Adrian Nasui

Software Developer | CTO | Digital Financial Services | Expanding our Software Team

[Thorsten Ball @thorstenball]

Most predictions I see are still way too conservative.

Here's mine

[Adrian Nasui @adrian_nasui]

@hkuppy This can be read either way. Brace for impact anyway, no room for a moderate, messy middle it seems.

[Adrian Nasui @adrian_nasui]

@Jason u still thinking about that Rolex though....

[Adrian Nasui @adrian_nasui]

@orrdavid life is just a process where we slowly discover and tame our cognitive dissonance, and then we die :)

[Adrian Nasui @adrian_nasui]

@RokoMijic Leaving aside engineering feasibility, What problem would floating megastructures solve? Why would humanity pursue this?

[Adrian Nasui @adrian_nasui]

@kyanyang_ Much better. But still, that's a sample size of 1.

[Adrian Nasui @adrian_nasui]

@thsottiaux Integrate as seamlessly as possible in Microsoft ecosystem. So many work is being done there. open a folder and start chatting/issuing commands. Open a resource group in azure, same. There is so much meaningful integration to be done there. Copilot today is not enough

[Adrian Nasui @adrian_nasui]

@sama you cooked, happy with it

[Adrian Nasui @adrian_nasui]

Happy to see this issue is one of Microsoft's priorities

[Satya Nadella @satyanadella]

https://t.co/xv6csf1SbV

[Bryan Johnson @bryan_johnson]

My plan to cure autoimmune gastritis

To our knowledge, no one has ever done this to try and cure an autoimmune disease.

Context: In May, I got diagnosed with autoimmune gastritis (AIG). We found it by taking a tissue biopsy of my stomach. My immune cells are confused, causing my stomach to eat itself.

AIG stops your body from absorbing nutrients like iron and B12, and can eventually lead to cancer. It likely started decades ago when I was diagnosed with hypothyroidism when 21 years old. The thyroid and stomach are closely linked in your immune system.

I feel fortunate that I've been taking such good care of my body for the past five years as my condition would otherwise be much more severe. Millions of people are affected by this disease and are undiagnosed.

Standard of care tells you that you can’t do anything about it. That’s old fashioned.

Here is how we are going to try and cure it:

Step 0: find and diagnose the disease ✅

AIG is rarely caught early because symptoms are subtle. Early warnings are low iron and B12, but when hemoglobin and hematocrit look normal, doctors routinely miss it because there are no obvious signs of anemia.

A standard colonoscopy won't find it either, because it only checks the lower digestive tract, not the stomach. It was only through a highly targeted stomach biopsy that we found it. Even biopsies can miss it if they don't sample the exact right spots. Most people with AIG go undiagnosed.

Step 1: Map my immune system ✅

Last Thursday, I had a blood draw to isolate and decode 1 million of my immune cells. Think of your immune cells as trillions of soldiers. Each carries a unique key designed to unlock and destroy a specific threat, like a virus or bacteria.

A standard blood test allows you to see how many soldiers you have, but not their keys. Sequencing one million individual immune cells allows us to read the exact pattern of the teeth on every single key.

This is important for my autoimmune gastritis (AIG) because a specific platoon of rogue soldiers has developed keys that unlock an attack on my stomach lining.

Right now, we don’t know who they are. This test will inform us of which soldiers have gone rogue and are attacking me from within.

Once we know the soldier and key, we know what therapy path to pursue to shut them down.

Step 2: Catch the rogue soldiers

I will be getting a second biopsy from my stomach because we need to collect live tissue. We are currently planning out the logistics of getting the sample from my stomach to the lab.

We need these live cells because the initial blood tests showed the antibodies, which prove that an attack is happening, but doesn’t show us the actual rogue soldier doing the damage which is a T-cell.

The live sample will allow us to match the immune system mapping we did to the live T-cells.

Step 3: Build an early warning system

To keep an eye on the disease as we work towards a therapy, we’re building an early warning system. I'll have my blood drawn every two weeks and we’ll pair that information with wearable data to look for flare ups. This is important because the attack happens without producing symptoms that I can easily feel.

Step 4: Create a “Bryan in a dish” testing model, a miniature of my immune system

At the same time, we are taking a massive sample of my immune cells and deep freezing them (cryopreservation) for two reasons:

a) we’ll create a living lab: using these cells to replicate my immune environment in a lab dish. This allows us to test experimental drugs and therapies on my actual live cells before putting them into my body.

b) it creates a back up plan for me by preserving the raw cellular material needed for targeted rejuvenation therapies in the future.

Step 5: Build precision guided therapies to end the attack

Once we know who the rogue soldiers are, we will engineer a therapy designed uniquely for them. The trick is only turning off the rogue soldiers while leaving all the other healthy ones functioning as they are.

For safety checks, we’ll do two test runs:

1) we’ll run the therapy through a computer model that has my biology to evaluate how my molecules interact.

2) We will take my actual cells that we froze in Step 4 and watch them interact for real.

If both are successful, we’ll pursue one of four therapies:

a) fix the mistake my cells are making, restoring my immune system's natural off switches

b) teach the rogue cells to tolerate my stomach instead of attacking it

c) design smart molecules that physically plug into the rogue cells and turn them off

d) build soldiers who will track down and eliminate the rogue soldiers causing the damage

[Adrian Nasui @adrian_nasui]

@Deenobrown123 "past results..."

[Adrian Nasui @adrian_nasui]

@Invesquotes @AnthropicAI Why do you think models are getting capped?

[Adrian Nasui @adrian_nasui]

@bobspaysubstack @JerryCap Nope

[Adrian Nasui @adrian_nasui]

@TheStalwart master of compression

[Adrian Nasui @adrian_nasui]

@csuwildcat I perfectly got your point and have the same feeling with health-related issues talking to chatGPT. The correlations and variants that no doctor will list patiently, you simply have them on screen and can pick every path and explore and eliminate, add nuance, work it out.

[Adrian Nasui @adrian_nasui]

@orrdavid thanks for sharing all these situations, better than any school or book imo

[Adrian Nasui @adrian_nasui]

cool thread

[Simon Sarris @simonsarris]

I think as a general pitfall of development and product design, "What should I not be doing" is almost more important.

Put another way, at any time there are a zillion choices of what to do, most of them wrong. Inherent to programming where the ease addition is extra tempting.

[Adrian Nasui @adrian_nasui]

@Invesquotes Consequently less insulin shots 🤔

[Adrian Nasui @adrian_nasui]

I'm sure this ends just fine for everyone

[All About Berlin @aboutberlin]

AI is killing All About Berlin. When you Google something, you used to get a link to my website, but now you get an AI-generated answer trained on my work. This has a devastating impact on traffic.

[Adrian Nasui @adrian_nasui]

@sama These things called diseases. Good luck, I hope you make it happen