Sergey Ryabichko

Biochemistry enthusiast

[Sam Sternberg @shsternberg]

Ever wonder if nature already 'invented' RNA-guided transcription factors like CRISPRi/a? Then look no further... we found many examples of domesticated, nuclease-dead TnpBs that use guide RNAs to repress genes! In bacteria AND phage! A wonderful team effort led by Tanner Wiegand

[Alex Holehouse @alexholehouse]

Interested in understanding how and why IDRs matter for cellular function?

@BBKrage and I took a deep dive into this question and – with excellent feedback and critiques from colleagues & our amazing editor – put together our perspective on this: https://t.co/kmaC3Zhp3R

[Victor V. Lobanenkov @boris_ctcf]

Pattern recognition in the landscape of seemingly random chimeric transcripts.

Computational and Structural Biotechnology Journal.

Published October 17, 2023.

=> https://t.co/xNgjFhfPRF

[Jason Tennessen @TennessenLab]

To all Drosophila friends interested in metabolism - I'm working on a proposal with @steven_flybase and @PerrimonLab to build new resources for the fly community. We'd like to hear your opinion on what is needed. If you are interested in taking a short survey, email or DM me.

[Feng Zhang @zhangf]

Did you know there are lots of similarities between the innate immune systems of animals/plants and the phage defense systems in bacteria? Check out our new study by the amazing trio Alex (Linyi) Gao, @maxewilkinson, and @thestrecker. Congratulations! https://t.co/jLPdHShE1t.

[Phase Transition Papers @Pha_Tran_Papers]

Intrinsically disordered regions that drive phase separation form a robustly distinct protein class https://t.co/TwJ31F9RCg

[Diego Presman @PresmanLab]

Thrilled to present our latest contribution to TFs and chromatin dynamics. Fantastic collaboration with Arpita Upadhyaya (@arpcomplex ), the Hager lab, @VillePaakinaho, @susmandrup, and many others

[Sergey Ryabichko @RyabichkoSergey]

@EkDavidA @ASleepyWanderer Nice suit! Reminded me this

[Sergey Ryabichko @RyabichkoSergey]

@EvanWeberPhD @Caroline_Bartma Midi is the top. Hail to midi!

[Marieke Oudelaar @MariekeOudelaar]

📣 Happy to share our new pre-print: The Mediator complex regulates enhancer-promoter interactions. https://t.co/brbkJIiLyo Short thread below ⬇️ (1/6)

[Hanneke Vlaming @HVlaming]

Now out in @NatureSMB: my paper on the sequence determinants of RNAPII elongation potential! I'm so happy to see it in its final form! 🤩
Find it here: https://t.co/RSHwO0B9Qd
Or view with this link, if you don't have a subscription: https://t.co/gSiVHrr5M3

[Daniel Emerson @emersond1105]

We are thrilled to share our new paper finding a functional role for the 3D genome in the localization of human replication origins (Published: https://t.co/BQtd04hHMr; Original BioRxiv: https://t.co/e59ajwkoEM) @ALCook_PhD @Olivia_Camel. 1/n

[Alina Arzamassky (Tokmakova) @AlinaArzamassky]

Extremely smart, talented, with a great sense of humor (and how to catch someone's attention) friend of mine finally did it. I expect to see more people interested in gravity! https://t.co/jJpO08wbRe

[Oded Rechavi @OdedRechavi]

"it's my turn to use the microscope"

[Sergey Ryabichko @RyabichkoSergey]

@blkkenyb @SarahTheHaider I do that too. And every time I get a thank you. Sometimes surprised thank you and a smile. Like it was something unusual.

[Nature Cell Biology @NatureCellBio]

A new study led by Yoshimura: Cell cycle-regulated phosphorylation of Ki-67 and NPM1 modulate alternating charge blocks in these proteins, which defines their propensity for #LiquidLiquidPhaseSeparation at chromatin.

PDF: https://t.co/xx9Cp9k1h3

https://t.co/H8ZkkzTIcM

[Katerina Gurova @katerinaVgurova]

TADs might be only needed for chromosome packaging during mitosis. Then this is not surprising that they are almost random during interphase. Look for factor stabilizing them during mitosis...
https://t.co/mBU7Vxm58e

[Michal Levo @Michal_Levo]

Our paper is out!
Joint work with João Raimundo (@J_Raimundo_).

Transcriptional coupling of distant genes in living embryos
@Nature

@XinyangBing, Zachary Sisco, @philippe_batut, @RyabichkoSergey, Thomas Gregor (@gregorscience) and Mike Levine

(1/6)

https://t.co/Or9laSQWTK

[Dimple Notani @DimpleNotani]

In this journal club article, I write about the discovery of enhancers by Banerji et al, 1981. Using simple but yet powerful assays, they elegantly revealed the distal nature of gene regulation ⁦@NCBS_Bangalore⁩ ⁦@EMBO_YIP⁩ ⁦⁦⁦ https://t.co/fMWe6pFthn