YANG HAONING

Studying intracellular lipid transport. NTUsg LKCMed, Yasunori Saheki lab.

[Ryuta Koyama @ryuta_koyama]

Lysosomal multi-omics reveals altered sphingolipid catabolism associated with lysosomal dysfunction in the aging brain: Cell Reports https://t.co/GlcCISvs1J

[Eric Topol @EricTopol]

An unexpected and potentially big finding:
A single mitochondrial protein has an outsized role, acting as a central node, coordinating our circadian clock, temperature, dietary cues, sleep/wake cycle to control brown fat metabolism @ScienceMagazine
https://t.co/jBbmaSjkaQ

[nature @Nature]

Nature research paper: A TBK1/ULK1 signalling axis couples lysosomal stress to TFEB activation

https://t.co/DBypQ0rFY0

[ShorterLab @ShorterLab]

LC3 forms functional nanoclusters on autophagosomes: https://t.co/RfODkglSrY

[LKCMedicine @NTU_LKCMedicine]

New research led by #LKCMedicine Assoc Prof Yasunori Saheki reveals how cholesterol protects cells' recycling centers during mitophagy and converts leftover fats into energy. Could offer new insights into neurodegenerative diseases! 🧬👇
https://t.co/gQILSZ0S7w

[Cell Biology J-Club @cell_club]

https://t.co/MnF8pp0Zg7

[YANG HAONING @YHaoning]

Excited to share this! Lysosomal membrane cholesterol is important for lysosomal function and lipid recycling during mitophagy. Thank you Koji, my co-first author, and all co-authors, @ysaheki for the mentorship, and Aik Yong & @Isaspore @NUSMedicine for the beautiful CLEM!

[Yasunori Saheki @ysaheki]

Our new paper revealing the link between cholesterol and the clearance and recycling of damaged mitochondria is now published in @NatureComms! Congrats to @YHaoning & Koji @NTUsg who led the study, and thanks to Aik Yong & @Isaspore @NUSMedicine for CLEM! https://t.co/RgD0DF1f4Z

[Journal of Cell Biology @JCellBiol]

An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate. From Joshua Pemberton, John E. Burke, Tamas Balla and colleagues: https://t.co/pMWwjQY6c5

📕 From our #Lipid and #Membrane collection: https://t.co/WUvZ6PLU8a

[ShorterLab @ShorterLab]

Lysosomal dysfunction drives a transcriptional and epigenetic signature found in disease-associated microglia in neurodegenerative diseases: Immunity https://t.co/GCXw7lnDlr

[Cell Reports @CellReports]

Cholesterol enhances lysosome-autophagosome fusion for better α-synuclein clearance in GBA L444P-mutated Parkinson disease https://t.co/LCIcPNsU6v

[Abdou Rachid Thiam @Rachid_Thiam]

A long-standing mystery in cholesterol biology: why is ER cholesterol sensing so switch-like rather than gradual? Our answer: cholesteryl ester phase separation in the ER, which converts small lipid changes into a cooperative transcriptional response.

https://t.co/8npJgllxNx

[LKCMedicine @NTU_LKCMedicine]

🎓 Congratulations to our #LKCMedicine PhD by Research graduates from the #NTUsgClassof2026! Discover how Dr Konstanze Tan and Dr Sara Tasnim turned curiosity into research that advances healthcare. 🔬 Read more: https://t.co/BaWsqzVDkJ

[Journal of Cell Biology @JCellBiol]

Myeong and Klyachko demonstrate that astrocytic cholesterol release modulates synaptic transmission in an activity-dependent manner to fine-tune the balance and spatial organization of different forms of synaptic exo- and endocytosis. https://t.co/4hlledgxQl

#Neuroscience

[Erik A. Rodriguez @erin_rod_phd]

🔬☀️smURFP is extremely photostable!☀️🔬
A comparison of mEGFP & smURFP photostability when fused to lifeact to image F-actin for 7 min on the Nikon SoRa.
https://t.co/HqdFRnlBmg
https://t.co/uzZgDeXO71
#FluorescenceFriday #Microscopy #SuperResolution

[Journal of Cell Biology @JCellBiol]

Lipid exchange at ER–trans-Golgi contact sites governs polarized cargo sorting. From Dávid Kovács, Bruno Antonny and colleagues: https://t.co/OBHH0JdIeA

📕 Part of “Collective Behaviors and Self-Organization in Cells”: https://t.co/Lc1mgKwmzT

[Jay Tan @JayXiaojunTan]

Today @NatureCellBio, we present a current view of lysosomal biology in aging and evaluate emerging therapeutic strategies. It has been a remarkable group effort from @AgingPitt.
Free PDF here https://t.co/k4Q88A1uKq

[Cell Biology J-Club @cell_club]

Universal cell embedding provides a foundation model for cell biology | Nature https://t.co/AneK3gYbRp

[Cell Reports @CellReports]

Cadherin regulation of endoplasmic reticulum-plasma membrane contact sites https://t.co/mJ9nAgxp6q

[Journal of Cell Biology @JCellBiol]

How does the plasma #membrane preserve its #lipid identity under stress? The Baskin and Balla labs report a homeostatic circuit linking PI4P, phosphatidylserine, RhoB, and phospholipase D-driven phosphatidic acid. https://t.co/mTsss8ZZcX

@basktastic @weillinstitute @CornellChem

[Cell Reports @CellReports]

SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism https://t.co/sfM2y2Bx31