the team. BTW, could you provide a warm intro to John Cena? We want to build a similar advisory, but more stripped down.

[Rubik Therapeutics @RubikTx]

@RonDePinho @JimAllisonPhD @CarolynBertozzi Go Ron!!! Maybe time to join the band?

[Jake Becraft @DrSynbio]

Biotech surge incoming. Lots of exciting science, suppressed valuations, and cash-flush buyers means things are likely to get spicy!

[Rubik Therapeutics @RubikTx]

Great to meet you at #AACR23! Exciting work!

[Actinium Pharma @ActiniumPharma]

We had a great time at #AACR23 this past week. It was a pleasure to have attendees meet our team and engage in open discussions to gain further insight into our posters highlighting Actinium’s work towards targeted radiotherapy R&D. More here: https://t.co/kdvkIt9yh7 $ATNM

[Rubik Therapeutics @RubikTx]

CAR-T in pediatric neuroblastoma: 63% ORR (17/27) including 33% CR. Wow

[Marta Barisa @MartaBarisa]

🌟Long-awaited proof-of-concept that CAR-T can eradicate solid tumours - and in immune cold paediatric tumours. Brava, Locatelli and Precision Medicine Team at Ospedale Pediatrico Bambino Gesù!

https://t.co/wMQWXiYe33

[Sergey Ovchinnikov @sokrypton]

Weekend project: Use GPT4 to generate a GUI to control conditional fold generation of RFdiffusion 😎
https://t.co/8gsscwwR3i

[Actinium Pharma @ActiniumPharma]

Actinium is focused on the development of targeted radiotherapies. Learn more about new data from our HER3 targeting radiotherapy program as well as our novel strategy utilizing Actimab-A to deplete MDSCs by visiting our abstracts ahead of #AACR23: https://t.co/xg27ybHjSq $ATNM

[Christopher Frank @chrisfrank662]

This is so awesome! Thanks so much for sharing and the awesome description in the Git🥳
It seems like we are more and more shifting from 'how to design' to 'what to design' 💪

[Jeremie Calais @CalaisJeremie]

The new PSG score is a PSMA-PET Whole-Body Tumor-to-Salivary Gland Ratio to estimate the target expression at the whole body level using the PET MIP to Predict Response to 177Lu-PSMA (PLUVICTO). Tested by 10 international experts on 237 patients. https://t.co/pfr95zMar7

[Rubik Therapeutics @RubikTx]

Been waiting for this--we have a stack of cancer-specific surface targets that need binders

[Institute for Protein Design @UWproteindesign]

Today we're making RF Diffusion, our guided diffusion model for protein design with potential applications in medicine, vaccines & advanced materials, free to use. The software has proven much faster and more capable than prior protein design tools.

https://t.co/lhkhBZNzYc

[Rubik Therapeutics @RubikTx]

@RonDePinho Looking a little "Benjamin Button" Ron! Happy Birthday!

[Rubik Therapeutics @RubikTx]

.Thanks @LabCentral @ShaziaMir71 art/science/diversity/compassion! Inspiration hung on the walls. https://t.co/QQAoECO0Ms

[Rubik Therapeutics @RubikTx]

STEAP2: 2nd priority hit from Owen Witte's '18 surfaceome discovery paper. Broad expression in normal tissue, including lung. Uniformly high in prostate cancer.

[Jacob Plieth @JacobPlieth]

SCOOP: $AZN 's first Car-T target revealed (and it's not CD19). Via @evaluatevantage -> https://t.co/DE2OFwoLZV

[Paras Sharma @paras_biotech]

Benchmarking efficacy for approved Auto CAR-Ts

From Guggenheim

[Rubik Therapeutics @RubikTx]

Another powerful dataset--Cancer Associated Fibroblast scRNAseq--just out. Thanks @simocristea !

[Simona Cristea @simocristea]

Finally, here is the link to the paper @NatureComms

https://t.co/uy9IrMyB2o

The data compiled here is a valuable resource for #cancer #genomics analyses.

It can also be quite easily further mined & visualized *interactively* via this nice portal:

https://t.co/POKBbmCvtL

[Hans-Peter Kiem @HPKiem]

Amazing and inspiring story and first clear evidence of the power of combining gene therapy with cell/immune therapy. It took a lot of courage for both Emily and her family and her doctors @BLLPHD @carlhjune @GruppSteve

[Shazia Mir @ShaziaMir71]

Breaking News! Just in - @JFruehauf awarded the @GalienFdn prize in recognition for commitment to innovation, category for #Innovation, #Accelerators, and #Equity @LabCentral @biolabs 👏 🎉🍾

[Rubik Therapeutics @RubikTx]

More + data for solid tumor cell tx @immatics IMA203 anti-PRAME TCR-T: 19-50% cORR (↑dose ↑ORR). 13/32 are melanoma pts, curious about ORR after checkpoint Rx, expect common mechanisms of resistance

[Rubik Therapeutics @RubikTx]

Nice Vans Bill!

[Mircea Ivan @OxygenIvan]

A special evening with @kaelin_lab with art Art Deco flavor.