Asst. Professor @Texas_Heart at Baylor College of Medicine | Cardiac biology, Immunity, Genomics | Love outdoor photography, all living things | Views’re my own
Our new study with the Martin Lab uses spatial single-cell omics to dissect the cellular architecture of cardiac fibrosis in the atria. Grateful for a great collaboration and congratulations to Chang-Ru and the team! 🎉
Excited to share our latest work! Thank my mentor @jmartinlab and all the colleagues @linliucns, @RichGangLi , @Fansen2020 and collaborators @SirScienceAlot and Dr. Jun Wang and Dr. Hassan Samee.
https://t.co/7foP2SppoX
Glad that our paper is officially out @CellCellPress. BRD4 condensate functions as a pH sensor to tune inflammatory response in macrophage. https://t.co/Z6GhhU7hQD
earlier post: https://t.co/p8sim9ayaq
and could-have-been cover by my student&artist Cathleen Krabak @harvardmed
PSA: Stop calling macrophages in tissue M1 or M2. These are not states that exist in biology. The only use of M1 is a macrophage cultured ex vivo with LPS and IFNg; and for M2: IL-4/13/10. Macrophages in tissues are highly complex and diverse and do not resemble either of the aforementioned M1/M2 states. M1/M2 language causes confusion and sets the field back. Refer to your macrophages by the molecules they express and the cytokines they make.
Spatial-DMT is now published in @Nature ! For the first time, we can simultaneously map DNA methylation and RNA transcription in tissue context. Great collab with @zhouwanding lab. Big congrats to Chin @Chin72155594 , Hongxiang @HongxiangFu and team! https://t.co/9K1vtltSqG
Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matches or exceeds top-performing external models on 24 out of 26 variant evaluations, across a wide range of biological modalities.1/6
Our lab’s first discovery is out today! We identified cardiac m6A methyltransferases as a novel gene regulatory layer in heart development. More mechanisms await discovery! @Deqiang8@AccorneroLab@heewlim@ViduGargMD@SirScienceAlot https://t.co/duACwAA2Kl
Research| Jimenez et al. show that CD40 agonists can induce myocardial inflammation by activating cardiac macrophages and CD8 T cells, sensitizing the heart to secondary injury and promoting adverse remodeling.
👉https://t.co/pHbSFf5Bc0
An Australian man in his forties has become the first person in the world to leave hospital with an artificial heart made of titanium
The device could be a temporary measure for those waiting for a donor organ
https://t.co/NwfcRpm3yF