Yang-Folding

Protein Fold Annotation: 1.Sequence to folds; 2.Mutation and differentiation; 3.Misfolding; 4.Peptide and antibody design. CSO@Micropht.

[Yang-Folding @YFolding]

RoseTTAFold: Accurate protein structure prediction accessible to all https://t.co/gbszTwLWCn via @UWproteindesign

[Yang-Folding @YFolding]

@jessica_compbio @SpringerNature @NatureComms The disordered region is important.👍

[Yang-Folding @YFolding]

@sokrypton The basic task of Protein Folding is how to obtain all possible folding conformations, how to represent these folding conformations with an astronomical number and how to acquire the most possible conformation in stable state and its 3D structure.

[Yang-Folding @YFolding]

@sokrypton J. Yang, W. X. Cheng, X. F. Zhao, G. Wu, S. T. Sheng, Q. Y. Hu, H. Ge, Q. S. Qin, X. S. Jin, L. S. Zhang, P. Zhang. Comprehensive folding variations for protein folding. Proteins. 2022; 1- 22. doi:10.1002/prot.26381

[Yang-Folding @YFolding]

@sokrypton https://t.co/80ozAtsdxw

[Yang-Folding @YFolding]

Protein folding variations can be well expressed by protein structure fingerprint. See https://t.co/en3ZTyUyXI

[Yang-Folding @YFolding]

@sokrypton https://t.co/ajm3V2bIK5

[Yang-Folding @YFolding]

The nature of protein - continue folding to form multiple folding conformations

[Yang-Folding @YFolding]

@LindorffLarsen @BiophysJ @FrancPesce @BBKrage It is an interesting job for discovery of intrinsically disordered proteins. We have developed "Protein Folding Variation Matrix" (PFVM) to reveal the folding variations along sequence. https://t.co/pxDjgNvbU8 If you send me these sequences, I can generate the PFVM for you.

[Yang-Folding @YFolding]

@LindorffLarsen 2. J. Yang, W. X. Cheng, X. F. Zhao, G. Wu, S. T. Sheng, Q. Y. Hu, H. Ge, Q. S. Qin, X. S. Jin, L. S. Zhang, P. Zhang. Comprehensive folding variations for protein folding. Proteins. 2022; 1- 22. doi:10.1002/prot.26381

[Yang-Folding @YFolding]

@LindorffLarsen Also, these our two publications. 1.Jiaan Yang , Comprehensive description of protein structures using protein folding shape code. Proteins;71.3:1497-1518 (2008);

[Yang-Folding @YFolding]

@LindorffLarsen It is true that the protein folding problem has not been solved. A protein may have a mass of folding conformations under different conditions. We developed protein structure finger technology to discover the folding variations which may be a new way to solve the challenge.

[Yang-Folding @YFolding]

If you do not have a given 3D structure, according sequence, the Protein Structure Fingerprint Technology can provide PFVM, which is a matrix and has complete folding variations description.

[Yang-Folding @YFolding]

If you have a given 3D structure, the Protein Structure Fingerprint Technology can convert it into PFSC description, completely covering secondary as well as tertiary fragment.

[Yang-Folding @YFolding]

1. How to describe the complex protein folding structure?
2. How to present the flex protein folding structures?
This is a challenging project.
Protein Structure Fingerprint Technology provides a solution for this problem.

[Yang-Folding @YFolding]

Recently AlphaFold made a significant breakthrough accurately to predict 3D structures based on protein sequence. However, the protein folding problem has not been thoroughly resolved yet because protein is not a static structure.

[Yang-Folding @YFolding]

1.J. Yang, W. X. Cheng, X. F. Zhao, G. Wu, S. T. Sheng, Q. Y. Hu, H. Ge, Q. S. Qin, X. S. Jin, L. S. Zhang, P. Zhang. Comprehensive folding variations for protein folding. Proteins. 2022; 1- 22. doi:10.1002/prot.263811.

[Yang-Folding @YFolding]

A new paper of Protein Folding Fingerprint technology. "Jiaan Yang, Wen Xiang Cheng, Xiao Fei Zhao, Gang Wu, Shi Tong Sheng, Qiyue Hu, Hu Ge, Qianshan Qin, Xinshen Jin, Lianshan Zhang, Peng Zhang. Comprehensive folding variations for protein folding. Proteins. 2022; 1- 22. "